Similar to the overall participant population, no improvement in survival was observed in the nivolumab plus ipilimumab arm across key subgroups with the exception of a numerical trend toward improved PFS observed in the exploratory tumor PDL1 ≥ 50% subgroup analysis.
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“a numerical trend”
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p=0.09
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However, the subgroup analysis of STEMI patients in PLATO showed only a numerical trend toward benefit without reaching statistical significance for the primary endpoint.
A direct comparison of P1 and P2 revealed a numerical trend toward superiority of the combined treatment for Version 1 and a significant add-on effect for Version 2.
31 While neither trial reached statistical significance, both demonstrated a numerical trend toward higher mortality with colistin.
A numerical trend toward reduced efficacy was observed in patients with the highest number of emetogenic risk factors; however, this finding was based on a small sample size and was associated with wide confidence intervals, indicating substantial uncertainty.
Among people with obesity or overweight, a numerical trend of multiple obesity-related complications and higher mean (SD) CCI scores was observed in individuals with higher BMI than in those with lower BMI (CCI scores: normal BMI: 1.3 [1.8]; overweight: 1.1 [1.6]; Class 1 obesity: 1.2 [1.7]; Class 2 obesity: 1.3 [1.7]; and Class 3 obesity: 1.5 [1.8]).
Although the difference was not statistically significant, a numerical trend toward lower reinfection rates was observed in the prefabricated group.
Although standing HRV showed a numerical trend toward group differences, the absence of statistical significance precludes firm conclusions regarding autonomic function.
Although a numerical trend favoring VCDs was observed in several studies, these results suggest that discharge timing is highly context-dependent and influenced by non-clinical factors.
Nevertheless, a numerical trend towards higher +dP/dt values was evident in hearts perfused with the protein-supplemented solution ( Figure 19 ).
Overall, there was a numerical trend toward lower overlap within discordant CD twin pairs.
Patients treated with abemaciclib or with concurrent ovarian suppression showed a numerical trend toward longer survival, in line with results reported in prior studies [ 7 , 8 , 15 , 16 ].
Although the time to PR across nephron number tertiles did not reach statistical significance, a numerical trend is evident (7, 9, and 11 days, respectively).
In our study, anlotinib combined with chemotherapy was associated with a numerical trend toward longer median PFS compared with chemotherapy alone.
Prosodic contours showed a numerical trend toward more missed taps than neutral contours in both meters, though this did not survive correction for multiple comparisons; prosodic contours did, however, lead to significantly more missed taps than reverse contours even after correction.
Subgroup considerations QoH performance showed a numerical trend toward STE territory dependence, with inferior patterns appearing more prone to misclassification than anterior patterns.
[ 28 ], who reported a numerical trend in the opposite direction.
Most comparative studies evaluating two‐row versus three‐row circular staplers have reported either lower anastomotic leakage rates or a numerical trend favouring three‐row devices [ 4 , 5 , 8 , 10 ], although these findings have varied according to study design and methods of confounding adjustment.
CV Safety In the entire study population, CV safety outcomes suggested a numerical trend favoring pegmolesatide in both DD-CKD and NDD-CKD patients.
Similarly, survival analysis indicated that all three treatment regimens significantly prolonged survival compared with controls, with a numerical trend toward greater survival benefits in the HAIC plus anti-PD-L1 group relative to both systemic treatment groups (Supplementary Fig. 18K ).
A numerical trend toward higher roxithromycin resistance was observed in pregnant women (52.63%) compared to Postpartum women (32.95%), although this difference did not reach statistical significance ( P > 0.05; Table 4 ).
Since both endpoints are important for patients and clinicians, achieving both simultaneously is critical.[ 50 ] Furthermore, mirikizumab exhibited a numerical trend toward higher response rates compared to ustekinumab, particularly among patients who had previously failed biologics.[ 50 ] These findings further confirm the favorable benefit–risk profile of anti-IL-23 over anti-IL-12/23 among patients with moderate-to-severe CD, regardless of previous failure to biologics.
The sensitivity difference showed a numerical trend favoring ChatGPT-5.4 but did not reach statistical significance ( p = 0.087), and specificity was similar between the two models ( p = 0.885). 3.3.
Accordingly, a numerical trend toward higher remission/LDA rates was observed in the RTX-originator group across disease activity indices; however, these differences did not reach statistical significance and likely reflect baseline imbalances in disease severity and prior treatment exposure.
Because there was a numerical trend of higher salivary flow rate in the non-pregnant group, we compared the pregnant and non-pregnant groups adjusting for salivary flow rate by using analysis of covariance for salivary pH, and concentrations of calcium, phosphate, and sIgA.