“highly significant”

Compared to non-HDP individuals, subgroups 1–3 each had a large effect size for PAPPA2 (joint Cohen’s d = 1.05 [95% CI 0.91–1.19]), whereas subgroups 4–8 each had small effect sizes for PAPPA2 (joint Cohen’s d = 0.18 [95% CI 0.12–0.25]), a highly significant increase in effect size of 5.7-fold (95% CI 4.0x–9.3x, p < 2e−5) suggesting a strong placental involvement for subgroups 1–3.

In 1971, Pauling published a meta-analysis in which he showed that there was highly significant evidence from four placebo-controlled trials that vitamin C is beneficial against the common cold with p = 0.00002 ( 56 ), a conclusion that has since been corroborated in a large series of further randomized trials ( 57 , 58 ).

As a result, chromosomal differentiation between mtDNA subclades across both traits was highly significant (Fisher’s exact test, Chi-Squared > 26.46, d.f. = 4, p < 0.00002), but it was high and significant for A-chromosome number (F ST = 0.763, N = 82, p < 0.00001) and low and not significant for B-chromosome frequencies (F ST = 0.090, N = 41, p = 0.179).

We also observed a highly significant difference in allele frequency between the Benin and Yoruba samples (HapMap Project) for the SNP rs3130315 (p = 2 × 10 -5 ) and between the Mongolian and Han Chinese samples (HapMap project) for two SNPs: rs9562080 (p = 0.047) and rs4116821 (7.36 × 10 -11 ).

When the entire sample was evaluated together, the facial asymmetry scores of the scoliosis group were significantly higher than those of the non-scoliosis group, and this difference was statistically highly significant (U = 1848.5; p = 0.00002).

The log-rank test for a difference in the CIF for GFNA between recipient age <50 and ≥50 years was highly significant, yielding p = 0.00002.

We observed a highly significant positive correlation between MSI/hypermutation frequency and the total number of somatic mutations per cancer after integration by OncoMerge (R = 0.68 and p value = 2.0 × 10 −5 ).

For the U-87 MG glioblastoma cell line, on which the present study was focused and for which correspondingly more experiments were performed, the enhancement was statistically highly significant ( p = 2 × 10 −5 ).

The increase in predictive power is highly significant ( p < 2 × 10 −5 ; paired Wilcoxon test).

Importantly, we also observed a highly significant inverse correlation with the expression of AR (P = 0.00002) (Figure 1 A).

By 24 hours, the difference was highly significant ( P = 0.00002), with 30% and 40% of patients on nalbuphine experiencing no or mild pain compared with 15% and 25% of patients in the morphine group, respectively.

Age as a qualitative variable (calves/adults) was found to be highly significant in univariate analysis ( p significance or p -value = 2 × 10 −5 ).

As a result, a significant difference between the prisms with and without cyanobacteria was detected (Figure 2) for bending tensile strength (t = 2.9717; p = 0.0180) and a highly significant difference for compressive strength (t = 5.75; p = 0.00002).

Effect of seed treatments with bacterial endophytes on OSR yield, growth and disease incidence under commercial field conditions (Poříčí, Czech Republic) Except for a highly significant (P = 0.00002 and P = 0.00033, respectively) reduction of stress symptoms (red discolouration of leaf margins) by both IP and IG inocula in early spring (March 2017; Table 2 ) none of the seed treatments with bacterial endophytes affected growth, yield and diseases of OSR significantly under commercial field conditions.

Negr1 -WT mice demonstrated improvement in the time required to find the hidden platform (escape latency) over the first three training days and there was a highly significant improvement from day 1 to day 3 ( p = 0.00002).

Compared with the CC-Random group ( Appendix A:Supporting Information S2 ), The relative matched frequency (RF) of the BFE-mRNA sequence was more obvious in these two regions, and the difference in RF at the 3’end was highly significant ( t -test, p < 0.00002).

Again, a highly significant (p = 2 × 10 −5 ) overlap was observed in kidney cancer.

The difference between the cumulative growth in the number of PVCs in the control and riluzole groups was highly significant, at p<0.00002.

In contrast the log-SED index had a highly significant association with the MD values ( P = 0.00002).

This analysis indicates that the 33 genes identified in our study represent a highly significant level of overlap ( p < 0.00002).

The number of observed confirmations is highly significant ( P < 2 × 10 −5 , Z -score = 77.2), because no more than 16 matches (1%) were observed in 50,000 simulations that apply a transcription factor's annotations to its shuffled motifs ( Fig. 3D ).

The difference between stimuli remained highly significant ( F (1,43) = 23.69, p = 2·10 −5 , η 2 = 0.137, η p 2 = 0.355), in accordance with vestibular enhancement.

The bin spanning R 2 = 0.98–1.00 — centered on Rc—exhibits a highly significant dip test (p = 2.1 × 10 −5 ; GMM-BIC: two components), directly capturing the symmetry-breaking transition at the bifurcation point.

One SNP (GGaluGA348872), located at 1.87 Mb on GGZ, had highly significant association with IMF Br (p = 2.14 × 10 -5 ) and is located 122.3 Kb upstream of the kinesin heavy chain member 2A ( KIF2A ) gene.

A role for cis -regulatory elements in methylation fidelity was also demonstrated by highly significant (p<2.2×10 −5 ) enrichment of transcription factor binding sites in CGI probe loci showing heritably high (118 elements) and low (47 elements) methylation, and also in loci demonstrating stochastic hyper-(30 elements) and hypo-(31 elements) methylation.