“a decreasing trend”

In 2009, 2012 and 2018, the average number of drugs per prescription was 3.66, 3.29 and 2.77, respectively, the percentage of prescriptions including antibiotics was 65.40%, 62.31% and 46.00%, respectively, and the percentage of prescriptions including injections was 55.75%, 49.66% and 37.48%, respectively, all of which showed a decreasing trend (p<0.01).

With regard to the main effect of time, sperm quality variables including motility, viability, plasma membrane integrity and semen concentration, experienced a decreasing trend as the experiment proceeded ( P < 0.01, Table 3 ).

The incidence rates of injuries among production operation-transportation equipment personnel showed a decreasing trend (35.28 % in 2013 and 15.83 % in 2021; χ 2 = 1197.88, P < 0.01; Table 1 ). 3.2 Time of injury occurrence Over 1 year, injury occurrence rates among employees increased during summer and decreased during winter.

Among the six smaller production regions, Denver-Julesburg also shows a decreasing trend with P < 0.01, while the others show insignificant trends ( SI Appendix , Table S4 ).

A decreasing trend was observed for keratoleukoma ( P < 0.01) and an increasing trend for corneal endothelial dysfunction ( P < 0.01), regraft ( P = 0.012), corneal limbal dermoids ( P < 0.01) and congenital corneal opacity ( P < 0.01).

Between sessions one and three, all of the three techniques showed a decreasing trend of SpO 2 scores, with the exception of the pharmacological management of ADHD children (p<0.01) indicating that the uncontrollable ADHD children feel less anxious than in the other two approaches.

In SEER, among those <55 years, incidence increased at a higher rate in women (AAPC = 3.22%, p < 0.01) than men (AAPC = 1.51%, p = 0.03), with non-parallel trends ( p = 0.02), while a decreasing trend was seen in both men (AAPC = −2.16%, p < 0.01) and women (AAPC = −1.37%, p < 0.01) of the ≥55 years group.

Starting from the third week, the levels of fasting blood glucose in mice receiving EcN-GLP-1 treatment showed a decreasing trend and were notably lower compared to the M group (21.0 mmol/L versus 24.7 mmol/L, p < 0.01) ( Figure 4(b) ).

Results The standardized mortality rate of lung cancer in Handan from 2017 to 2023 showed a decreasing trend (AAPC=-7.10%, P <0.01).

The continuous submodel revealed that bullying perpetration demonstrated a decreasing trend over time (Estimate = −0.03, SE = 0.01, P < .01).

There was a decreasing trend in weight in the experimental group across the three time points (baseline to the second assessment), as compared to the control group (F = 4.29, P = .01).

With increasing SPISE tertiles, BMI, TC, TG, LDL-C, and glucose levels showed a decreasing trend, whereas HDL-C increased progressively (all P < 0.01). 3.2 Association between SPISE and left main and/or three-vessel disease Table 1 shows the cross-sectional associations of SPISE with left main and/or three-vessel disease.

For men, there was a decreasing trend in AAMR from 1999 to 2012 (APC -0.98, 95 %CI: −1.31 to −0.69) (p value = 0.010398).

However, there was a difference in the pre-PDSA cycles, with the opioid stewardship programme hospital presenting higher inpatient opioid consumption (average of 16 mg oral morphine equivalents higher; 95% CI 5 to 27; p=0.008) but a decreasing trend of −2 mg oral morphine equivalents per month (95% CI −4 to –0.6; p=0.011) compared with the control hospital.

Additionally, with each year increase in patients’ age, their costs have shown a decreasing trend ( p value = 0.011) (Table 4 ). 3.4.

A decreasing trend was shown in NHB ( P = 0.011) from 2006 to 2016.

pneumoniae , the resistance rate to imipenem and meropenem significantly increased in 2019 ( p < 0.05), while that to cefoperazone/sulbactam showed a decreasing trend during the study period ( p = 0.0110) ( Figure 4 C).

However, a decreasing trend in 100‐day mortality was observed, with improved DSS over the study period (1988–2002 compared with 2003–2017, p = 0.011), despite increased median age at PTLD diagnosis.

TRAb levels showed a decreasing trend, albeit not statistically significant (Cohen’s d = 0.71, p = 0.012) (Table 4 ).

Waist circumference showed a decreasing trend from Q1 to Q4 (102.03 ± 14.48 cm to 100.22 ± 15.99 cm; P = 0.012), while BMI remained comparable across quartiles ( P = 0.860).

Hippocampal WB analysis ( Figure 3A ) revealed significant age-dependent upregulation of cuproptosis regulators in 18M+WT mice versus young controls: FDX1 increased [One-way ANOVA: F (2, 13) = 8.739, p = 0.0039; Figures 3B,C ]; LIAS increased [One-way ANOVA: F (2, 13) = 10.95, p = 0.0016; Figures 3B,D ]; DLAT showed a decreasing trend [One-way ANOVA: F (2, 13) = 6.248, p = 0.01225; Figures 3B,E ].

Estimating the effect of ALD, NAFLD, and potential mediators on BMD As shown in Fig 2 , genetically determined ALD was significantly associated with a decreasing trend of FN-BMD at the Bonferroni corrected significance of P < 0.0125 (IVW beta = -0.0288; 95% CI: -0.0488, -0.00871; P = 0.00494).

Serological response In all enrolled patients, HBeAg showed a decreasing trend at 24 ± 2w and 48 ± 2w ( χ 2 = 8.715, p = 0.013) compared with baseline.

Results The latent variable growth model showed a decreasing trend in frailty (S = −0.197, p = 0.013) and an increasing trend in postoperative cognitive function (S = 0.124, p = 0.002) from T1 to T3 in elderly spinal surgery patients; at the initial level, frailty was negatively correlated with cognitive function ( r = −0.452, p < 0.001), and initial levels of fra

In addition, MSHQ-Bother scores showed a decreasing trend over time, reaching statistical significance at 12 months ( p = 0.013), reflecting a reduction in patients’ bother related to ejaculatory issues.