Barely Significant
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“highly significant”

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highly significantp < 0.00010.0× alphaqualifiedgold
The model also showed significant correlations with clinical markers, including faecal calprotectin ( r s = 0.50), C-reactive protein (CRP; r s = 0.45) and Physician Global Assessment ( r s = 0.45), all of which were highly significant ( p < 0.0001), supporting the clinical validity of UC-SCALE. 23 Aside of CNNs, other computational methods have been employed to detect mucosal inflammation.
highly significantp < 0.00010.0× alphaqualifiedgold
Echocardiography The difference in Group I and Group II was highly significant in terms of both the baseline GLS (-13.37 ± 2.21 vs -19.11 ± 3.4; p < 0.0001) and GLS at 1-year follow-up (-11.23 ± 2.19 vs -13.47 ± 1.84; p < 0.0001).
highly significantP < 0.00010.0× alphaqualifiedgold
This is supported by their highly significant levels observed in both A549 cells ( P adjust < 0.0001 for both FAM83A and GPR37 genes in Table 4 ) and LUAD patients ( P < 0.0001 for both FAM83A and GPR37 genes in Fig. 5 a).
highly significantp < 0.00010.0× alphaqualifiedgold
The Egger’s test result was highly significant (t = 6.60, p < 0.0001), indicating potential asymmetry and suggesting the likelihood of publication bias ( Supplementary File S26 ). - Similarly, in the OS multivariate analysis, the funnel plot showed some studies lying outside the triangular area, consistent with significant heterogeneity.
highly significantp < 0.00010.0× alphaqualifiedgold
The robustness of the model was further supported by multivariate test statistics, including Pillai’s trace, Hotelling–Lawley trace, Roy’s greatest root, and Wilks’ Lambda, all of which were highly significant (p < 0.0001), confirming the presence of a statistically meaningful association between the two variable sets.
highly significantp < 0.00010.0× alphaqualifiedgold
6.65 X 2 X 3 − 35.03 X 1 2 − 47.97 X 2 2 − 29.11 X 3 2 Y 2 (TFC) = 58.85 + 5.13 X 1 + 0.27 X 2 − 1.13 X 3 − 0.43 X 1 X 2 + 0.80 X 1 X 3 − 0.39 X 2 X 3 − 4.51 X 1 2 − 2.53 X 2 2 − 1.71 X 3 2 The results of the analysis of variance in Table 2 suggest that the fitted models for TPC and TFC were both highly significant ( p < 0.0001), while the lack of fit was not significant ( p -values: 0.2161 and 0.3343, respectively), indicating a good fitness for the models.