Barely Significant
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a trend towards significance

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a trend towards significancep = 0.063–01.3× alpha
Indirect effects of the other salience/ventral attention network functional connectivity measures (i.e., segregation, intra-network functional connectivity, and right anterior insula connectivity to the right midcingulate/medial parietal cortex) on the handgrip strength-processing speed association were also observed, however, these effects only showed a trend towards significance (proportion mediated = 20.4–21.5%, p = 0.063–0.102) (Supplementary Data 7 ).
a trend towards significancep = 0.0631.3× alpha
While no significant differences were detected between No D-NEC (spheres) and D-NEC piglets (stars), there was a trend towards significance (PERMANOVA, 999 permutations; p = 0.063) and a pattern wherein piglets with D-NEC in the NEC + Lr -DM-maltose group clustered away from piglets with D-NEC in the NEC + Saline group (Fig. 4 b).
a trend towards significancep = 0.0651.3× alpha
Post hoc tests revealed that NORAD was significantly more abundant in C9ORF72 biological group as compared with NC (0.014±0.01 versus 0.0038±0.00391-fold regulation, t(99) = –2.49, p = 0.041), but stratifying according to genetic status, the comparison between NC and C9ORF72 SMC showed a trend towards significance ( p = 0.065), suggesting potentially meaningful differences ( Fig. 3 ).
a trend towards significancep = 0.0651.3× alpha
Statistical Analysis of Mutation Frequencies The statistical analysis comparing mutation frequencies between CMML-2 and the other stages (CMML-1 and AML transformation) revealed that the TET2 mutation showed a trend towards significance when compared with CMML-1 ( p = 0.065).