Barely Significant
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a numerical trend

587 sentences · 587 papers · 1,651 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

Interestingly, despite the small treated cohort, a numerical trend toward a higher digoxin serum concentration and stronger reduction in the average cluster size at day 7 was observed (secondary endpoint) (linear regression coefficient −4.65, P = 0.14; Fig. 1g ), suggesting that higher digoxin serum levels or more potent Na + /K + ATPase inhibitors could be more effective in cluster dissolution.
While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).
4 Overall survival (OS) analyses at SA1 revealed a numerical trend favoring D+CT versus P+CT (median 19.4 months [95% CI: 14.5–not reached] versus 15.9 months [95% CI: 11.6–19.3]; HR: 0.75 [95% CI: 0.53–1.05]; 55% maturity), 5 which was maintained at SA2 (DCO April 30, 2024; 20.2 mo [95% CI: 14.5–27.3] versus 15.9 mo [95% CI: 11.6–19.3]; HR: 0.74 [95% CI: 0.54–1.0