“highly significant”

The combined analysis of all four studies including a total of n = 1,910 cases and n = 3,630 controls showed highly significant evidence for association between rs1739843 and idiopathic DCM (p = 5.28×10 −13 , OR = 0.72 [95% CI 0.65–0.78]).

The age x genotype within sex interaction was also highly significant ( p = 5·5 × 10 −13 ).

The comparison of the fixed effects of the rs181206[G] allele resulted in highly significant estimates: β ^ m u t a n t = -1.11 ( P = 5.52x10 -13 ) for IRF1 and β ^ m u t a n t = -1.28 ( P = 4.86x10 -10 ) for STAT1.

A pooled dataset, consisting of 19 studies with long-term clinical follow-up, also demonstrated a highly significant (p= 5.80 × 10 −13 ) inverse correlation between DICER and hypoxia.

Each of these additive effects were highly significant (F statistic > 60, d.f. numerator , = 1, d.f. residuals = 175, p < 6 x 10 −13 ; Fig 4 ; Table 1 ).

The most prominent peak was detected on chromosome 19 at position 45,281,163 bp, with a highly significant P-value of 6.03 × 10 –1 3 (-log 10 (P) = 12.22).

The coding region (CDS) of these genes also contained a highly significant enrichment for hexamer seed matches (p = 6.1E-13).

The overlap between early and late was highly significant ( p = 6.4e-13, Fisher test).

For example, we found highly significant functional enrichment among the interacting partners for the GO terms “cytoskeleton” (P value = 6.6 × 10 −13 ), “TFIID complex” (P value = 1 × 10 −14 ), and “proteasome” (P value = 6.6 × 10 −13 ) ( Haarer et al. 2011 ).

This difference in proportion Metazoan is highly significant (P = 6.91×10 −13 , Fisher's Exact Test); induced genes are also much more likely to be wasp-specific (31.3% induced, 16.3% other genes, Fisher's Exact Test P = 8.85×10 −7 ).

The ANOVA results revealed highly significant differences among treatments for both Tret1 ( p -value = 7.78 × 10− 13 ) and Tret1-like ( p -value = 1.32 × 10− 13 ), both far below 0.0001 significance p- value threshold, indicating that exposure to insecticides and acetone markedly affected gene expression.

Sylamer analysis using all 7-nt motifs complementary to seed regions of mouse miRNAs revealed a highly significant (P < 8 × 10 −13 ; Bonferroni corrected < 7 × 10 −10 ) enrichment for the 7-nt seed match of miR-451 (AACGGTT) in the 3′ UTRs of genes in a cohort of 588 genes, most of which were up-regulated in miR144/451 −/− erythroid precursors ( Fig. 4 B ).

For both models and both states, there are highly significant differences in importance values across the three classes of phenotypic impact (RF MN: P = 8.15 × 10 − 13 ; RF TX: P = 2.20 × 10 − 16 ; FFNN MN: P = 2.20 × 10 − 16 ; FFNN TX: P = 2.20 × 10 − 16 ).

The proportions were 0.962 ± 0.040 for AAV1-labeled neurons and 0.492 ± 0.066 for FluoroGold-labeled neurons, indicating a highly significant difference ( p = 8.6 × 10 –13 , Wilcoxon rank-sum test).

However, the death rate was 34% in co-infected ( n = 170) compared to non-co-infected patients ( n = 128), indicating a highly significant value ( p -value = 0.00000000000088).

We observed that the tumor types with highly significant KDM7A-DT gain and amplification were highly aggressive, including hepatocellular carcinoma ( p = 8.8E-13), pilocytic astrocytoma ( p = 3.43E-10), melanoma ( p = 5.21E-10), prostate adenocarcinoma ( p = 5.16E-08), medulloblastoma ( p = 4.20E-07), and colorectal carcinoma ( p = 6.14E-04).

Conversely, the variety has a very highly significant effect ( p = 9 × 10 −13 ) on the intercepts of these relationships.

The genotypes (RIL and accession) had a highly significant effect in both populations ( P -values ≤ 9.92e−13).

In this ANCOVA the effect of phenotype is not significant ( P = 0.09) while expression level is highly significant (P<10 −12 ).

The TPT main effect was highly significant regardless of the data set used (full data set: F 10,370 = 37.6, p<1×10 −12 ; limited data set: F 10,370 = 30.7, p<1×10 −12 ), clearly indicating the significance of the online compensatory adjustments of F1 in response to the AF perturbations when the data were collapsed across the two groups of subjects.

Furthermore, analyzing the sample similarity based on these cluster frequencies resulted in highly significant grouping of samples with the same diagnosis ( P < 10 −12 ; Fig. 3E ).

The direct comparison of all 1-kb regions reveals that this higher B in the X chromosome relative to autosomes is highly significant (Mann-Whitney U Test, P <1×10 −12 for complete and trimmed chromosomes), with all BGS models generating the same trend and level of significance.

When we applied Fisher's exact test to gene sets identified by the different approaches ( Supplemental Figure S3A–C ), we always found highly significant overlap (more genes in common than expected by chance) between the SB Driver Analysis and GKC analysis methods ( P < 10 −12 ).

Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).

We also found a highly significant main effect of cluster ( F (6, 247.48) = 237.58, p < 10 −12 ), showing that different neural clusters had distinctive baseline activity levels.