While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).
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“a numerical trend”
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With a p -value of 0.10, the difference was not statistically significant, indicating only a numerical trend between the subgroups.
Moreover, a numerical trend of better PFS outcomes among bone-only progressors compared to others, in our cohort, underlines the potential benefit of timely diagnosis (avoiding the potential risks and comorbidities associated with a late diagnosis) and early treatment intervention.
Although a numerical trend was observed, with higher absolute and relative frequencies of mortality among patients with elevated hs-cTnI, the confidence intervals suggest the possibility of random error.
In contrast, although reductions in pork toughness and firmness were observed in these groups, these differences did not reach statistical significance, indicating only a numerical trend toward improved texture.
In phase 2, another machine learning model (random forest) appeared to show a numerical trend in improving the diagnostic performance of serum BDG and PCT alone by exploiting additional nonspecific markers, although only minimally and not in a clinically significant way [ 13 ].
In women, ever smokers and smoking amount showed a numerical trend towards lower risk of death and hospitalisation, but were only significantly associated with respiratory hospitalisation (Additional file 1: Table S2 and Table S3 ).
There was a numerical trend where women generally reported higher agreement with positive statements about MHT, such as “menopause‐associated symptoms have significantly improved,” and neutral statements about MHT, such as “treatment has improved my symptoms, but I worry about the long‐term risks,” compared with negative statements about MHT, such as “treatment has caused side effects” (Table S7 ).
Unlike prior studies of untreated psychosis, 32 we did not see a higher neuromelanin-MRI signal in those with FES compared to healthy controls, but noted a numerical trend in the relevant voxels (eFigure 2 in Supplement 1 ). 27 Alongside the lack of power, it is possible that the limited effect of FES on neuromelanin-MRI signal is due to treatment effect.
There is a numerical trend indicating that flumazenil-associated encounters required more interventions to improve ECT effects compared with nonflumazenil encounters, including lead placement change and caffeine provision.
Nonetheless, there was a numerical trend favoring the intermediate dose, suggesting potential added benefit in patients at higher risk of progression.
LAAC was associated with a numerical trend towards lower risk of hemorrhagic stroke when compared with DOACs (OR, 0.45 [95% CI, 0.17–1.22]) with no evidence of inconsistency between direct and indirect treatment comparisons ( P =0.927).
Nevertheless, a numerical trend toward symptom relief was observed, suggesting potential individual variability in response.
There was a numerical trend towards Other, Pacific Peoples and Asian patients having proportionally more proliferative (class III/IV) LN [ n = 1/1 (100%), n = 9/10 (90%), n = 16/20 (80%), respectively] compared with NZ Europeans [ n = 2/6 (33%)] ( P = 0.11).
The confidence intervals of the hazard ratios in each group exceeded 1, and all p -values were greater than 0.05, indicating no significant differences in survival rates between the subgroups (Table 2 ).Some subgroups, particularly those with clinical stage I patients (HR = 2.15), demonstrated a numerical trend; however, none achieved statistical significance.
The trial was terminated early following a futility analysis, but there was a numerical trend favoring birtamimab in the analysis of the primary composite end point of all-cause mortality and cardiovascular hospitalization in the overall population and it was hypothesized to be driven by a treatment effect in the most advanced patients (Mayo stage IV).
Although the results of this fourth experiment show a numerical trend of increased sensitivity to reward in Syrian children, the 95% Bayesian credible interval around this difference was broad and encompassed zero.
We observed a numerical trend suggesting that the incidence of OIC increased with rising opioid doses.
LANDMARK trial showed a numerical trend in favor of Myval, without reaching significance, as it was not properly powered for this comparison [ 20 ].
While underpowered for efficacy, post hoc analysis of ventilation-acquired pneumonia (VAP)s showed a numerical trend towards shorter ventilation duration and faster microbiological eradication with tosatoxumab.
Experiment 4 detected a numerical trend in predicting RSVP benefit over Full-Image search, and through the introduction of an Uncued RSVP condition that required excessive eye movements that may have contributed to performance decrements, also began investigating the interaction between eye movements/search time and RSVP.
Although we found little evidence to support that the major cannabinoids CBD and CBDA were enhanced by administrated as full spectrum products, there appears to be a numerical trend over 7 days on full spectrum CBDA absorption, therefore the “entourage effect” is not likely to be related to the major cannabinoid absorption, but rather to the minor components found in full spectrum products.
Despite a numerical trend, statistical significance was not confirmed for Lp(a) levels in relation to MADS2-CVD or MADS2-PVD scores.
Although not statistically significant, there was a numerical trend suggesting that pregnancy was associated with a history of non-participation in cervical cancer screening, despite equivalent levels of awareness.
Besides the bias towards a lower real-time CO, real-time measurements showed a numerical trend towards a better agreement with the reference standard compared to the other CMR techniques.