“highly significant”

In Supplementary Data 6 , the association of CHRM3 activation with “urinary contraction” (literature ID 364) contains the p value and ROC AUC for “Urinary retention” and is classified as highly significant ( p ≤ 1e-06), with distance 1 (i.e., the significant PT and starting PT are connected via 1 intermediate in the network, via the shared HT).

A similar analysis of these genes demonstrated that they were clustered closely in diseases and had a highly significant p value < 10 −6 .

A highly significant positive correlation ( R = 0.43, P < 1 × 10 −6 ) between CHK1 and ZEB1 was observed in these breast carcinomas, in which 69% (89 of 129) of the tumors with high ZEB1 expression exhibited high CHK1 expression, and 77% (47 of 61) of the tumors with low ZEB1 expression showed low CHK1 expression ( Fig. 8b ).

As indicated by the far from overlapping confidence intervals (CI) for these estimates, the differences between the two dementia caregiver groups is highly significant ( t = 4.87, p < 1 × 10 -6 ).

Lastly, kDGF was a highly significant multivariable predictor of a higher CCI, even after controlling for the four other significant multivariable predictors of this outcome ( p < 0.000001, Table 5 ).

Briefly, meta-analyses were considered to be supported by robust evidence if the association was supported by more than 1000 cases, a highly significant association (the random effects model had a P -value ≤ 10 −6 , a threshold that is considered to substantially reduce false positive findings) [ 31 – 33 ], there was absence of high heterogeneity based on I 2 < 50%, the 95% PI excluded the null value, and there was no evidence of small-study effects or excess statistical significance.

Following previous umbrella reviews, 13 we considered as convincing the associations with>1000 cases a highly significant association (p-value<1 × 10 −6 ), no large between-study heterogeneity, no evidence of excess significance bias or small study effects, and a 95% prediction interval excluding the null value.

All TLE + uMTS patients demonstrated ipsilateral hippocampal T2 more than two standard deviations greater than controls (mean: 135 ms, range: 122–160 ms); these differences were highly significant (Student's t test, p < 0.000001).

The intra-correlations of IgE levels among newborn, 1.5, 3 and 6 years were highly significant correlated one another ( P <10 −6 ; Table 2 ).

When we analyzed the gene expression data set, this pathway was also enriched highly significant ( p < 10 −6 ).

This difference was highly significant ( U -test, p < 0.000001).

SNP with call rates < 0.98, minor allele frequencies (MAF) < 0.03 and highly significant deviations ( P < 10 -6 ) from Hardy-Weinberg Equilibrium (HWE) were also excluded.

After ranking the genes in the test and validation sets, we identified a signature of 95 highly significant ( P < 0.000001) differentially expressed genes (FDR = 0), which distinguished tamoxifen treated from untreated breast cancer patients ( Fig. 3 ).

The Spearman correlation coefficient highlighted a strong (ρ = 0.79) and highly significant (p<1e-6) correlation between the number of clones and the number of ribotypes.

The other primary variables, that is, height, age, age 2 , elevation and sex, were all highly significant ( P < 10 −6 in all cases).

The differences between MS and control findings was highly significant (p > 0.000001).

Significant differences were observed between the SIDS and non-SIDS groups: the presence of thymic petechiae in SIDS (89.5%) compared with non-SIDS (47.7%) was highly significant ( P < 0.000001; OR 9.38 (CL 4.5 to 19.9), and their absence was more frequent in non-SIDS (52.3%) compared with SIDS cases (10.4%) ( P < 0.000001).

Our results show a highly significant difference in response to radiation damage between DAOY cells grown in adherent conditions and DAOY spheres (Fig. 4 ; Table 4 , p < 0.000001).

The differences found were highly significant related to group B vs group A (χ2 85,63 p <0.000001; O.R. 2,69 [2,16-3,34] )and related to group B vs group C (χ2 33,1 p < 0.000001; O.R 2,39 [1,75-3,26]).

We find a considerable fraction (~30%) of Pol III-occupied loci reside within CpG islands, a highly significant overlap (p-value<10 −6 ), and a striking correlation exists between Pol III occupancy and CpG content at Pol II promoters.

This highly significant difference (2.1-fold; P ≤ 10 −6 ) suggests that some of the low-scoring sites might be false positives of the ChIP approach and that the overall prediction performance might have been underestimated.

6 B ), the differences were highly significant (paired t -test, df = 128, P < 10 −6 ).

The Friedman test yields highly significant P -values (F-measure: P = 1.009 × 1 0 − 6 , Accuracy: P = 6.852 × 1 0 − 8 , and F1 + ACC: P = 1.713 × 1 0 − 7 ), confirming statistically significant differences among the algorithms.

In all these analyses, we observed highly significant networks (p < 1.01E-06, p < 3.6E-14, p < 0.000975, respectively).

VitD-dependent DE genes in Teff cells from B6 females exhibited highly significant enrichment ( p = 1.02e−6) within genes downregulated in MS-CIS CD4 cells, while marginal or no enrichment was observed for genes that were upregulated in MS-CIS (Figure 3 E).