“an increasing trend”

Polyphenols shown by the Thyme samples revealed an increasing trend already from fresh to dried samples, with significant differences among components ( p < 0.05), except for syringic acid.

On the contrary, at age class 3–17, a drop in the number of cochlear procedures was observed between 2001 and 2004, shifting from 218 to 154 implanted devices, with an increasing trend ( p < 0.05) in the following years until reaching 236 procedures in 2023.

Although IL-6 showed a decreasing trend and IL-10 an increasing trend, these changes were not statistically significant ( p > 0.05).

It exhibited an increasing trend over the storage period, significantly increasing on day 50 compared to that on day 0 ( p < 0.05).

The interpretation of trends followed predefined statistical criteria: a decreasing trend (p-value<0.05 with a negative coefficient), an increasing trend (p-value<0.05 with a positive coefficient), and a stable trend (p-value≥0.05), according to a validated methodology ( 19 ).

2 C); however, LDTN stimulation decreased the LF/HF ratio (LF/HF ratio 1.06 ± 0.29 versus 2.11 ± 0.46, P < 0.05), the LF (nu) value showed a decreasing trend (LF 36.99 ± 10.50 versus 53.03 ± 14.46, P > 0.05) and the HF (nu) showed an increasing trend (HF 35.95 ± 11.48 versus 31.34 ± 6.13, P > 0.05).

We validated the top five upregulated genes from RNA‐seq using qPCR, each showing an increasing trend in expression after RR‐sEV treatment compared to control (Figure S9A ) with NDUFA6 showing a significant increase upon RR‐sEV treatment ( p < 0.05) This enrichment pattern, driven largely by mitochondrial and electron transport chain‐associated genes, reinforces a role for mitochondrial reprogramming.

Cytokine Concentration The vaccinated animals exhibited an increasing trend from vaccination to 5 wpv for IFN-α and IFN-γ ( p < 0.05), as well as for TNF-α and IL-12 ( p < 0.1), reaching stability from 5 wpv onwards.

Compared with the CON group, the Neu5Ac group exhibited significantly higher concentrations of formate and acetate in the jejunum, while acetate levels in the colon showed an increasing trend ( p < 0.05, Figure 6 A,B).

CVI Despite an increasing trend showed in CVI, no marked changes were observed in all regions before and after intravitreal chemotherapy (P > 0.05 for all).

Throughout the experiment, mice in the SE group and the NC group showed an increasing trend of body weight, which was consistent with that of the NC group ( p > 0.05) (see Table 1 and Figure 1b and 1 c). 3.3.

The acetic acid content showed an increasing trend during the ensiling process, with significantly higher concentrations observed on days 50 and 70 compared to day 14 ( p < 0.05).

We also observed an increasing trend of ferritin and Fe 2+ levels in the synovium with the progression of K–L grade (Fig. 8 C, * P < 0.05, ** P < 0.01, *** P < 0.001 versus K–L Grade 2; # P < 0.05, ### P < 0.001 versus K–L Grade 3).

Crude lipid content showed an increasing trend with elevated dietary Mg supplementation, with the MG6 group demonstrating significantly higher values ( p < 0.05).

The results showed that the daily intake weight of the Control rats showed an increasing trend, while the daily intake weight of rats in the other modeling groups showed a significant decrease compared to the previous day ( p < 0.05).

Compared to the CON group, TNF-α stimulation induced an increasing trend in the p-IKKα/β to IKKα/β ratio at 5 and 15 min ( P > 0.05; Figure 6 ).

Although an increasing trend in cIMT was observed in the high-risk group relative to the moderate-risk group, this difference did not reach statistical significance (P>0.05).

The nucleotide diversity and SNVs of viruses showed an increasing trend with elevation in natural soils ( P < 0.05) but not in cultivated soils ( P > 0.05) (Fig. 4g, h ).

An increasing trend of HaCS, in parallel with increasing serum anti-angiogenic factors but a decreasing trend of serum pro-angiogenic factors, was observed from baseline to onset of pre-eclampsia among the pre-eclamptic patients (p<0.05).

SOD activity in the liver also exhibited an increasing trend after fenbendazole administration, peaking around 6 days post-treatment, significantly higher than the control group ( p < 0.05).

As shown in Supplementary Figure S4 , we observed an increasing trend in the risk score in patients with pathological stage IV, and it was higher in the M1 stage compared to the M0 stage (p<0.05), suggesting that the risk score effectively reflects the severity of the disease, particularly in relation to features associated with distant metastasis.

Compared with the ACS group, the relative abundance of Firmicutes was significantly increased and that of Proteobacteria was significantly decreased in the SNDO group at d 24 and d 29 ( P < 0.05); in the SND group, the relative abundance of Firmicutes showed an increasing trend without statistical significance at d 29 ( P > 0.05), while the relative abundance of Proteobacteria was significantly decreased ( P < 0.05); the relative abundance of Firmicutes was significantly increased and that of Proteobacteria was significantly decreased at d 24 ( P < 0.05)( Fig. 5 C-D, J-K).

Next, we conducted an overexpression experiment of ALOX12B in 16HBE cells, and the qPCR and WB analysis showed that both the mRNA and protein levels of ALOX12B exhibited an increasing trend ( p < 0.05) (Figs. 5 C, D, and S 4 ); Targeted quantitative analysis of 16HBE cells overexpressing ALOX12B showed that the overexpression of ALOX12B significantly increased the level of 12R-HETE in the cells ( p < 0.05) (Fig. 5G ).

Compared with model group, the IL-1β level in Tia group and JPZDD group was significantly decreased ( p < 0.05), while the IL-6 level had a downward trend, the IL-4 and IL-10 levels had an increasing trend ( p > 0.05) ( Figure 6C–F ).

Additionally, the blood glucose concentration and low-density lipoprotein levels in the TES group exhibited an increasing trend, but they were also not different ( p > 0.05).