Barely Significant
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a trend toward significance

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In the literature

Covariates included in the final Cox model were selected through a two‐step process: (i) exploratory Cox models grouping demographic, tumor‐related, and epilepsy‐related variables were first tested independently; (ii) variables showing a trend toward significance or strong clinical plausibility were retained in order to avoid overfitting while preserving control for potential confounders.
Atrophy of the caudate presented a trend toward significance. 67 In spite of variability within the literature, the most frequently observed regions of atrophy in LLD are the frontal lobe, limbic system, basal ganglia, and thalamus. 68 - 69 Within the frontal lobe, atrophy has been observed in the OFC, 68 , 70 - 74 and the anterior cingulate cortex (ACC).