“highly significant”

Compared with the projected coordinates of southern Chinese, the mean shift toward Malays was insignificant for SG Chinese ( P = 0.31, t -test) but highly significant for Peranakan Chinese ( P = 7.5 × 10 −12 , fig. 1 D ).

Individual MMR Gene and Combined dMMR Survival Analysis A six-group log-rank analysis comparing MLH1 -mutant ( n = 18; 2 events, 11%), MSH2 -mutant ( n = 27; 1 event, 4%), MSH6 -mutant ( n = 46; 6 events, 13%), PMS2 -mutant ( n = 12; 1 event, 8%), POLE -mutant ( n = 63; 4 events, 6%), and TP53 -mutant ( n = 880; 373 events, 42%) subgroups demonstrated highly significant OS differences (log-rank p = 7.66 × 10 −12 ; Table 2 , Figure 3 ).

Milking number had a highly significant effect on concentration (F 1,219 = 52.36; p = 7.7 × 10 −12 ), reflecting the overall decline of residues over time.

In this internal validation , we found highly significant stratification of risk, including for deaths from cancer, which had an adjusted hazard ratio of 3.8 (95% confidence interval 2.59–5.57, p = 7.82 × 10 −12 ) between the lowest and highest quintile (Table 3 ).

For trait Q1, C4S4935 ( VEGFC ) explained a highly significant proportion of the variance (33.1% in family 7, p = 7.9 × 10 –12 ; 10.6% in all families combined, p = 1.1 × 10 –16 ).

A paired t test on measurements at 0.8 and 2.0 m above the ground for all PDT deployments less than 5 m from the kerbside (a working definition of ‘roadside’ for local air quality assessment (Defra 2009 )) demonstrated highly significant evidence for a difference in NO 2 concentration between the two heights ( p = 8 × 10 −12 , n = 84, Table 1 ).

Other important and highly significant categories were response to stress (1514 genes, padj-value = 5.69E-24) and developmental process (1280 genes, corrected p -value = 8.09E-12).

We repeated this test using human RH and mouse aneuploidy data (1,213 orthologous genes) and found a highly significant overlap of 131 genes with negative cis α ( P = 8.2 × 10 -12 ).

Four probands had rare damaging mutations (2 de novo) in TFAP2B , a transcription factor that orchestrates neural crest cell migration and differentiation; this mutation burden is highly significant ( P = 8.2 × 10 −12 ).

STRING protein interaction analysis yielded a highly significant protein-protein interaction (PPI) score (PPI score p = 8.26e- 12 ), suggesting these proteins might directly interact or work together in common pathways (Fig. 1 D).

Group differences in PANSS-EC total score were highly significant with OR 1.2, FDR-adjusted p = 8.3 × 10 −12 .

Bmp6 mutants showed a highly significant ( P = 8.5 x 10 −12 ) decrease in the expression of stickleback orthologs of these genes ( Fig 6E and 6F ).

The correlation between our CNV prediction and PCR validation was highly significant (P = 8.92E-12) (Additional file: Figure S2 ).

Although highly significant (one-sided Pearson P = 9 × 10 −12 for RSA and P = 2 × 10 −4 for DTL), the magnitude that ns-polymorphism distributions shift with respect to DTL and RSA was subtle: Across samples, the mean DTL of ns-polymorphism varied by less than 1 Å, and the mean RSA varied between 0.34 and 0.38.

Interaction of the proteins from the protein-coding genes seen in Figure S2 revealed a highly significant network ( p = 9.04 × 10 −12 ) with 76 connections, an average node degree of 2.53, an average local clustering coefficient of 0.382, and a maximum interaction score of 0.50.

Phonophobia was reported by 90.32% of dVM patients during the IC phase, but only 6.45% in the II phase, indicating a highly significant difference ( p = 9.336 × 10 −12 ).

The interaction was highly significant ( P = 9.52 × 10 −12 ), confirming that difference in gene expression between the vertically inherited homolog and donor ortholog is significantly greater in putatively stable laterally acquired genes than in degenerating ones.

The difference in the FCI between the two species is highly significant (two-sided t test P = 9.796e-12).

Results Pooled results indicated a highly significant association between COMT Val158Met and antipsychotic response (Z = 6.709, P = 9.8 × 10 -12 ).

However, we obtained a highly significant HWE deviation (P=9.8×10 -12 ) in the control group.

The overlap in these 83 genes was highly significant by the hypergeometric test ( P < 9.87e-12).

The overall differences between the incidences of the tested neuronal markers among the virus delivered eGFP expressing neurons were highly significant, the Kruskal Wallis H test between groups: Hdf = 61.2, p < 1e − 11.

The usual care plus albendazole arm continued, however, to show a highly significant difference in weight gain (2.8 [SE 0.1] kg vs. 3.8 [SE 0.1] kg, difference 1.0 [SE 0.15] kg, p = 10 −11 ), with the dewormed children exhibiting a 35 (SE 5) % higher weight gain.

Highly significant differences were observed in the level of clustering, or transitivity ( F = 86, p = 10 −11 ), however, with the antigens showing strong clusters separated from each other.

Expanding the observation to cells that showed morphological changes, including elongation, that preceded divisions, another 87 cells appeared to be preparing for division in aggregates while none of the isolated cells showed any shape change, which was a highly significant difference (24.3% vs 0%, two-sided p< 10 - 11).