“highly significant”

There were highly significant correlations between the FDDB and PRODI ® tools for daily energy and macronutrient intakes (correlations ranging from 0.849 to 0.929; p ≤ 10 −8 ) ( Table 2 ).

This enrichment is highly significant ( p = 1 × 10 −8 ), especially when considering that all miRNAs may not necessarily disrupt transcript levels.

There was no significant difference in the family effect between years (interaction family × year not significant; LRT: χ 2 = 1.2; df = 2; p = .552), but the family effect was highly significant ( χ 2 = 32.6; df = 1; p = 1 × 10 ‐ 8 , Table S2 ) and the heritability of the sensitivity to vernalization was 0.19 (±0.04) (Table 2 ).

We recovered the PCDH15 locus as a highly significant sweep region consisting of more than 300 variants spanning 369.5 kb ( p -value < 10 –8 ), indicating a strong signature of selective sweep.

Notably, the gene candidates THBS1 and IL18RAP exhibited highly significant upregulation (LogFC > 1.9, p < 10−8) in the independent GSE28750 cohort, confirming that our network-based prioritization captures clinically relevant expression changes.

Using the selected model, the R, G, B variable coefficients ± SEM were all found to be highly significant ( p < 10 −8 ) and estimated at β 1 = 0.080 ± 0.0152, β 2 = −0.722 ± 0.0174, β 3 = 0.543 ± 0.0140, respectively, implying a minor contribution of the R variable to positive pixel predictability and a substantial but reciprocal effect of the G and B variables.

The association of this subset of taxa with the target phenotype was highly significant ( p -value < 10 –8 ).

The effect size of the differences observed is very large, and the P -values highly significant ( P < 10 −8 ).

Compared to peaks containing L-CTCF-BSs, P-CTCF-BSs exhibited a higher mutation rate of 1.34 and 1.25 times per CTCF-BS for LNCaP and MCF7 respectively ( Supplementary Table S4 ), and the elevated rate is highly significant ( P -value < 1 × 10 −8 ) as determined by a permutation test (Materials and methods) (Figure 2A , B ).

While we found no obvious and consistent correlations between GWAS gene significance and FCs (electronic supplementary material, figure S4 a–g ), we identified GRIN2A and KCNB1 with highly significant GWAS associations ( p < 10 −8 ) in all seven diseases, and more strongly upregulated TL (FDR < 0.05, log 2 FC (TL/FL) > 1) in either both INH/EX ( GRIN2A ) or in INH ( KCNB1 ) ( figure 1 f,h ).

A highly significant relationship was observed between cytokinin dose and GUS activity ( n =119, F =37.99, P =1.02 × 10 −8 , R 2 =0.24) ( Figure 6C ).

This overlap between FMCD genes and the cilia disassembly pathway identified here is highly significant ( P = 1.06 × 10 −8 , Fisher’s exact test; Fig. 5A ), prompting further investigation.

Of these, 19 were expressed in platelets, and String analysis showed a highly significant PPI enrichment ( p = 1.08e- 08).

The correlation between lineage and average sperm length for all 33 males was highly significant (r = -0.811, n = 33, t 31 = 7.71, p = 1.1E-8).

A Kruskal-Wallis test showed a highly significant difference in water collection times between the kebeles in both wet season (chi-squared = 40.0, p = 1.1 × 10 −8 ) and dry season (chi-squared = 42.3, p = 3.5 × 10 −9 ) ( Fig. 3 ).

As expected, a two-sample t -test performed on these raw data confirmed that there was a very highly significant difference between the mean whole-blood HbA1c levels of these two groups ( p = 1.11 × 10 −8 ), with the T2DM one being much greater.

Despite the small sample number, these changes were highly significant ( P values in a 1-way ANOVA: DUSP11 : 9 hours: P = 1.11 × 10 −8 ; 24 hours: P = 6.27 × 10 −13 ; SRRM1 : 9 hours: P = .00031; 24 hours: P = 1.47 × 10 −9 ).

421.33 ± 8.80 pg/mL, respectively, and the difference remained highly significant after adjustment for age and sex ( p = 1.14 × 10 −8 ).

A separate Kruskal-Wallis test for geographical regions also indicated a highly significant effect ( H = 36.56, p = 1.141E-08), with Dunn-corrected comparisons confirming that both the Silesian Upland and the South Greater Poland Lowland differed significantly from the Silesian Lowlands ( p < 0.001), whereas their mutual contrast remained non-significant.

Most importantly in terms of coevolutionary dynamics, the interaction between mosquito species and parasite genetic population had a highly significant effect ( P = 1.191 × 10 −08 ; fig. 5 ).

For the same set of 1392 genes, the most highly significant canonical pathways were “Synaptic Long Term Depression” ( P = 1.2e-8), “Axonal Guidance Signaling” ( P = 3.4e-7), “CREB (cAMP response element-binding protein) Signaling in Neurons” ( P = 4.3e-7), “Neuropathic Pain Signaling in Dorsal Horn Neurons” ( P = 4.7e-7), and “Melatonin signalling” ( P = 5e-7).

The Kruskal–Wallis H test showed highly significant effects of water treatment on both plant height ( p =1.23×10 -8 ) and petiole count ( p = 4.40×10 - 12 ).

For the Breast Cancer Ultrasound dataset, even with a smaller average improvement (0.36%, SD ± 0.01%, CI [0.36, 0.37]), the p-value remained highly significant (p = 1.23e − 8).

Analysis of the strain differences produced highly significant results using both ANOVA and the non-parametric Kruskal-Wallis test (p-value = 1.25×10 −8 and 2.37×10 −5 , respectively).

This finding was highly significant, suggesting that individuals with poor sleep quality experience significantly more severe symptoms of IPD ( p = 1.25 × 10 −8 ).