“highly significant”

Highly significant differences in plant growth (PRA29) were observed when flm-3 was complemented by either of the QTL alleles ( p = 2.638e−05).

The correlation between ALDH5A1 and beta-alanine was highly significant ( r = –0.24; p = 2.7 × 10 -5 ).

Methods Ligand binding site similarity between COMT and InhA Previously, the SOIPPA algorithm had revealed a highly significant similarity (p-value = 2.7e-5) between the NAD binding site of the Rossmann fold and SAM binding site of the SAM methyltransferases [11] .

As shown in Fig 5 , a highly significant correlation between LV active force σ and the Seattle 5-year score was found (R = 0.77, p = 2.7x10 -5 ).

The idh2 ∆ single mutant was 2.5-fold more resistant to fluconazole (IC50 = 59.4 ± 1.1 μg/mL) than wild-type BG14 (IC50 = 24.1 ± 0.9 μg/mL) and the difference was highly significant ( P = 2.8E-5, n = 3, Student’s t -test).

However, at 35 °C, all three segments had highly significant effects (one-way ANOVAs, p values ≤ 2.8 × 10 −5 ; Fig. 2f ).

The tumor-subtype and stage-dependent expression of JUN was highly significant when comparing healthy and primary ( p = 2.8e-05), primary and metastatic CRPC ( p = 2.6e-43) and primary and metastatic NEPC ( p = 5.3e-04) (Supplementary Fig. 1g), suggesting JUN as a potential marker of progressive subtypes of PCa.

NPA difference in peak ChBF increase with NTS stimulation was highly significant ( p = 0.028 × 10 3 ; Figures 6 , 8 ).

A highly significant relationship was observed between the RS and the likelihood of DM whether the RS was treated as a continuous (Wald test; HR = 2.76, Scaled HR; 5.65; p = 2.8 × 10 −5 ), or a binary (log-rank test: HR = 8.25; p = 8.0 × 10 −4 ) variable (Figure 1A ).

Consistently, a drop in dispersion test showed a highly significant decrease of dispersion upon incorporation of mean intraoperative dBP, liquid balance of length of surgery into the regression formula (F statistic 8.3912, p = 0.000028737), while the addition of mean intraoperative MAP had no further significant effect (F statistic 2.989612, p = 0.085425).

Histopathological findings across MVI cohort A highly significant association was observed between microvascular inflammation and C4d positivity (p=0.000029).

When the imbalances observed in our samples at the SNPs rs6983267 , rs961253 , rs3802842 , rs10411210 , rs4444235 , rs4779584 , and rs9929218 were combined with those published previously [19] , [35] , we observed a highly significant relative loss of the non-risk T allele of rs6983267 (p-value = 2.94×10 −5 ).

Regarding the comparison of IGRA results in disseminated versus other forms of tuberculosis, a previous multicenter study using data from collaborators from mainly high-income European countries found that in children with microbiologically confirmed tuberculosis IGRA sensitivity, when results were pooled for different versions of IGRAs ,was 70% (56/79) in those with disseminated versus 89% (283/315) in those with pulmonary tuberculosis, which we calculated was a statistically highly significant difference ( p = 0.00003).

In all cases, there was a clear bias of propagation in one orientation, which was highly significant ( P < 3 * 10 −5 ; 12 retinas aged P4–6; data not illustrated).

Furthermore, we also confirmed there was a highly significant correlation between MM and GS in this module (Cor = 0.47, p =3 e − 05) ( Figure 3(d) ).

However, the KNN classifier trained on the exonic subset of features showed no statistically significant difference in BCR-free survival using a log-rank test ( p < 0.08) whereas the difference was highly significant for the non-exonic KNN classifier ( p < 0.00003).

This highly significant enrichment of S-aromatic motifs within the low-reactivity group (p-value = 3 × 10 −5 ), allows us to conclude that the involved methionines exhibit a much lower reactivity than their non-interacting counterparts.

filters F3+F4; 365 SNPs in 396) (Table 3 ), a highly significant difference was found in the final number of SNPs recovered with call rates ≥ 95%, (Chi-square Pearson = 17.40; p = 0.00003).

For the multitalker babble noise (20T), we find that with the exception of SCNR all intelligibility improvements caused by the schemes compared with NoPre are highly significant ( p < .00003).

Nonetheless, the difference in tumor growth between +dox and -dox was highly significant ( p = 0.00003).

Consistent with this, regression of second component dopamine responses to cues (0.2–0.6 s after the cue onset) onto value estimates of the superior model was highly significant ( Figure 4B , right, R 2 = 0.93, p=0.00003).

Under this null model, there was a highly significant increase in the proportion of missense mutations on the ligand-binding interface (Fig. 3e , expected = 43%, observed = 64%, p = 3e −5 , n = 107, two-tailed binomial test, Supplementary Note 10 ).

Compared to the untreated control, both treatment protocols resulted in a highly significant reduction in viable cell counts (t-test, t (5) = 14.30, p = 0.00003, ***), corresponding to a ~ 4 log10 reduction (Figs. 6 and 7 ).

Compared with population data, enrichment of SIX1 loss-of-function variants was highly significant (p=0.00003).

FI was the most highly significant factor between patient groups with a good and poor outcome ( P =0.00003, independent groups t -test, t =−4.38, df 98).