“highly significant”

For instance, the highly significant "neurological process" (p = 4.45 × 10 -12 ) and their descendants (see Figure 2 ) are probably related to the undifferentiation process o neuronal cells.

A highly significant survival deficit was observed for pooled treatment ( SFB , n = 6 × 18) versus vehicle (DMSO, n = 2 × 18) of positive control groups by Fisher’s exact test ( p = 4.5 –12 ).

Of these, highly significant replications were marked for rs3812316, near gene MLXIPL ( P = 4.6 × 10 −12 ) and rs1150442 near gene EYA2 ( P = 1.4 × 10 −6 ) in the recent study of Pulit et al. 36 4.

This enrichment was highly significant (p = 4.8 × 10 −12 for mESC overlap; p = 2.3 × 10 −13 for hESC overlap) and constitutes a robust simplification of the Oct4 targets.

The difference remained highly significant ( P = 4.8 × 10 −12 ).

The BS platform was substantially more likely than ChatGPT-4o to correctly identify metastatic regions, and McNemar's test showed highly significant imbalances in discordant pairs, with p values approaching zero in lesion-level analyses (exact McNemar p = .0000000000048).

Only the standard ANOVA across the four-state system was highly significant ( p = 4.97 × 10 −12 , η 2 = 0.14) with the phylogenetic ANOVA and pairwise t -tests producing non-significant results ( figure 4 ).

The differences between the ‘early’ and ‘late’ are highly significant ( t ‐tests, p ‐value < 5e‐12 to p ‐value < 5e‐65).

Using the type of feeding behaviour (single vs multiple hosts) as a binary response variable, the final model selected by maximum likelihood included a highly significant effect of type of host (LRT: χ 2 = 52.0, df = 2, p = 5.09e-12) and a significant effect of site (LRT: χ 2 = 13.2, df = 5, p = 0.001).

These showed clear group separation in Principal Component Analysis (PCA) (and OPLS-DA, with a highly significant model (R2X(cum) = 0.629, Q2(cum) = 0.648, p = 5.5 × 10 -12 ), achieving 91% prediction accuracy and 100% specificity and an AUC value of 0.964.

In support of their tissue of origin, ingenuity disease and function pathway analysis of the differentially expressed genes between Ly6C hi TAMs or F4/80 hi TAMs versus colonic lpMFs revealed highly significant enrichment for pathways associated with gastrointestinal tract cancer and tumors (Ly6C hi TAMs: p-value = 5.6E-12, activation z score = 2.68; F4/80 hi TAMs: p-value = 1.1E-09, activation z score = 2.5) and with intestinal inflammation (Ly6C hi TAMs: p-value = 9.2E-11, activation z score = 2.38; F4/80 hi TAMs: p-value = 8.3E-07, activation z score = 2.68; Table S3).

One‐way ANOVA indicated highly significant differences in TPC across storage times for all extracts ( C. tamala : p = 5.60 × 10 −12 ; C. longa : p = 6.13 × 10 −25 ; Z. aramatum : p = 3.71 × 10 −45 ).

The correlation between the proliferation rates predicted by these models and those measured experimentally is highly significant (Spearman R = 0.44, p-value = 5.87e-12, Figure 2A–B , Supplementary file 1C and Supplementary file 2B ).

The search for variants associated with ER status showed only one region with a highly significant association, corresponding to FGFR2 (best p-value for rs3135718 p-value=6.0×10 −12 , Figure 1 and Supplementary Figure S1 ).

The composite score of 7 transcripts was highly significant between groups (p = 6.02 × 10 −12 ), and a simple linear prediction model yielded a receiver-operator curve (ROC, via JROCFIT [ 23 ]) with a C-statistic of 0.873, sensitivity of 77.4%, specificity of 83.7% and overall accuracy of 80.2%, with a positive predictive value (PPV) of 85.4% and negative predictive value (NPV) of 75.0% (Fig. 4 , Lower Right Panel).

The difference in GC% between genes with decreased TE in ATRA and insensitive genes was highly significant ( p = 6.1 × 10 −12 ) and a difference in the distribution of GC% from genes with increased TE was also notable compared with the insensitive pool ( p = 5.2 × 10 −5 ; Figure 4 E).

Removing gaze content resulted in a large and highly significant degradation of model fit (Δ−2 log L = 58.36, df = 4, P = 6.4 × 10−12).

Tukey’s HSD revealed that the difference between WT Dox (+) and G175S Dox (+) was statistically significant ( p = 3.36e-5), and there was a highly significant difference between G175S Dox (-) and G175S Dox (+) ( p = 6.635e-12).

This difference was slightly greater and still highly significant 15 weeks post-tumor initiation (Fig. 1F and Supplementary Fig. 3C ; P < 7 × 10 −12 ).

Comparing this dataset with our predictions showed a highly significant correlation (hypergeometric P -value<7 × 10 −12 ), though with precision and recall levels lower than those described above versus the kinetic RBC model ( Table I ).

This polyvariable linear regression equation, composed of weighted methylation level of three CG sites, was highly significant for the prediction of Gleason score in PCa patients ( r = 0.89, p = 7.1e − 12 ) as demonstrated in Fig. 3 a and b.

Of note, the SNP rs4810479 ( PLTP ) generated a P value of 1.51×10 −4 for HDL-C among European Americans and was highly significant among women ( P = 7.11×10 −12 ) but not men ( P = 0.12).

Importantly in an additive model with the other four drugs cannabis use is highly significant (β-estimate = 0.45 (0.32, 0.57), p = 7.24 × 10 −12 ).

The great majority of transcripts involved in fatty-acid and amino-acid metabolism were mitochondrially localized, with highly significant overlap between all three pairwise comparisons (single-test hypergeometric P -values—mitochondrion/fatty-acid metabolism overlap: P =7.4e−12; mitochondrion/valine–leucine–isoleucine degradation overlap: P =6.2e−22; fatty-acid metabolism/valine–leucine–isoleucine degradation overlap: P =3.1e−9).

The terminal child term, GO:0007156 (homophilic cell adhesion via plasma membrane adhesion molecules), had 17 of 163 genes differentially methylated and was highly significant ( p = 7.49 × 10 –12 ).