“borderline significant”

Additionally, the statistical thresholds in whole-brain analyses may detect weak or borderline significant effects, whereas ROI-wise GLMs, which assume uniform behavior across the entire region, may miss the same effects if the signal is weak or inconsistent across the ROI.

Although the cosine function best captured seasonality in the univariate model, the sine function remained the only predictor of seasonality in the multivariate model, albeit only borderline significant.

In six cohorts with estimates of lymphatic tissue dose, borderline significant increased risks ( p-trend =0.02-0.07) were observed for NHL+CLL, NHL, CLL.

In turn, one standard deviation increase in tree ring growth has a borderline significant, negative impact on GDP per capita that persists over the first decade, peaks at 0.5% after 11 years and fades away soon afterwards.

Moreover, we also found the associations of the rhythm domain with the primary motor (β = 0.109, FDR = 0.047) and sensorimotor (β = 0.103, FDR = 0.047) cortex were borderline significant after full adjustment (Table S4 ).

In addition, other LPCs, such as LPC(17:1) ( P = .0058), LPC(18:1e) ( P = .0055), and LPC(20:5) ( P = .0087), showed borderline significant association.

Due to the relatively small sample size, the CI for borderline significant independent variables was inspected (ie, inspection of the lower limit CI in relation to the size of effect estimate) for indications of incorrect omission from final models. 36 All final models were deemed to have sufficient CI coverage, based on the events-per-variable ratio. 36 Using methods described by Cleves et al , 37 final models showed no violations of underlying assumptions of proportional hazards (eg, tests based on reestimation, interaction of analysis time with the independent variables and graphically through Schoenfeld residuals) and showed appropriate model fit.

Both of these models were considered among tertiles of plasma marker concentrations and in both unadjusted and adjusted analyses, and those significant and borderline significant associations between soluble inflammatory markers (CD14, CD163, hs-CRP, TNFR-I, TNFR-II, IP-10, CCL2, CCL5, and CX3CL1) and peri-coronary inflammation suggest targets for further investigation in mechanistic studies.

We also performed qRT-PCR on an additional 135 genes of interest that showed borderline significant differential expression.

non-smokers were 0.56 (0.42–0.75) and 0.56 (0.40–0.79), respectively, with a P -value for heterogeneity significant or borderline significant.

Catecholamines and thyroid parameters were normal and did not change from initial hospitalization to the 3-months control visit (although noradrenalin was borderline significant).

Our finding that leptin was associated with a decreased risk of all-cause dementia, although borderline significant, and AD was consistent with a previous longitudinal study and with its implicated beneficial role in brain functioning ( 10 ).

Although the three NOSES groups showed similar T staging distribution (P>0.05), a borderline significant difference was found across all four groups.

All these genes ( AREG, GREB1, TFF1 and TFF3 ) were up-regulated in ER+ carcinomas compared to ER- carcinomas ( AREG was only borderline significant) (Additional file 3 ).

Furthermore, the timing of the study was borderline significant and explained 11% of heterogeneity.

In the analysis in which we stratified the association between changes in cardiac structure/function and vitamin D by baseline LVH status and fish oil randomization, there were 2 statistically borderline significant associations, and neither favored vitamin D supplementation (Table S4 ).

The effects of high temperatures on mortality affected the vulnerable population over 65 compared to those under 65, although the difference was borderline significant.

Males and ever smokers had a borderline significant increase in HCC risk ( P value, 0.091 and 0.066, respectively).

Visually, most funnel plots appeared relatively symmetrical, although some outcomes (e.g., VO 2 max and waistline) yielded borderline significant p-values (both 0.010) in Egger’s test, suggesting a potential small-study effect.

The HRs were approximately the same, but hs-CRP changed to be borderline significant (aHR 1.34 [95% CI 1.04–1.71]), while TIMP-1 changed to borderline nonsignificant (aHR 1.26 [95% CI 0.94–1.69]) ( Supplementary Table 6 ).

However, the difference between Q and its df (18.39 – 10 = 8.39) for IVW and (Q’, 16.99 – 9 = 7.99) for MR Egger are small, indicating (alongside the borderline significant p -value) that the heterogeneity was not substantial.

Nonetheless, sensitivity analyses revealed that the independent relationship between proteinuric severity and BI scores exists even among those without hypertension or DM, and the relationship was borderline significant or those without CKD ( Table 5 ).

However, in the prucalopride group, there was a borderline significant difference between the groups in terms of positive affect at the post-intervention research visit, with higher scores in the prucalopride group compared with the placebo group [PANAS-P mean (SD): placebo 29.1 (6.98), prucalopride 33.2 (7.35), t (46.6) = −1.99, p = 0.05, Cohen’s d = −0.57 (−1.14, 0.00)], which was not wholly explained by PANAS scores at baseline (see Table 1 )].

6C ) showed borderline significant difference while CCL4 (Fig. 6D ) was significantly higher in BTK-High cluster.

Average tool use skill was also genetically associated with truncus and FAC1 and borderline significant with the genu.