“did not reach statistical significance”

In this standalone setting, the VMN, with its higher aerosol output rate and superior aerosol characteristics (lower MMAD and higher FPF), as also reported in the literature [ 27 , 28 , 29 ], showed a trend toward slightly higher drug delivery compared to the JN, although this difference did not reach statistical significance ( p = 0.309).

Casein content displayed a decreasing trend from Enhanced to Not Classified farms; however, this pattern did not reach statistical significance after correction for multiple testing.

Baseline LDH levels showed a numerical trend toward higher values in dogs that subsequently developed PD (median 748 U/L; range: 612–921 U/L) compared to those achieving CR (median 612 U/L; range: 398–846 U/L), although this difference did not reach statistical significance ( p = 0.286, Kruskal–Wallis test), likely due to limited sample size. 3.7.

Xylazine dose showed a trend toward reducing surgical interference (Estimate = −1.53; 95% CI: −3.28 to 0.15), but this did not reach statistical significance ( Table 5 ).

Urine GPX4 showed an increasing trend in the later stages of CKD, although the difference did not reach statistical significance.

Although the association between mucositis severity and cGvHD risk did not reach statistical significance in our patients, there was a clear trend, consistent with the finding of moderate-to-severe oral mucositis as an independent risk factor for cGvHD in a recent study with a larger sample size (230 patients). 20 Whether plaque S. sanguinis is citrullinated in these patients and can be found in the circulation or cGvHD target organs is worthy of further research.

Additionally, we analyzed the Gene Expression Omnibus (GEO) database ( GSE83452 ) and found that the expression of SELE was significantly elevated in the livers of MASH patients, while ICAM-1 expression showed an increasing trend but did not reach statistical significance (Fig.

In contrast, attendance at health centers showed a trend toward reduced odds (aOR = 0.26, 95% CI 0.05–1.23), although this did not reach statistical significance ( p = 0.09).

The MBOA group showed a trend of longer-term improvement in loneliness at T3, but the modest magnitude of change did not reach statistical significance compared with the SCC group, in which no such trend was observed.

30 , 31 Iron deficiency demonstrated a significant association with oral cancer (RR = 1.067, 95% CI: 1.002-1.136, P = .042), while its association with periodontitis showed a positive trend but did not reach statistical significance (RR = 1.026, 95% CI: 0.996-1.057).

The expression levels of inflammatory factors (IL‐6, IL‐1 β , and TNF‐ α ) in the hippocampus of low BBR dose mice indicated a decreasing trend compared to the LPS group; however, this difference did not reach statistical significance (Figure 5 E–G).

RT-qPCR results demonstrated that the mRNA expression levels of ACACA and ACLY in the Sj group were significantly higher than those in normal liver tissues ( P < 0.05), and the mRNA expression of all three genes showed a trend of “Sj group > HBV group > normal control group” (though the intergroup differences did not reach statistical significance).

ERG recordings also showed a trend toward reduced b-wave amplitudes in the 0.01 DA test, although this difference did not reach statistical significance ( Figs. 4 C, 4 D, P = 0.61).

Other features showed a trend toward the predicted direction but did not reach statistical significance using a conservative bootstrapping technique.

Notably, although the pooled analysis did not reach statistical significance, the meta-analysis showed a numerical trend toward increased risk (OR 1.37) accompanied by very high between-study heterogeneity (I2 = 87.2%).

In contrast, in patient aged ≥ 80 years, the OS benefit associated with maximal resection showed a favorable trend but did not reach statistical significance ( p = 0.11, Fig. 3 C).

The multifactor ANOVA further supported these findings, demonstrating that tumor size ( p < 0.001) and SI motion ( p < 0.001) have a highly significant influence on registration quality, whereas the respiratory cycle and AP/LR motions did not reach statistical significance ( p > 0.05).

Supernatants from microglia exposed to EVs loaded with let-7e or miR-548b-3p showed an increasing trend of TNF release, however, those TNF release levels did not reach statistical significance.

Hypertension showed a trend toward association but did not reach statistical significance.

Weekly intercourse frequency showed a trend toward being lower in the SPE group but did not reach statistical significance ( P = 0.062).

For changes in total palatal volume (ΔTV), sagittal displacement of the maxillary central incisors relative to the vertical reference line (ΔU1⊥VRL) showed a positive trend toward volumetric increase, although this association did not reach statistical significance ( p = 0.068).

GluN2B expression also showed a trend toward a decrease; however, this change did not reach statistical significance (Fig. 7a, c ).

The proportion of helper T cells (CD3 + CD4 + ) showed a decreasing trend but did not reach statistical significance (Fig. 5 C and G).

Functional status Within-group analysis in the TECAR group showed a trend toward improved lower extremity functional scores over time, although this change did not reach statistical significance (p=0.058).

Concurrently, the trabecular bone volume over the tissue volume (BV/TV) in the femurs showed a decreasing trend up to 24 h after the sRANKL injection, although this change did not reach statistical significance (Fig. 1b ).