“highly significant”

Significantly, we observed highly significant (p<4×10 −9 ) and positive (R 2 >0.80) correlations between levels of differentially-expressed transcripts identified in the presence of ouabain and K + -free medium ( Fig. 4 ).

Indeed, comparison of genes near Ino2-MN sites with genes near Ino2 ChIP-exo peaks ( 36 ), revealed highly significant overlap (adjusted P -value = 4 × 10 −9 ; labeled INO2* in Figure 3B ).

The overall preference for cortical ripples to lead hippocampal ripples during waking compared to NREM was highly significant ( P = 4 × 10 −9 , χ 2 = 34.5, df = 1).

A highly significant variant, g.10818413 T > C , located in the promoter region of EDN3 , was identified ( P < 4.065343e-09).

Given the large number (>1 × 10 7 ) of highly significant variants following multiple-testing correction ( p < 4.07 × 10 −9 ), we consider a Chi-Square value in or above the 75th percentile across all MESA participants as evidence of ancestry-differentiated allele frequencies.

This effect was highly significant (HR 4.778, 95%CI: 2.837–8.046, p = 4.08x10 -9 ).

The overall distribution difference between the two groups was highly significant (p=4.17 × 10 − 9 ) ( Table 4 ).

This overlap was highly significant by the hypergeometric test, confirming that ZEB1 -correlated genes are likely to be regulated by ZEB1 transcriptional activity (1.5-fold enrichment, p = 4.20 × 10 −09 ).

The difference was highly significant (log-rank p = 4.22 × 10^−9), indicating the model’s classification of patients in terms of likely therapy response correlates strongly with actual survival.

Diseases and functions annotation revealed a statistically highly significant overlap with energy production and lipid metabolism ( P = 4.3 × 10 −9 ).

For this total ingested NP, a highly significant positive linear relationship with dose was obtained (LR, p -value = 4.37 × 10 −9 ) with a multiple R -squared of 0.89 ( Fig. 2C ).

We mapped a highly significant QTL on chromosome 7 for cued immobility ( P = 4.40 × 10 -9 ).

Overall, the enrichment of origins near replication peaks is highly significant ( P = 4.41 × 10 -09 ).

A two-way repeated measures ANOVA revealed a highly significant interaction ( F 1.9, 28.8 = 69.5, P = 4.5 × 10 −9 , Greenhouse-Geisser correction applied) between regions (EVC, VTC, OFC) and property type (visual feature, animacy, valence).

One‐way ANOVA indicated that site ID was a highly significant predictor of diversity variation among samples for the Chao1 index ( F 12,75 = 7.66, p = 4.75 × 10 −9 ), and a marginally significant predictor for the Shannon index ( F 12,75 = 1.87, p = 005).

On the other hand, the average sleep intensity in the dark period between flies fed with the different diets showed clearly observable and highly significant differences (p < 4.76 E-09 ) ( Figure 2B and 3A ), suggesting that sugar-only diet resulted in an increase in rest intensity at “night”.

Then, we predicted the responses from cell lines that were not part of the training set, obtaining a highly significant prediction with a Spearman’s ρ of 0.64 ( p = 4.8e‐9; Figure S1 ).

islandica ( p = 0.117), but shell growth was highly significant ( p = 4.8 × 10 −9 ). 4.

Association between the nonsense mutation in homozygous condition and the presence of red spots in Girgentana goats was highly significant (Fisher exact test, P = 4.8e-9), even if not complete.

Indeed, there was a highly significant overlap between the proteins that increased during the 3 rd trimester and decreased post-partum (13/33 proteins, odds ratio (OR): 98.9, p=4.85e-09, Fisher’s exact test, Figure 4B ) and, conversely, between the downregulated proteins during the 3 rd trimester and the ones upregulated post-partum (13/44 proteins, OR: 29.9 , p=1.73e-05, Figure 4C ).

This analysis revealed that 25 genes were up-regulated 1.5-fold or greater in both Tsc1 LOF and FOXO GOF expression profiles, which represents a highly significant degree of overlap (P = 4.9 × 10 e−009 ) as determined by calculation of the hypergeometric distribution.

A highly significant 20% of the genes targeted by PLZF/RARA have altered expression patterns ( P = 4.99×10 −9 , Fisher exact ) with 11% becoming down regulated and 9% being up regulated upon PLZF/RARA binding ( Figure 2a ).

All these reported associations remain highly significant even after accounting for multiple testing using Bonferroni correction and a stringent GWAS P -value threshold (nominally P = 5 × 10 −9 adjusted to 1 × 10 −9 for five individual GWAS).

KEGG analysis of this 372-gene set revealed highly significant NFIB-dependent pathways (focal adhesion p = 5*10 −9 , extracellular matrix-receptor interaction p = 5*10 −8 , axon guidance, p = 5*10 −8 and pathways in cancer p = 5*10 −4 ) shown in Figure 4B .

A number of highly significant associations ( P < 5 × 10 −9 ) were identified in regulatory sequences which are good candidates for causing susceptibility to AS, possibly by regulating ERAP1 expression. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf n