Specifically, fitting the same model that was used for predicting Anxiety to predict Depression showed an overall good fit to the data, χ 2 (22)=21.32, ns , χ 2 / df =.97, CFI=1.00, RMSEA=.00, but mediation analysis revealed only a trend level of significance for an indirect effect (a=.32, p =.074; b=−.56, p =.018; c=−.12, p =.299; c′=.06, p =.626; ab=−.18, p =.058).
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Log transformed startle magnitude was also significant in this model [F (1,61) = 35.38; p < 0.001; η 2 = 0.37] and age was at a trend level of significance [F (1,61) = 3.26; p = 0.076; η 2 = 0.051].
The group difference in DMPFC pattern discriminability was reduced to a trend level of significance, F (1, 35) = 3.33, P = 0.077, η 2 = 0.08, although the effect size based on the marginal means was medium in size, d = 0.64, with a 95% CI, [−0.04, 1.31], largely overlapping with that of the non-adjusted model, [0.18, 1.66].
Similar effects at a trend level of significance were observed when using the sum % methylation measure (group: F 1,14 = 3.627, p = 0.078, trend; time: F 2,28 = 2.22, ns, group × time interaction: F 2,28 = 0.401, ns).
However, there were more female caregivers with higher objective burden (FBIS-24) than with lower burden (61.94% vs 47.52%, p < 0.05), but this gender difference was only observed at a trend level of significance for subjective burden with the ZBI-22 (61.67% vs 51.40%, p = 0.080).
In the adherent patients ( n =40, including all three treatment groups), the drop in cortisol level (baseline value=109.9 ng/ml±63.8 and 3-month value=96.3 ng/ml±48.5) reached a trend level of significance ( t =1.79; P =0.08) compared with those who were non-adherent ( n =14; the values were respectively 99.1 ± 45.6 and 102±48.9; t =0.21; P =0.8).
IQ was at a trend level of significance ( b = .04, p = .08).
However, while performance on a measure of mental flexibility (TMT B) was significantly faster ( F = 8.32, p = 0.011), the number of errors made increased, but only at a trend level of significance ( F = 3.35, p = 0.087).
The difference in age between two groups showed a trend level of significance ( p < 0.088).
Both Non-Responders and Responders also had higher levels of IFN-γ than healthy controls, although this difference was statistically significant only for the Non-Responders ( d = 1.06, P < .001), while it reached a trend level of significance in the Responders group ( d = 0.45, P = .09).
A recent meta-analysis was unable to confirm the finding, though did show a trend level of significance ( p = 0.09) for decreased adiponectin in drug-naïve individuals with schizophrenia (Bartoli et al., 2015 ).
The oxidative glutathione disulfide (GSSG) level increased in the NAC group, however only at a trend level of significance ( p = 0.09).
When tempo cues were altered, opinion changes were not significantly associated with age in non-musicians (R = -0.49, p = 0.26) and only reached a trend level of significance in musicians (R = -0.60, p = 0.09). 3) Cochlear implant users rely more on tempo cues when implanted earlier in life and less when they have access to acoustic hearing Given that age and musical training did not explain why children using cochlear implants abnormally relied on tempo cues, additional factors related to time were explored.
Dopamine D2 receptor mRNA levels were significantly lower in bHRs than bLRs in the nucleus accumbens ( Figure 8a , P =0.04), although this reached only a trend level of significance in the caudate-putamen ( Figure 8b ; P =0.09).
Inactive lever presses did appear to be reduced during proestrus, but this only reached a trend level of significance ( t (16) = 1.783, p = 0.09; Figure 3C ).
In this model, the SOFAS had a trend level of significance as a predictor, indicating that higher SOFAS scores are seen in the presence of higher GSH levels (B = 0.43, t = 1.75, p = 0.09).
This decrease was of a similar magnitude as observed with the higher ketamine dose when compared across all epochs of analyzed activity at 5 mg/kg, however, it was only significant in epochs 5 and 6 ( t 9 = 2.28, p < 0.05; t 9 = 2.34, p < 0.05, respectively), and reached a trend level of significance in epochs 1, 2, 3, and 4 ( t 9 = 1.87, p = 0.10; t 9 = 1.98, p = 0.08; t 9 = 1.70, p = 0.13; t 9 = 1.75, p = 0.12, respectively). 5 mg/kg ketamine did not lead to a decrease in the GBO power of KA-elicited oscillations (Figure 2 ).
With regard to network composition, greater percentage of alters who know the respondent's HIV status was significantly correlated with discussion of HIV ( r = 0.60, P < 0.001), while greater percentage of HIV positive members in the network was related at a trend level of significance ( P < 0.10).
When including gender as a covariate when comparing the NOMT accuracy between DP and web controls, the difference in scores failed to reach even a trend level of significance ( F 1,297 = 2.56, p = 0.111).
While this trial was underpowered to prove a difference in akathisia between the NRX-101 and lurasidone only groups, a high effect size was seen (d = 1.1) with an increase in akathisia seen in the lurasidone group and a decrease in akathisia seen in the NRX-101 cohort at a trend level of significance (p = 0.14).
Women in the schizophrenia group had a lower score on the social domain (mean±SD 45.79±28.34 vs 60.72±28.13; P =0.056) at a trend level of significance, while they had nonsignificantly higher scores on the physical health domain (mean±SD 62.95±16.75 vs 56.96±24.90; P =0.34), psychological domain (mean±SD 59.32±21.59 vs 56.62±17.93; P =0.604), and environmental domain (mean±SD 63.21±18.62 vs 62.51±19.48; P =0.894).
In fact, performance on other cognitive domains improved less in the DCS group than in the placebo group at a trend level of significance, suggesting that DCS enhancement of learning on a practiced task may come at the cost of less improvement in unpracticed cognitive tasks, consistent with use-dependent plasticity.
Also, in unadjusted analysis supervisors were more likely to drop out at a trend level of significance, while those who had a high level of confidence at baseline were also significantly more likely to drop out.
Although the results are preliminary due to the sample size, and some only reached a trend level of significance, we will discuss them in light of the novel nature of the study.
Another study found that birthing women applying mindfulness training opted for analgesic drugs at a lower frequency than women who did not do the training, though this difference only reached a trend level of significance (Duncan et al., 2017 ).