“a numerical trend”

Although a numerical trend favored revascularization, the differences were not statistically significant in most pooled analyses, and the authors concluded that contemporary OMT may constitute a viable alternative to revascularization in selected low-risk symptomatic patients ( Rodrigues et al., 2025 ).

Although a numerical trend toward fewer ILI episodes was noted in the intranasal group, the study was not adequately powered to detect meaningful differences in comparative effectiveness.

The EBC MAIN randomized trial (467 patients) compared stepwise provisional versus systematic dual-stent strategies for true distal LM bifurcations and found no statistically significant difference in the 12-month primary endpoint (death, MI, and TLR), with a numerical trend favoring the stepwise provisional strategy.

In the YWS cohort, survival outcomes were comparable for young women with or without gBRCA PV, although a numerical trend toward better long-term outcomes was observed for gBRCA PV carriers vs noncarriers (3-year RFS = 85.5% vs 83.3%, 8-year RFS = 81.2% vs 72.1%).

The demographic shift toward older age is not merely a numerical trend, it represents a fundamental transformation in the health needs and functional capacities of societies [ 1 – 4 ].

Within this cohort, Ho-166 TARE showed a numerical trend toward improved PFS; however, no statistically significant differences in OS or PFS were observed between treatment groups in either univariable or multivariable analyses.

Intra-operative hypotensive events occurred numerically more often under SA, in a direction compatible with the known hemodynamic profile of spinal anesthesia in older adults [ 34 ], although the adjusted difference did not survive BH-FDR correction ( Table 4 ), so this remains a numerical trend. 4.2.

Conclusions Pediatric tracheostomy is a safe and effective airway intervention; however, infants weighing < 5 kg showed a numerical trend toward higher rates of cannula-related technical complications and longer hospitalizations in this cohort.

Formal subgroup analysis did not demonstrate a statistically significant difference between monotherapy and combination therapy for MNSIE, MNSIQ, or sural nerve NCV (interaction p > 0.05) but demonstrated one for peroneal nerve NCV (interaction p = 0.039), although a numerical trend towards greater benefit with combination regimens was observed.

In the IDEAL-LM study that included 818 patients undergoing LM PCI, a biodegradable-polymer everolimus-eluting stent followed by 4-month DAPT demonstrated noninferiority compared with a durable-polymer everolimus-eluting stent followed by 12 months of DAPT, although a numerical trend toward higher ischemic event rates was observed in the biodegradable polymer stent with the 4-month DAPT group [ 73 ].

While some strategies in our trial, such as mADF and lTRE, showed a numerical trend toward a slightly higher adjusted expenditure, this did not reach statistical significance.

A numerical trend toward a higher LA expansion index was observed in the RFCA group compared with the CBA group, although this difference did not reach statistical significance.

In the severe hypoalbuminemia cohort (baseline serum albumin ≤2.8 g/dL), a numerical trend toward improved survival was observed with albumin supplementation; however, this effect did not attain statistical significance(HR 0.80, 95%CI 0.41–1.58) ( Figure 3 ). 5 Discussion In the propensity score-matched cohort of SIMI patients with comparable baseline albumin levels (mean 2.8 g/dL in both groups; p = 0.142), albumin administration demonstrated no mortality benefit across all evaluated endpoints: 28-day, 60-day, and 90-day mortality, as well as in-hospital mortality.

Although a numerical trend toward higher mortality was observed in patients with elevated SII, the association did not reach statistical significance.

ECL percentages at month 3 showed a numerical trend toward higher loss in the AFS group (12.3% vs. 8.6%), but this did not reach statistical significance (P = 0.092; 95% CI − 0.62 to 8.08).

While our updated meta-analysis confirmed a definitive OS advantage, the real-world cohort demonstrated only a numerical trend.

6 A–F), although a numerical trend of decline from NC to MC followed by partial recovery in RG was observed.

Conclusion Short-lasting oxytocin inhibition through the OT-receptor antagonist atosiban did not significantly increase the incidence of migraine attacks in women with episodic migraine, although a numerical trend was observed.

1 , 36 In this study, regarding early-onset severe HDFN, we observed a numerical trend toward a 7-day delay in the gestational age at the first IUT in the combined immunotherapy group compared to the serial IUTs-only group, although this difference did not reach statistical significance.

lymph node metastasis, P = 0.305), a numerical trend towards lower expression in CIS and metastatic lesions was noted compared to the primary tumors.

While the difference did not reach statistical significance, the DSP group showed a numerical trend toward shorter procedure times.

3.7 Clinical Subtypes and Clinical Severity Correlation PSP‐RS showed a numerical trend to greater impairment in all measures, compared to the non‐Richardson syndrome variants, however, none of these differences survived FDR correction for multiple comparisons (Table S7 ).

SALT90 was achieved at 6 months by 33.3% (6/18) of patients in Group A and 11.1% (2/18) in Group B ( P = 0.10), representing a numerical trend.

Importantly, no individual TKI demonstrated clear superiority in terms of OS2, although a numerical trend toward longer PFS2 was observed with lenvatinib.

Despite the lack of overall significance, there was a numerical trend toward improved survival in the visceral obesity group, which had a median OS of 23.6 months ( n = 246) compared to 18.1 months in the non-obese group ( n = 169).