“highly significant”

For OtV-type 2a, Ka​/Ks ratios were consistently >1 across all models, with highly significant P -values (average of ω = 1.3 and a P -value = 3e-155), indicating strong diversifying (positive) selection.

Using the same Mann–Whitney U test, we find a corrected p -value to be highly significant when comparing LD-18 and HD-18 samples ( p -value = 4.78–153).

In particular, 22 and 17 elements were detected for microRNAs 128 and 138 MREs, respectively, with a highly significant enrichment ( P < 1E −150 , Supplementary Figure 3 and Supplementary Table 3 ).

For five quantitative traits (BMI, DBP, FEV, RHR, and SBP), per-standard deviation (perSD) Beta values for rvPRS showed highly significant associations (max P = 1.21E-149; significance threshold P < 1.26E-04 = 0.05/18/22).

\usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar{w}\left({n}_{{wt}}\right)=$$\end{document} w ̄ n w t = 0.48, a difference that is highly significant ( P = 3.8 × 10 −148 , two-sided Mann–Whitney U = 43,750, n = 681).

The precision of this alignment was further quantified, showing a 74.5% overlap between high-risk and tumor cell categories, with McNemar’s test 84 demonstrating a highly significant association ( P = 3.54 × 10 −146 ) (Fig. 5 d), thereby supporting SIDISH’s accuracy in identifying cellular drivers of poor prognosis within their spatial context.

5 G) included 773 genes, which is highly significant ( p = 8.5 × 10− 142 ) with a strong odds ratio of 10.27, indicating that the overlap is about 10 times more frequent than would occur by chance.

In particular, the fluorescence intensity of SUVs preferred by 15GALA-NP increased approximately 2 orders of magnitude compared to free GALA, showing highly significant skewness ( p = 1.12 –141) by comparing the two distributions in a two-sided Welch’s t -test.

The APOE genetic signal remained highly significant in an age-stratified GWAS, on participants with age 60 years or more (OR 1.7, 95% CI 1.63–1.77; P = 2.7 × 10 −141 ; Extended Data Fig. 6 and Supplementary Table 2 ).

The Steiger analysis demonstrated highly significant directional associations for CEP68 using both blood ( p = 1.92 × 10 −137 ) and LAA ( p = 4.88 × 10 −49 ) eQTLs.

This overlap is highly significant by factor of over-representation (4) and P -value ( P < 3.1 e-136).

Figure 7B shows there was a highly significant overlap between the genes affected by cordycepin in the two cell lines ( P < 1.44 × 10 −135 by one‐tailed Fisher's exact test).

Furthermore, the Z-score-based meta-analysis of 1,239 animals in the exploratory cohort revealed a highly significant negative correlation between pH and lactate levels at the individual animal level ( r =–0.62, P =7.54 × 10 –135 ; Figure 1B ).

In fact, the correlation between hearing and deaf regional thickness measurements was highly significant (p = 6.85 × 10 −132 ), demonstrating an R 2 value of 0.98.

Changes to plan shape Throughout the entire handaxe sample, the correlation between tip length and PC1 ( Fig 14 ) is highly significant (r = .642, p = 1.2889E-128), supporting an allometric relationship between handaxe shape and size.

The correlation between total viral genome copies and sub-genomic E gene copies was highly significant ( p = 3.81 × 10 −127 ), but a high level of variance was observed between live viral titres measured by focus forming assay and both total and sub-genomic RNA titres ( Figure 4 a).

[ 19 ], 244 were significantly positively correlated to YAP1 expression in the GSE45547 expression dataset, demonstrating a highly significant enrichment ( Figure 6 B; Hypergeometric test, p = 1.961398 × 10 −122 ).

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

1c and 1d ) is highly significant ( χ 2 test-statistic = 548.68; d.f. = 2; N = 1,913; P = 7.2 × 10 −120 ).

Statistical analysis showed that there was a strong and highly significant negative correlation between the rate of change in expression and chimeric frequency (Pearson: r = −0.556, p = 4.69 × 10 −119 ; Spearman: r = −0.601, p = 7.34 × 10 −144 ).

Although we cannot rule out the possibility that widespread shallow oscillations persisted, a comparison between the same genes in Ctrl and SCNx groups showed a dramatic and highly significant (Wilcoxon signed-rank test, P = 8 × 10 − 114 ) decrease in amplitude after SCN lesion (Fig. 1 L, left).

The coefficient of linear correlation between the input and output signals was r = 0.9421, and it was highly significant ( p = 1.46 × 10 –111 ).

Meta-analyses of cis -eQTLs for brain-related traits show at least one variant in the ANKDD1B gene to be highly significant in the cortex ( P = 3.18×10 -110 ; Table F in S1 Table ) and nominally significant in the hippocampus ( P =.003; Table G in S1 Table ) [ 26 ].

As anticipated, lipid ratios capturing PUFA synthesis, namely PE(P-16:0_18:2)/PE(P-16:0_20:4), PE(P-18:0_18:2)/PE(P-18:0_20:4), PE(P-16:0_18:3)/PE(P-16:0_20:5) and PE(P-18:0_18:3)/PE(P-18:0_20:5), exhibited highly significant associations with FADS1/FADS2/FADS3 loci [575 SNPs; top hit: rs174564 for the PE(P-18:0/18:2)/PE(P-18:0/20:4); imputation r 2 = 0.999; beta = 0.49; p-value = 8.07 × 10 −107 ; p-gain = 2.60 × 10 +83 ].

Bioinformatics analysis of training cohorts identified a 61-gene signature that was highly significantly associated with RFS (HR = 37.08, P = 2.68*10 −106 , sensitivity = 89.29%, specificity = 89.61%, and AUC = 0.937).