“highly significant”

However, for beat sequence lengths 5000 and higher, the difference was highly significant (p ≤ 0.0047).

Again, the effect was highly significant ( r = −0.65, p = 0.0047; Figure 2C , inset).

The interaction of the percentage of section limitation with the diameter of the arterial cannula was highly significant ( p = 0.00478).

Likewise, the increase of NfL within each group from baseline to 90 months was also highly significant using NfL z‐scores (AD: p = 4.8 × 10 −3 , controls: p = 3.6 × 10 −11 ).

Differences in vimentin expression between the clones were highly significant (p < 0.0048; Kruskal Wallis statistics = 14.94; df = 4).

Interestingly in the eRA synovium from PEAC study, the correlations between baseline GZM A and DAS28-ESR were positive and highly significant ( r =0.31, p=0.0048) ( Fig. 3A ), GZM B and DAS28-ESR ( r =0.29, p=0.0077) ( Fig. 3B ), GZM K and DAS28-ESR ( r =0.33, p=0.0031) ( Fig. 3C ), GZM H and DAS28-ESR ( r =0.27, p=0.015) ( Fig. 3D ), GZM M and DAS28-ESR ( r =0.33, p=0.0023) ( Fig. 3E ), PRF-1 and DAS28-ESR ( r =0.39, p=0.00033) ( Fig. 3F ), SRGN , DAS28-ESR ( r =0.31, p=0.054) ( Fig. 3G ) and CD27 ( r =0.30, p=0.007) ( Fig. 3H ).

This was a highly significant difference ( p = 0.0048, Fisher’s exact test) in mortality between the Venus control and the combined vaccine groups.

The left hippocampus of patients also resulted smaller (3202.9, SD 2795.9) than that of controls (6137.5, SD 3079.9); this difference resulted highly significant ( F = 9.052; p = 0.0048; lambda = 8.31; power = 0.82).

The knockdown of each kinase caused a drastic and highly significant decrease in clonogenic survival (Fig. 3 ), an effect that was independent of AurkA polymorphism (Cal27 - siAurkA p = 0.0048, siAurkB p = 0.0084; HN - siAurkA p = 0.0004, siAurkB p = 0.0076).

To assess the statistical significance of this finding, we performed a simulation with a null distribution of 10,000 trials of 129 genes chosen at random and found the overlap to be highly significant ( P = 0.0048).

Strikingly, we find that DS subjects exhibit a highly significant age acceleration effect in three independent data sets ( P = 0.0048, P = 5.5×10 -7 , P = 0.00056 Fig. 1e – g ) involving blood and brain tissue.

Importantly, a highly significant, inverse relationship between the plasma concentration of Fgl2 and both the frequency ( P = 0.0048) and absolute number ( P = 0.0044) of total CD8 + T cells was observed in patients with COVID-19 ( Figure 4B ) that was not observed in healthy controls ( P = 0.9; Figure 4B ).

Upon statistical normalization of the TG levels using logarithmic transformation, due to the wide baseline range (Figure 3A ), a highly significant decrease was observed following administration of aleglitazar (Figure 3B ; P = 0.0048).

Fifty percent of animals treated with 5 μg of VLP survived, but inclusion of either 10 or 1 μg of polyICLC increased survival to 100%, which was also a highly significant increase (p = 0.0048) ( Figure 1C ).

As a less conservative estimate, directly sampling from the universe of SNPs and estimating the probability of observing at most two derived SNPs and a mean AF as large as the empirical variants of interest produced a highly significant P -value = 0.00487 ( supplementary fig.

This difference was highly significant (P = 0.0049).

Analysis of semantic enrichment from other database such as Swissprot PIR keywords and Interpro did provide highly significant enrichment of terms such as 'metal-binding' (67 genes, P = 0.0049), 'metalloprotein' (12 genes, P = 2 × 10 -5 ), 'zinc finger, NHR/GATA-type' (6 genes, P = 8.8 × 10 -4 ), 'iron' (13 genes, P = 0.0023), and 'cytochrome P450' (7 genes, P = 0.0019), whilst weaker associations with terms included 'calcium-binding EF-hand' (11 genes, P = 0.015) and 'calcium' (22 genes, P = 0.029).

The CHX-treated specimens showed a highly significant reduction ( P < 0.0049) in the number of microbes after instrumentation and irrigation.

When comparing Group 1 (5, 7.5, and 10 mm; mean = -7.21 ± 3.74) and Group 2 (12.5, 15, 20, and 25 mm; mean = -0.23 ± 1.13), a highly significant difference was found ( p-value = 0.0049).

This association was highly significant both in patients who underwent optimal (HR = 0.74, P = 0.0049) or suboptimal surgery (HR = 0.63, P = 5.7e‐05).

The significance thresholds were as follows: P < 0.05 (*significant, *), P < 0.01 (**highly significant, **), and P < 0.005 (***extremely significant, ***), with additional asterisks denoting increasing levels of significance.

There was a highly significant relationship between clonal diversity R and inbreeding F across sampled meadows for the whole dataset (Spearman correlation, r s = 0.63, p < .005) and based on MLGs only (Spearman correlation, r s = 0.52, p < .001).

This difference was highly significant (P = 0.005).

Our result is highly significant at the 1% level (p-value=0.005 in the multivariable analysis), which compares with a significance level of 5% (p-value=0.049 when temperature is over 7°C) in R an et al .

After the intervention, there was a significant sudden change in departments 2 and 4, and in department 4 this change was followed by a highly significant increase in the trend to estimated 109.4% per year (p = .005). 3.1.2 Neuromuscular monitoring after non‐depolarising NMBAs A positive pre‐intervention trend in use of acceleromyography in cases involving a non‐depolarising NMBA was found in the analysis of all departments as a whole, with a calculated estimate of 4.8% per year ( p < .001) (Figure 4 ).