“highly significant”

A highly significant ( p = 2.2 × 10 −5 ) OPLS model could be built for the classification of samples by production year (model 8).

Post-Hoc analysis by Pairwise T-Test with Bonferroni-adjustment showed that there was a highly significant reduction in the ABZ and ABZ/BTZ-treated group as compared to the control (p = 2.2e-05 and p = 1.3e-06, Figure 8B ).

A role for cis -regulatory elements in methylation fidelity was also demonstrated by highly significant (p<2.2×10 −5 ) enrichment of transcription factor binding sites in CGI probe loci showing heritably high (118 elements) and low (47 elements) methylation, and also in loci demonstrating stochastic hyper-(30 elements) and hypo-(31 elements) methylation.

In this model (adjusted R 2 = 0.73), sample size had no significant effect on α ( β = −1.2e-04, p -value = 0.48), whereas IGRs showed a highly significant positive shift ( β = 0.137, p -value = 2.2e-05).

This enrichment of previously described vaccine candidates in our Vacceed set was highly significant (one-tailed Fisher’s Exact Test – P = 2.2 × 10 −5 ).

While One‐way ANOVA tests indicated minor statistical variations among the samples within the same channel (p = 0.0132 for the 1.0 mm channel; p = 0.0035 for the 1.6 mm channel), these maximum deviations (∼0.27 mm/s) were negligible compared to the highly significant performance shifts induced by variations in the environmental geometry (an absolute speed difference ranging from 1.8 to 2.3 mm/s, p = 2.27 × 10 −5 when comparing the pooled sample data between the two channels).

Expression of GABA-related genes positively correlates with viral load The effect of DWV load on GABA-related gene expression was highly significant in GR bees (GLM, MB DWV log 10 ; β est.=0.473, s.e.=0.108; t =4.365, P =2.28×10 −5 ) while this was not the case for BR bees (GLM, DWVlog 10 ; β est.=−0.248, s.e.=0.134; t =−1.849, P =0.067).

We observed highly significant effects in men (effect size or ES=(M TLS −M MLS )/SD pooled =1.15, p=2.3×10 −5 ) and women (ES=1.25, p=8.2×10 −4 ) in the expected direction corresponding to a three times higher consumption of game intake in those with a traditional lifestyle.

We employed standard ANOVA F-tests [ 59 ] to evaluate the significance of the interaction term (reflecting varying slope by treatment group) and found that the evidence did not support inclusion of the interaction term (P = 0.93) when comparing these two models, but when comparing the simpler model to the trivial model that ignores treatment group (adjusted R 2 = 0.75), the ANOVA F-test P-value is highly significant (P = 2.3e -5 ), supporting the inclusion of group-specific intercepts, but not group-specific slopes, in the final model.

For CS- tones, a highly significant increase in SSA occurred after conditioning ( Fig 4F , 16%, F(1,1801) = 18, P = 2.3*10 −5 ).

When testing the same networks with the top 900 and 850 strongest connections retained, E glob remained highly significant ( p = 2.31 × 10 −5 for 900 and p = 3.07 × 10 −5 for 850 links).

This increase of GSH plasma concentration was highly significant already after 1 h of preparation delay (paired Student’s t -test p -value = 2.34 × 10 −5 , Figure 1 A, left panel).

Nevertheless, the correlation between genetic diversity and geographic distance from Asia remained highly significant after controlling for the number of infections [generalized linear models (GLM), P < 2.37 × 10 −5 ].

The analysis demonstrated a highly significant increased effect size when stimulation was applied to subcortical strokes versus the mixed strokes ( p = 2.45598e−05, two-tailed Mann–Whitney U -test.) When sub-analyzed within the context of type of stimulation technique, this significant finding was reproducible for both rTMS and tDCS articles (rTMS p = 0.01115294 and tDCS p = 0.01428572, Mann–Whitney two-tailed U -test).

The coastal southern part of Cameroon had the lowest Bd burden with a highly significant decrease of cases over time (odds = 0.4, P -value = 2.5 × 10 –5 , Table 1 ).

The log-rank test showed a highly significant difference in MFS between patients with low (⩽0.81, n =62, 26.6%) and high (>0.81, n =171, 73.4%) ATM protein levels ( P =0.000025; Figure 1B ).

A linear model of incidence by commune on both IDH and Amerindian ancestry showed that HDI remained highly significant (p < 2.55e−05).

Pentapeptide-sharing was found to be highly significant between schizophrenia-related proteins and the hemagglutinin precursor (χ2 (1) = 17.723, p = .000026, two-sided).

3e ) the slope of the regression line was highly significant (F 1,1082 = 17.83, r = 0.179, p = 2.6 × 10 −5 ), as was the increase of the post-training slope relative to the pre-training one (F-test, F 1,2288 = 15.31, p = 0.0001).

The main effects of qDH3 , qDH6 , and qDH7 were highly significant (3.8 × 10 −15 < p < 2.6 × 10 −5 ) in both 2016 and 2017.

The correlation with OS was highly significant: HR = 2.2 (1.51–3.21) with 95% CI (log-rank p -value = 2.6E−05).

As expected, the LAMP analysis revealed highly significant evidences for both linkage (LOD = 5.19, p = 2.6×10 −5 ) and association (LOD = 45.88, p = 7.2×10 −48 ), and both the evidences are mapped to the HLA-Cw6 locus.

Its first component was found to have a highly significant correlation ( r = 0.77, p = 2.62 * 10 −5 ), as well as a steep relationship to PMA (slope a = 0.88), suggesting that global properties of the connectivity might also reveal robust developmental correlations.

In contrast, a higher minor allele frequency (15.6%) of the p.Leu1007fsX1008 (rs2066847) frameshift mutation was seen in patients with aggressive disease, compared to 8.2% in patients with mild disease which was highly significant (p = 2.63x10 -5 , Table 2 ).

Of all 1540 possible gene pairs, we found that a total of 226 pairs were significantly enriched beyond what would be expected by chance (hypergeometric test, Benjamini-Hochberg–adjusted, P < 0.05), with highly significant pairs such as Cdkn2a + Pten (co-occurrence rate = 7/10 = 70%; hypergeometric test, P = 2.63 × 10 −5 ), Cdkn2a + Rasa1 (co-occurrence rate = 6/9 = 67%; P = 7.96 × 10 −5 ), Arid2 + Cdkn1b (co-occurrence rate = 11/17 = 65%; P = 9.13 × 10 −5 ), and B2m + Kansl1 (co-occurrence rate = 11/18 = 61%; P = 3.6 × 10 −4 ; Fig. 5 , B and C, and table S13).