“highly significant”

The meta-analytically computed, pooled relative, placebo/drug relapse rate was 1.90 (CI: 1.73–2.08), a highly significant decrease ( z -score = 13.3, p < 0.0001; Table 1 ).

Type × vertical position association Cross-tabulation analysis revealed a highly significant association between primary type and vertical position (χ2 = 33.574, df = 4, p < 0.0001).

This was highly significant ( p < 0.0001; Figure 3 c).

We found a highly significant correlation between chronological age and epigenetic age for both baseline (V1) and week 12 (V2) calculated using the Hannum (V1: p < 0.0001, R = 0.74; V2: p < 0.0001, R = 0.77; Fig. 2 A) and Horvath (V1: p < 0.0001, R = 0.69; V2: p < 0.0001, R = 0.70; Fig. 2 B) clocks.

The CaM scores showed a highly significant negative correlation with FVC (Pearson r -0.556; p <0.0001) ( Fig 2B ) and the DLco (Pearson r -670; p <0.0001) ( Fig 2C ).

Test Treatment C demonstrated highly significant increases of 17.48 ± 1.79 or 34.85% (p < 0.0001) at day 30 when compared to the baseline and 22.42 ± 9.1 or 73.67% (p < 0.0001) at day 90.

herba-alba demonstrated a highly significant repellent effect against S. oryzae compared to the tablet-like formulation (F = 605.9; df = 1; p < 0.0001), with repellency increasing progressively over time (F = 14.48; df = 5; p = 0.0019).

Those showing highly significant difference ( p ≤ 0.0001) were analysed with the ROC curves to determine the best differentiating values.

Two-way ANOVA shows highly significant differences [F(1,24)=31.5, p<0.0001] between HAT genes expression in controls and embryos injected with well described Dystrophin morpholino cocktail (also see Materials and methods, S1 Fig A ).

With a highly significant effect of enzyme concentration ( p < 0.0001), regardless of enzyme type ( p > 0.05), the fibrous appearance of the pork loin samples recorded higher mean scores, increasing from 5.67 ± 0.19 in the control sample to a range of 6.77–6.97 in all enzyme-treated samples.

Moreover, a highly significant difference in ATF6 expression was observed between diabetic females and males in this region ( p < 0.0001) (Fig. 4 c).

Notably, when comparing RIG_LDH-GA CM to RIG CM, the reduction in OC number was highly significant ( p < 0.0001) at all doses except the lowest one.

The difference between the subjects here and subjects in the previous study [ 5 ] was highly significant (p < 0.0001), for both the 5 point and a 10-point PCL score declines.

Studies of lesions of patients with borderline leprosy have revealed strong correlations between TGF-β and NGF, and TGF-β and NGF-R ( r = 0.8722 and r = 0.7257, respectively), with highly significant p -values for the two correlations ( p < 0.0001 and p = 0.0015, respectively) ( 48 , 49 ).

3 A shows that the IpGTT produced a highly significant time-dependent increase in blood glucose concentrations in both WT (F = 23.85, p < 0.0001) and Tau-VLW (F = 14.16, p < 0.0001) mice.

By day 30, the DG exhibited characteristic features of granule cell dispersion (GCD), with loosening of the granule cell layer, blurring of the boundary between the granule cell layer and molecular layer, and expansion of granule cell distribution ( Figure 1 C), in line with previous observations in experimental and human TLE [ 46 , 47 ].Quantitative evaluation of NeuN immunofluorescence demonstrated a highly significant, progressive increase across the evaluated longitudinal time points from day 1 to day 30 post-modeling (One-way ANOVA, F (4, 10) = 2495.0, p < 0.0001).

However, packaging treatment exerted a highly significant main effect on all color attributes ( p < 0.0001), highlighting the predominant influence of packaging type on strawberry visual quality during storage.

The model was determined to be highly significant ( p < 0.0001), while the lack of fit term was not significant, further corroborating the adequacy of the model.

Significance analysis of regression coefficients reveals the linear term A (trehalose) is highly significant ( p < 0.0001), B (lactose) is significant ( p < 0.05), and C (skim milk powder) is highly significant ( p < 0.01).

There was a clear difference in the soma areas of the NK1r cells that were retrogradely labelled with CTb (range, 116-1084 μm 2 ; median, 228 μm 2 ) and those that were not (range, 52-625 μm 2 ; median, 101 μm 2 ), and this was highly significant ( P < 0.0001; Mann–Whitney U test).

colemani in Spring Cucumbers A repeated-measures ANOVA revealed that the main effect of DACT was highly significant ( F = 219.78, df = 3, 1347, p < 0.0001), as was the interaction between treatment and DACT ( F = 53.97, df = 6, 1344, p < 0.0001), indicating significant temporal variation and treatment effects over time.

Statistical implication was set at the highly significant level of P <0.0001.

The overall model was highly significant ( p < 0.0001), confirming that the selected factors collectively have a strong effect on DPPH activity.

A highly significant decrease in the VAS digestive symptom score was observed in the Marsh stage 1 group (pre = 47.5 vs . post = 33.2, P <0.0001), whereas the change in the Marsh stage 0 group (pre = 45.9 vs . post = 44.0) was not significant.

The difference between farm B (highest reduction) and farms D and F (lowest reductions) was highly significant ( p < 0.0001).