“highly significant”

Pearson correlations with PC[1] scores were highly significant ( P < 10 −12 ) for height ( R , 0.65), yield ( R , 0.56) and growth rate ( R , 0.62).

An unanticipated outcome was the finding of a highly significant (p < 1 × 10 −12 ) relationship with up- and down-regulated genes encoding effectors of the DNA damage response, including BRCA1 , CHK2 and RAD51 , among many others (Supplemental Fig.

Notably, a highly significant enrichment of RGAC motifs at NKAP-binding footprints (CIMS or CITS along with a 5-nucleotide flanking sequence) was identified by iCLIP-sequencing ( P < 10 −12 , Wilcoxon rank-sum test, Fig. 5g ), suggesting that NKAP preferentially binds the m 6 A core motif RGAC.

The DEG group with stress-induced downregulation (blue) demonstrates a highly significant ( p < 10–12) positive correlation between PC1 and PC2.

To test this more formally, we assessed baseline pupil size in our a priori baseline time window −1 to 0 s and found a highly significant difference in pupil size preceding certain vs. uncertain choices ( β C > 0 , t = 6.9 , p ~ 10 − 12 , CI = 0.03 , 0.05 ) (Figure 2A , inset bar plots).

Of the 119 genes that were both represented in the MCF-7 dataset and increased in EGFR -mutant NSCLC cells, 44 (31%) were increased with P <0.05 in EGFR -transfected MCF-7 cells, which represented a highly significant overlap ( P <1E–12, one-sided Fisher's exact test, Fig. 2 E ).

The TPT main effect was highly significant regardless of the data set used (full data set: F 10,370 = 37.6, p<1×10 −12 ; limited data set: F 10,370 = 30.7, p<1×10 −12 ), clearly indicating the significance of the online compensatory adjustments of F1 in response to the AF perturbations when the data were collapsed across the two groups of subjects.

The overrepresentation of mutations in subtelomeric regions is highly significant in O. tauri (10 vs. 94 mutations in subtelomeric versus nonsubtelomeric regions, Fisher exact test, P -value <10 −12 ), B. prasinos (8 vs. 24 mutations, Fisher exact test, P -value <10 −12 ) and M. pusilla (4 vs. 81 mutations, Fisher exact test, P -value <10 −4 ).

The MUA response to visual stimuli (median 0.1 SD above baseline) was not significantly different from 0 (sign-rank test p = 0.6), while the responses to auditory (median 2.7 SD) and audio–visual stimuli (median 1.6 SD) were highly significant (sign-rank tests, p < 10 −12 and p < 10 −9 ).

Indeed, we found the correlation between rankings of two reported lists was positive (Spearman’s correlation coefficient ρ = 0.68) and highly significant (p value < 10 −12 ).

In our HSA14 simulations, the presence of heterochromatin slightly reduces the absolute value of the correlation, which however remains highly significant (Spearman correlation r ≃ −0.83, p < 10 −12 ).

neurons 21 to 100) highly significant (t-test; p < 10 −12 ) ( Fig 7C , right).

We found a highly significant ( p < 10 −12 ) positive ( R 2 > 0.51) correlation between levels of expression of 2071 transcripts whose expression was affected by both stimuli.

9B ) shows functions related to “Cellular Movement, Hematological System Development and Function, Immune cell trafficking and cell-mediated immune response”, with a highly significant score of 12 (p = 10 −12 ) (Fig. 9 ).

The general lack of diagnostic specificity is also apparent in the Spearman's rank correlations (Table 4 and Supporting Information Tables 2 and 3), as for each pair of diagnoses, correlation coefficients across regions ranged between 0.42 and 0.82 and were highly significant (0.001 < P < 10 −12 ).

The difference in substitution scores between core and surface region is highly significant for both SVD and CSM ( P <1.0 −12 ) and significant for SVP ( P <1.0 −4 ), whereas it is not significant for SAP ( P <0.78).

The Chi-Square test showed a highly significant correlation of all tests with the latent class (p < 10 12 or lower).

Results The differences in the distribution of SE between the wake and N2, and wake and N3 were highly significant ( p < 10 − 12 for both comparisons), whereas the difference between the wake and REM states was not ( p = 0.12 ).

The direct comparison of all 1-kb regions reveals that this higher B in the X chromosome relative to autosomes is highly significant (Mann-Whitney U Test, P <1×10 −12 for complete and trimmed chromosomes), with all BGS models generating the same trend and level of significance.

A linear regression of the first principal component (PC1, explaining 20% of the functional variance) and the relative abundance of the Bacteroidetes showed a highly significant correlation (R 2 =0.96, p<10 −12 ; Fig. 2B ).

Furthermore, analyzing the sample similarity based on these cluster frequencies resulted in highly significant grouping of samples with the same diagnosis ( P < 10 −12 ; Fig. 3E ).

CC15 exhibited highly significant associations with both ant(4’)-Ia and lnu(A) ( P = 1.01E-12, OR = 583.8 for both).

A chi‐squared test confirmed a highly significant association between vector construct and co‐transformation frequency ( χ 2 (3) = 58.87, P = 1.03 × 10 −12 ).

A statistical analysis using the chi-square test of independence revealed a highly significant difference between the groups (χ 2 ≈ 43.6; P < 1.04 × 10 –12 ), confirming that a full stomach exerts a protective effect on the pars oesophagea and significantly reduces the risk of ulcerations.

Indeed, of the 1,734 KHSRP targets identified in Winzen et al, 43 245, or 14%, overlapped with the 1,589 ischemia-stabilized mRNAs, an overlap that was highly significant via normal approximation of exact hypergeometric probability (Representation factor: 1.5, p < 1.064e −12 ).