Barely Significant
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borderline significance

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borderline significanceP = 0.0531.1× alpha
Although the association between gallstones and recurrence risk only showed borderline significance ( P = 0.053), the higher proportion of gallstones in the recurrence group suggests that, as a chronic stimulant, gallstones might be potentially linked to the long-term progression and postoperative recurrence risk of GBC through pathophysiological mechanisms such as inducing persistent inflammation and promoting abnormal cell proliferation [ 43 – 45 ].
borderline significancep = 0.0531.1× alpha
025 in the high expression group compared to the low expression group with 95% CI [0.756, 1.390], which is not statistically significant with p = 0.873; the HR for MMP9 in renal cell carcinoma is 1.365 in the high expression group compared to the low expression group with 95% CI [0.996, 1.870] with borderline significance p = 0.053.
borderline significanceP = 0.0531.1× alpha
Various health-related factors were also significant, including tobacco use ( P = 0.039), family history of TC ( P = 0.007), medical problems related to testicles ( P = 0.005), having learned about TSE ( P = 0.002), and borderline significance for willingness to get more information on TSE ( P = 0.053).
borderline significanceP = 0.0541.1× alpha
Additionally, univariate analysis revealed that a higher lymphocyte count (≥1.5×10 9 /L) showed borderline significance for improved DFS ( P = 0.054), while a lower monocyte count (<0.4×10 9 /L) was associated with a significantly better DFS ( P = 0.010).
borderline significancep = 0.0541.1× alpha
The complication rate for patients operated on for infectious indications (6.2%) was significantly higher than for obstructive indications (1.4%) ( p < 0.001) (Tables 2 , 3 ). In multivariate analysis, the most significant independent risk factors for complications were: Age at the time of surgery (OR 1.044, p = 0.004) Sex (male predominance, OR 2.354, p = 0.04) Indication for surgery (infectious predominance, OR 2.52, p = 0.054, borderline significance) The analysis revealed an additional risk of 4.4% for complications with each year of age.
borderline significanceP = .0541.1× alpha
Tertile-based analysis revealed a nonlinear dose–response pattern: compared with T1 (2.0–19.8 mmol/L), T3 (24.0–51.0 mmol/L) exhibited persistent protective effects in logistic regression (Model 3 OR: 0.77, 95% CI: 0.64–0.93, P = .006) and Cox (Model 3 HR: 0.78, 95% CI: 0.66–0.92, P = .003) models, while T2 (20.0–23.9 mmol/L) exhibited borderline significance in logistic regression (OR: 0.85, P = .054) but remained protective in time-to-event analysis (HR: 0.79, P = .002; Table 4 ). 4.