“a negative trend”

Results In primary care, there was a negative trend in fluoroquinolone item dispensing, with a 4.2% reduction in items dispensed per year (95% CI −5.2% to −3.3%; P = 6 × 10 −13 ).

Based on the observed data, a negative trend of four species lost per census (per 5 years) was observed ( figure 4 d ; average p = 2 × 10 −5 from bootstrap least-squares linear regression).

Directly (T 0 ) after the flaps were raised and 30 minutes later (T 30 ) there were statistically significant differences and a negative trend (one-way ANOVA and test for linear trend, P < 0.0001) between all ROI with lower PU in the more distal ROI in both types of flaps (Fig. 2 ).

The mean age in the total cohort was 59.69 ± 13.74 years, and the sub-cohort of younger participants (50.01 ± 13.34) in the category with the highest level of education showed a negative trend ( p = 0.0001).

Overall, in the investigated period, the results showed a negative trend (average Annual Percentage Change (AAPC) of −1.931, p < 0.0001).

uPCR demonstrated an insignificant trend with RANTES levels (ρ = -0.05, P = 0.51), whereas uPCR demonstrated a negative trend toward significance with EGF levels (ρ = -0.22, P = 0.001) (Fig. 3 B).

One study found a negative trend in calcium intake across quintiles of free sugar intake in participants aged 4–10 years ( p < 0.001) and 11–18 years ( p < 0.01) [ 19 ], and another reported a negative trend across six free sugar cut-off levels ( p < 0.001) [ 38 ].

When cluster-adjusted by hospitals, both a positive trend in atypical antipsychotics and a negative trend in typical antipsychotics remained ( p < 0.001).

Significant worsening of lipid profile was also noted with the increasing number of metabolic conditions as triglyceride (TG) levels rose (182.45 ± 109.5 vs 198.13 ± 98.8 vs 221.85 ± 102.38, P = 0.002), while high-density lipoprotein (HDL) levels showed a negative trend among MAFLD patients (41.65 ± 15.08 vs 36.05 ± 8.93 vs 32.38 ± 6.62, P < 0.001).

On the other hand, the intrasession CV had a negative trend with time ( P = 0.001; 95% Cl, –2.256 to –0.549), indicating greater intrasession repeatability of the measurements as the screws remained in place longer.

Overall, the JSD distance of Donor A x to the outcome community showed a negative trend over time (e.g. negative slopes), representing a progressive increase in the contribution of this donor community over the sampling period ( P < .001), except for A −5 with no correlation between JSD distance of Donor A −5 —outcome community and time ( P > .05).

There was also a negative trend for the song Running Away, χ 2 (1) = 11.94, p < .001.

HPIV continued to show a significant negative trend (β 3 = −0.017, p < 0.001), while hMPV also demonstrated a negative trend (β 3 = −0.016, p < 0.001).

Long‐term changes in growth rates at the population level When examining the long‐term changes in growth rates per site, the Columbretes Islands presented a negative trend in linear extension ( r 2 = 0.717, p = 0.002) and calcification ( r 2 = 0.595, p = 0.009) between 2003 and 2012, and a positive trend in density ( r 2 = 0.635, p = 0.010) and calcification ( r 2 = 0.536, p = 0.025) between 2013 and 2021.

For subclonal mutations, all our observations remained significant (anti-EGFR, β = 9.86, P = 6.23 × 10 −05 ; DNA repair, β = 11.41, P = 2.94 × 10 −06 ; length of time on cytotoxic agents, β = 0.28, P = 0.0027), and there was a negative trend for the time between samples ( β = −0.15, P = 0.0027).

Amotivation (AM) showed a negative trend, with a change in AM of − 0.3 (0.7) p = 0.003.

The linear regression between Sexual Abuse scores and metabolite concentrations showed a negative trend for choline ( p = .004), and positive trends for cystathionine ( p = .008) and homogentisic acid ( p = .022).

Among the filled spots, the proportion of positions filled by US MDs has declined from 96.69% in 2008 to 84.69% in 2022, a negative trend that was statistically significant at P = 0.005 with a beta coefficient of − 0.008.

Furthermore, a negative trend was found between sperm morphology (Q1, 6.0%; Q2–Q4, 5.0%) and semen collection time ( P = 0.007), as well as a positive trend between seminal leukocytes (Q1–Q2, 0.1 × 10 6 ml −1 ; Q3–Q4, 0.2 × 10 6 ml −1 ) and semen collection time ( P = 0.03).

However, for perseverative errors, the experimental group showed a positive oscillation, and the control group showed a negative trend ( p = 0.008, η 2 p = 0.218).

A negative trend was observed for the total sample (-1.3 pp; p = 0.009) and PT (-2.3 pp; p < 0.001), with proportions remaining reduced over time when compared to before the pandemic.

[ 19 ] TRPV4 showed a negative trend against stiffness and was significantly elevated in MCF7 spheroids grown in 2.0 kPa compared to stiffer counterparts 9.4, 13.1, and 16.8 kPa ( p < 0.01) (Figure 3A ).

Although a negative trend was observed for GAF functioning (β = −0.49, p = 0.01), it did not survive the correction.

The analgesic trajectory in women and men undergoing LOA presented a negative trend, but the pain intensity at 0–2, 2–6, 6–12, and 12–24 h in women was statistically lower than that of the OBA group ( p = 0.01, p = 0.008, p = 0.002, and p = 0.001).

For both soil types, there was a negative trend between ranked experimental PAI loss and ranked K OC (Figure S1 ), but the correlation was only statistically significant for the hydrosol ( r = − 0.592, P = 0.017).