“highly significant”

This difference was highly significant ( p = 0.0045; unpaired t -test).

In total, five out of the 11 p9 sites show highly significant differences ( P < 0.0045; Additional file 1 : Table S4; Fig. 1c for p9 sites 1610, 5520, and 7526).

Overall, we observe a highly significant difference in survivorship between CCL3L copy classes in the combined data stratified by origin ( p = 0.0045 for two categories and p = 0.0174 for three categories; see Figure 3D and 3E ).

The decline in VEGF levels in CMNS were highly significant compared to the HC, MM and CMS groups (p < 0.0045).

The ratio of CC3-positive to AP2-positive spots revealed a highly significant increase in the percentage of CC3-positive spots in the first arch of Clpex mutants (n = 2 or more sections from 3 WT and 6 Clpex mutants; Figure 6Q ; p=0.0045) We also observed apoptosis in the cranial neuroepithelium bilaterally at the dorsolateral hinge points in mutant sections ( Figure 6O,P ).

We also found a highly significant enrichment (adjusted P = 4.5 × 10 −3 ) for the top-level mammalian PO term hearing/vestibular/ear phenotype (MP:0005377).

3 ), with a highly significant change in tRNA fragment levels between the NAFLD and control groups: tRF-Val-CAC-005, 3.7-fold change ( p = 0.0045); tRF-Ala-CGC-006, 4.1-fold change ( p = 0.0027); and tiRNA-His-GTG-001, 2.42-fold change ( p = 0.0096).

Similarly, the 5-HIAA content was the highest in the ER group, with highly significant differences compared to the control and the 4 h -exercised (EE) snails (Kruskal-Wallis test: H (3, N = 46) = 13.08, p = 0.0045, Figure 4 , the third group of bars, post hoc tests ER/Cn p = 0.029; ER/E p = 0.49; ER/EE p = 0.004; E/Cn p = 0.9; EE/Cn p = 0.85).

Statistical analysis demonstrated that the difference was highly significant ( p = 0.0045).

The matching cluster and Robinson-Foulds tree metrics were utilized to calculate host phylogenetic and virome dendrogram topological congruence, which is highly significant based on both metrics with 100,000 randomly bifurcating trees to simulate stochastic virome assembly ( 1 ) ( P value = 0.00451).

In addition to Trp53 , 37 activated p53 target genes were overexpressed in the Lu-pos cell population, revealing a highly significant overlap ( p = 4.52 × 10 −3 ) between these gene sets (Additional file 1 : Figure S1c).

Compared to baseline we observed a highly significant increase in both serum CRP (baseline: median CRP = 6.0 mg/l; POD1: median CRP = 52 mg/l, P = 4.55E-03) (Fig. 1A ) and IL-6 (baseline: median IL-6 = 6.6 pg/ml; POD1: median IL-6 = 121.7 pg/ml, P = 7.23E-06) (Fig. 1B ) at POD1.

Based on the cluster analysis we identified two main patient clusters: one main cluster that included most patients with increased CRP levels and another including most patients with normal/low CRP levels; this difference was highly significant (Chi Square test, χ 2 = 8.02, p = 0.0046).

There is a highly significant relationship between the RCI values obtained for the mothers and those obtained for their daughters ( P = 0.0046).

Notably, PTE-Tw80@PDs exhibited superior protective efficacy compared to TiO 2 , as evidenced by a highly significant difference ( p = 0.0046).

Two (MET, PDGFRA) out of the three targets (MET, PDGFRA and PYK2) were experimentally validated as sensitizing targets of AKI-1 in the pancreatic cancer, representing a highly significant enrichment (hypergeometric test, p = 0.0046) ( Figure S4 in [55] ).

The delay was notably longer for chimera 264 (89 min) than sANTXR2 (77 min), and the difference was highly significant ( p = 0.0046), suggesting increased therapeutic potency of the multivalent particles over monomeric sANTXR2 as an inhibitor of the anthrax toxin.

Using the mean values of resistance and compensatory ability for each variety, we found a highly significant negative correlation between resistance and compensatory ability (Pearson’s r = –0.9954, p = 0.0046, d.f. = 2; Figure 7 ).

Sidak’s multiple comparison test revealed a highly significant difference between the neuronal cross-sectional area of STN neurons in control rats and those ipsilateral to the lesion at 5 months (P = 0.0046), and a more moderate difference at 1 month post-lesion (P = 0.0443), suggesting that the cross-sectional area of STN neurons is reduced between 1- and 5-months post-lesion.

patients using Fisher’s Z test yielded a highly significant difference ( Z = 2.83; p = 0.0047, two-tailed) [ Note : When using Spearman’s correlations without outlier detection, this pattern remained qualitatively unchanged (controls: ρ = 0.559, p = 0.0103; patients: ρ = −0.339, p = 0.1990)].

A highly significant positive correlation was seen between chemerin and total body fat ( r = 0.4492; P = .0047), 2hPGPG ( r = 0.5755; P = .0021), HbA 1c ( r = 0.4187; P = .0058), TGs/HDL-c level ( r = 0.5491; P = .0001), and a partially significant correlation was seen with waist circumference ( r = 0.2863; P = .0733) ( Fig 2 and Supplementary Table S2) [ 20 ].

A highly significant moderate negative correlation (r=−0.5183, P=0.0047) was observed for the HIV+ group, demonstrating that as TEAC increases, TBARS concentration decreases.

Similarly, the Iba1 integrated density was reduced by 36.8 percentage points in the cone-shaped group (85.4% ± 10.5%) relative to the bare group (122.2% ± 9.2%), showing a highly significant difference (p = 0.0047).

Notably, all GBA-NMC individuals who were identified as prodromal PD, based on the MDS research criteria 16 , had the abundance of coherent PD-enriched species above the median, a highly significant bias ( χ 2 test, P = 4.7 × 10 −3 ), and four were at the very top of the distribution (Fig. 3 ; P = 5.7 × 10 −4 ).

However, for beat sequence lengths 5000 and higher, the difference was highly significant (p ≤ 0.0047).