Barely Significant
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extremely significant

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extremely significantP < 0.0010.0× alphaqualified
The best effective group was a combination of curcumin 50 mg/kg with piperine 20 mg/kg which showed extremely significant ( P < 0.001) decrease and increase in ECG and serum biomarker level, respectively, and moderate significant ( P < 0.01) decrease in lipid profile, antioxidant levels, and histopathological score, compared to curcumin alone-treated group.
highly significantP < 0.0010.0× alphaqualifiedgold
P < 0.05 were considered statistically significant (*), P < 0.01 were considered highly significant ( ⁎⁎ ) and P < 0.001 were considered extremely significant ( ⁎⁎⁎ ), respectively. 3 Results and discussion 3.1 Synthesis and characterization of B-TPP As depicted in Scheme 1 , carbodiimide chemistry was used to covalently conjugate TPP to Brij 98.
extremely significantP value < 0.0010.0× alphaqualified
10 The overall meta-analysis study was extremely significant with a P value < 0.001 with a pooled estimate of 7.987 and CI (5.334, 10.639), confirming the significance of the results and the presence of the real effect of the use of the particulate systems on the pharmacodynamic responses of the investigated drugs, as revealed by AUEC.