“highly significant”

This is in accordance with Christoph et al .’s study, which reported a statistically highly significant ( P < 0.000001) result, showing non-buffered local anaesthesia to be 2.8 times more painful than buffered local anaesthesia.

As expected, we observed a highly significant, positive relationship between metabolic rate and body mass ( R 2 = 0.53, F 1,175 = 193.65, P < 0.000001; log-transformed data).

As expected, highly significant enrichment was observed in the mutant cells for ‘Wnt Receptor Signaling’ (p < 1e-6).

Upon initial analysis, the storage process demonstrated a highly significant effect (Hotelling multivariate p-value = 1 × 10 −6 ).

This analysis revealed a highly significant sensitivity ( p < 10 −6 ) of wave speed to incline, with each 1° increment in grade associated with a 1.9% increase in peak wave speed.

Highly significant differences in deconvolution performance, i.e., RMSE and Pearson correlation, were observed across all datasets, with p < 1e−6.

4.2.2 Performances of AEVA‐HE versus DermaTOP in study 2 When focusing on the crow's feet region extracted from both systems, using the same region of interest dimensions, comparable and highly significant results are obtained (Figures 12 , 13 ). “Sa” roughness parameter, ( r = 0.88) and for mean depth parameter ( R = 0.93) with p < 0.000001 in both cases.

1 a), which is further supported by a low but highly significant genome-wide estimate of genetic differentiation ( F st = 0.0021; p value < 10 −6 ).

Besides the obvious highly significant effect of age on age at onset and at diagnosis of RBD ( p < 0.000001), we found a significant effect of treatment with antidepressants on age at diagnosis of RBD, with antiD+ patients being on average 6.6 years younger than antiD− patients, with a large effect size.

There was a highly significant effect of Contrast (F (1,16) = 66.2,p<1e-6) on GR peak power, which is explained by a generally higher GR power in case of high, as compared to low, contrast.

For consistency, we also examined this relationship using the 1000 Genomes phase II data and found similar highly significant relationship between N e for homozygous SNVs ( P < 10 − 6 ) (Additional file 1 : Figure S1).

Genes differentially expressed in association with upl3‐5 are linked to stress responses and metabolism To identify the biological processes that were most likely influenced by the mutation in AtUPL3 in association with infection by cyst nematodes, we focused on genes that showed highly significant differential expression between the upl3‐5 mutant and wild‐type Arabidopsis plants (−log 10 ( P ) > 6).

2 ), of which two, on chromosomes 3 and 5, are highly significant ( P < 10 −6 ).

Highly significant differences ( P < 0.000001) were observed for both potassium and calcium relative to the other minerals (Fig. 10 ).

The overall model fit was strong, with a pseudo-R 2 of 0.438 and a highly significant likelihood ratio test ( P < 0.000001), indicating that the model explains a meaningful portion of the variability in patient outcomes ( Table 4 ).

3 for presentation of results) the region was also found to be highly significant ( p < 10 –6 , R 2 adjusted = 0.8).

In all cases, the difference in the level of divergence between normal and tumor samples in each tissue and platform cohort is highly significant (Wilcoxon P value < 10 − 6 ; see Fig. 2 ).

However, in the presence of added adenosine (3 or 10 μmol/L), guanosine (10–100 μmol/L) decreased proliferation of both cell types, thus resulting in a highly significant ( P < 0.000001) interaction between guanosine and adenosine on cell proliferation.

We observe a 4-fold enrichment of such ‘clustered’ informative sites, which is highly significant ( p <<10 −6 ).

Similarly, the marital status distribution (35 single individuals out of 40 cases) showed a highly significant deviation from the expected proportion ( p = 0.000001), suggesting that single individuals are at notably higher risk.

Box 1 Umbrella review evidence rating by strength of association Convincing Highly significant associations (P<10 −6 ) Cases of n >1000 I 2 <50% 95% prediction intervals excluding the null value Largest study nominally significant (P<0.05) No evidence of small study effects No evidence of excess significance bias Highly suggestive Highly significant associations (P<10 −6 ) Cases n >1000 Larg

A Chi-square test of independence indicated a highly significant dependence ( p = 0.000001) between cell type and localization of the signal within the cell.

This highly significant difference (2.1-fold; P ≤ 10 −6 ) suggests that some of the low-scoring sites might be false positives of the ChIP approach and that the overall prediction performance might have been underestimated.

The differences found were highly significant related to group B vs group A (χ2 85,63 p <0.000001; O.R. 2,69 [2,16-3,34] )and related to group B vs group C (χ2 33,1 p < 0.000001; O.R 2,39 [1,75-3,26]).

The analysis of the heat stress data also revealed that the number of highly significant genes (unadjusted p < 10 −6 ) increased with the number of included experiments.