“a trend toward significance”

Altogether, patients classified as responders ( n = 9) displayed a trend toward significance of increased ex vivo sensitivity (median DSS of 51.8), compared to patients achieving a poor response ( n = 4) (median DSS of 23.4) [minimal response (MR) = 1, stable disease (SD) = 1, progressive disease (PD) = 2] (Fig. 7F ).

Although these analyses revealed some differences, such as certain indicators showing a shift from significance to a trend toward significance, the main conclusion of this study—namely, the primary differences between the healthy control group and the StD subtypes—was largely maintained.

All statistics were calculated using GraphPad Prism software (ver8, GraphPad, La Jolla, CA, RRID:SCR_002798) and were defined as significant if p < 0.05; however, p value < 0.1 was also reported to demonstrate a trend toward significance.

The existence of correlations in the subiculum and CA4 and a trend toward significance in CA2/3 demonstrates that relationship between TSPO and IBA1 are not only region specific but may vary within a same region.

Of interest is the fact that we observed a trend toward significance for two SNPs in the HSD17B12 gene, namely rs10838184 and rs11037575 ( Fig 1 , Table 3 ).

There is also a significant difference between target cue and control cue potentials in the second half of the session (568–772 ms, one-tailed comparison cluster p = 0.047), confirming that the learning effect was larger for target cues than for control cues (even though the regression effect above showed only a trend toward significance).

3 A ), and a trend toward significance was also observed in intralipid-infused animals.

Adherence was inversely related to cigarette pack/years, (OR 1.55, 95% CI 1.01-2.40, p =0.048), and to CCQ overall score (OR 2.03, 95% CI 1.016-4.27, p =0.049), showing a trend toward significance with respect to gender, presence of CAD, GOLD stages, educational level, CAT score, CCQ symptoms and CCQ functional state.

Furthermore, when there was a trend toward significance, the four groups based on diet were reported for better visualization.

In multivariate analyses, being in paired relationship was the only demographic characteristic associated with unimproved work status, but univariate analyses also showed a trend toward significance that having children living at home also was associated with unimproved work status.

Further, our continuous analyses only showed a trend toward significance, likely because of a substantial positive skew on the depressive symptom variable.

score (OR = 5.872, p = 0.071) and age (OR = 1.56, p = 0.086), followed a trend toward significance.

In the present analysis, there was a significant time x group x sex interaction for TC and a trend toward significance for LDL-C, indicating that differences in TC and LDL-C levels between the IFT and CERT groups were likely driven by a varying response to the intervention, depending on sex.

If a trend toward significance is obtained, the experimental number is expanded to another 4–6 mice per group.

However, as this study was not explicitly designed to identify and test sources that could contribute to variance in DBS treatment outcomes for BE, and, moreover, post hoc analyses did reveal a trend toward significance, further studies will be needed to directly investigate whether variations in electrode placement within the NAc could underlie the observed DBS outcome variance.

Interestingly, we found a trend toward significance since the 60-day visit.

Specifically, in the analysis across the full dataset total dose (mg) was not a significant predictor for MEQ ( p = 0.109), 5D-ASC ( p = 0.736) and SIME ( p = 0.810), although a trend toward significance was apparent for the MEQ.

Post-hoc comparisons revealed a trend toward significance for a greater overall mean deviation in the old group, who performed the task in the order ecological-pointing ( M = 2.31°, SD = ±0.75), than in the order pointing-ecological ( M = 1.55°, SD = ±0.22, p = 0.073).

118 , 119 In a Phase II study in patients with predominantly negative symptoms, the addition of bitopertin 10 mg or 30 mg once daily to a stable regimen of antipsychotic therapy significantly improved the PANSS-NSFS after 8 weeks of treatment (per protocol population) with a trend toward significance in the ITT (intent-to-treat) population. 80 The SearchLyte Phase III program studying adjunctive bitopertin for the treatment of symptoms of schizophrenia is composed of six trials; three in patients with predominant negative symptoms ( NCT01192906 , 120 NCT01192880 , 121 NCT01192867 122 ) and three in patients with suboptimally controlled symptoms ( NCT01235559 , 123 NCT01235585 , 124 NCT01235520 125 ).

When treated in a univariate logistic regression model, HA‐1 disparity appeared to be correlated with an increased risk of acute GVHD ( p : 0.041, OR: 6.727) but showed only a trend toward significance in the multivariate logistic regression analysis.

[ 23 ] showed the association remained significant in the MO patients, while in the MA group, there was only a trend toward significance.

4B , right), Trappc13 only showed a trend toward significance (fig.

We also detected a trend toward significance in elevated magnitude of PD-1 + CD25 + Env-specific cT FH cells at week 41 in comparison to the pre-vaccination timepoint ( Figure 4G ), suggesting vaccine-dependent induction of Env-specific cT FH cells with a GC-T FH like phenotype.

Anxiety also showed a trend toward significance, underscoring the complex interplay of physical, mental, and socioeconomic factors on sleep.

For left targets, there was no significant difference between C.F.'s mean percentage of failed stop (M = 44%) and his controls (M = 55%, SD = 6%; t (10) = −1.755, p = 0.055), although we did find a trend toward significance.