“highly significant”

Although the difference was small, it was highly significant ( P < 0.0001) and consistent with previously published results [ 15 ].

4 In 30 of 34 reviewed studies, persistent microscopic inadequate (R1) or macroscopic inadequate (R2) surgical margins were highly significant for LR compared with negative margins ( p = 0.0001), depicting the relevance of margin status on the outcome of BCT.

However, over time, the exercise speed of bves KO zebrafish significantly decreased, showing a highly significant difference compared to WT zebrafish ( Figure 3 D, p < 0.0001).

Results Highly significant clinical improvements were observed according to NDI and VAS (P < .0001 (arm); P < .001 (neck); P = .002 (head)) at all time points.

Unlike other developed models, the highly significant HHV model ( P < 0.0001) for the solvolysis process only contained the independent terms.

Our model results showed a highly significant interaction (χ 2 = 94.3, P < .0001) [ 27 ], confirming a difference in patterns of deferral by CD4 count and patient type.

Longitudinal tumor growth data, analyzed using a linear mixed-effects model with restricted maximum likelihood, revealed highly significant effects for both the time × group interaction [ p < 0.0001, F(5.514, 32.81) = 11.36] and the group main effect [ p < 0.0001, F(5, 119) = 41.56] ( Figure 2e ).

After applying FDR correction, the correlation between the probability of occurrence of the different PL states and OP revealed a highly significant positive correlation between PL state 3 and OP (r = 0.8632, p < 0.0001), which supports this hypothesis.

These differences were highly significant for both wild type and Atxn2 ko mice (ANOVA with repeated measure, P<0.0001).

The mean difference between the two groups was 202 g, which a paired t -test confirmed to be statistically highly significant ( p < 0.0001) ( Figure 3 ).

While the mean DR of [ 18 F]AlF-OC was not high enough to be significantly superior to [ 68 Ga]Ga-DOTATATE, it was highly significant for non-inferiority testing ( p = 0.0001).

While the baseline value was consistently a highly significant factor ( p < 0.0001), the interaction between time and group remained non-significant for all outcomes ( p > 0.3).

Thermal Detection Thresholds ANCOVA with age as a covariate (partialing out the highly significant age-related effects) revealed a highly significant effect of group (F 2,113 = 30.04, p<<0.0001), body side (ipsilateral vs. contralateral: F 1,113 = 12.39, p<0.001) and group x side interaction (F 2,113 = 4.65, p<0.05) for the cold detection threshold (CDT).

The p -values of the linear regression analysis were highly significant in all three studies (p < 0.0001).

The above results were subsequently analyzed using Design-Expert software, yielding the following second-order polynomial regression equation: Y = −28.06537 + 1.35037A + 1.55369B + 0.066144C − 0.007187AB + 0.00075AC + 0.000141BC − 0.169750A 2 − 0.028281B 2 − 0.000218C 2 ANOVA-based statistical validation demonstrated that the model was highly significant (F = 210.21, p < 0.0001) and exhibited strong predictive capability, with an adjusted R 2 of 0.9916, indicating good model fit.

Retinal sensitivity showed highly significant improvements in the fovea ( p < 0.0001), inferior quadrant ( p < 0.0001), nasal quadrant ( p < 0.0001), and temporal quadrant ( p = 0.0003), while the superior quadrant failed to sustain statistically significant improvement at 1 month ( p = 0.1216).

Although differences in peak glucose time were observed (30 min for capillary blood and 45 min for CGM), the correlations between capillary and CGM values at both 30 and 45 min were strong and highly significant ( r 2 = 0.728 and r 2 = 0.806, p < 0.0001, respectively).

Morphometric analysis revealed a highly significant reduction in cell size in the spt7Δ mutant compared to WT ( p < 0.0001, Figure 6 B). 3.4.

These overlaps represented highly significant enrichments (Fisher’s exact test, P < 0.0001; odds ratios = 2.4 for hypertension and 3.8 for CKD), highlighting that the transcriptional shifts seen in our rat model overlap strongly with known human hypertension and CKD risk loci-associated genes.

Specifically, post-hoc comparisons revealed that the difference found when analysing samples at 24 and 48 hpi was highly significant (P<0.0001 for both N1 and N2 gene sequences, Fig.

The V/O relationship was highly significant at all ages ( P <0.0001, linear regression model), but neither the gradient ( P = 0.0961) nor the intercept ( P = 0.649) changed with age.

In this analysis, group differences in subjective pain scores were highly significant before controlling for the effect of anterior cingulate cortex activation ( F = 38.0, P <0.0001); a finding that was reversed ( F = 1.8, P = 0.195) when removing (regressing out) this effect.

A highly significant relationship ( p <0.0001) was observed, with a plasma concentration of 355 ng/ml identified as that required for intracellular mycobacteriostasis.

The mean numbers of SA and SU residues per molecule of FSH and LH in serum showed four different patterns during the cycle, all with highly significant ( P < 0.0001) differences between levels at different phases of the cycle.

A two-way ANOVA detected a highly significant effect of light on E PAR (F1,74= 132.20, p < 0.0001) and a significant species vs. light interaction (F3,74 = 9.71, p < 0.0001), while for the main effect of species no significant differences were detected ( p = 0.627).