“highly significant”

Jarvinen and colleagues [ 84 ] evaluated topoIIα expression immunohistochemically in 230 breast cancer specimens and found a highly significant correlation with tumour proliferation rate measured by SPF (p < 0.0001).

As expected, we found a highly significant trend for increased concentrations of leptin with increasing levels of overweight or obesity ( P < 0.0001).

23 % (109/467) of our DEGs were shared, this overlap being highly significant (hypergeometric test p -value < 0.0001).

*, P < 0.05 was considered statistically significant, **, P < 0.01 was considered highly significant, and ****, P < 0.0001 was considered extremely significant.

We found a highly significant increase in synaptic abnormalities in oocytes from BPA-exposed females (16.0% versus 52.0% of cells in placebo and BPA, respectively; χ 2 = 134.8; p < 0.0001; Figure 1 A), largely attributable to increases in two categories of abnormality: “incomplete synapsis,” in which a single chromosome pair remained unsynapsed in an otherwise normal pachytene cell (0.5% in placebo versus 11.0% in BPA; Figure 1 C), and cells with end-to-end associations between nonhomologous SCs (7.7% in placebo versus 25.6% in BPA; Figure 1 D).

This difference is highly significant ( P < 0.0001), demonstrating that the X chromosome is enriched for female-biased single transcript genes.

All correlation coefficients were highly significant (p < 0.0001).

Such models were highly significant (p < 0.0001) for determining TPC, TFC, ABTS, OH, and DPPH.

The 4w-11 line was characterized by three highly significant I-kappaB/NF-kappaB pathway-related functions (p < 0.0001) (Table 10 ).

Thus, unpaired t -test reported a highly significant difference between the surface characteristics of control arch-wires and the test arch-wires ( P = 0.0001) [ Table 1 and Figure 4 ].

The primary analysis showed a highly significant treatment effect overall across all four time points (−17.4 mm; 95% confidence interval: −22.3 to −12.5 mm; p < 0.0001).

Moreover, the correlations between the concentrations of free and total (free plus conjugated) species of methyl and n- propyl parabens were highly significant ( p < 0.0001 and p = 0.0096, respectively; Figure 2 ).

There are 502 genes in common between the two sets (5,178 from 28 earlier studies and the 1,201 reported here); this degree of overlap is highly significant ( p < 0.0001), yet indicates that our approach yielded a large number of genes (699) ( Table S7 ) not previously known to be UV responsive.

An analysis of variance, with sense of closeness as the dependent variable and all nine variables as factors, was highly significant (F 11,17 = 25.89, p < 0.0001).

Quantitation of the dispersal of the TGN in SS-RARP2 transfected cells confirmed that the TGN disruption was highly significant (p < .0001) when compared to cells transfected with Iowa-RARP2-GFP, SS-RARP2-C109A-GFP, or EGFP ( S6B Fig ).

Body conformation indices of pelvic index, body index, transversal pelvic index and weight were highly significant ( p < 0.0001) among the studied districts.

The difference in freeze-thaw mortality rates between ancestral and evolved rates is highly significant (two-tailed t-test with unequal variances, p < 0.0001).

The linear correlation between estimated and measured glycemia was highly significant (r = 0.68; p = 0.0001) in the trained group and not significant in controls (r = -0.12; p = 0.32).

The correlation between vascularization and the Breslow thickness was highly significant ( p <0.0001).

Univariate F test analysis showed that differences between the two groups, at each half-cycle, were all highly significant (p < 0.0001 for the first 5 half-cycles; p < 0.01 for the last half-cycle).

However, 55 of 60 farms with a mains supply to the farmhouse also had a mains water supply for their cattle and there is highly significant correlation between the farmhouse and cattle water sources (χ 2 = 44.5, df = 1, p < 0.0001).

The interaction between fitted environmental mean and treatments was highly significant ( F = 3.17; P < 0.0001; Table A7 Supplementary material), showing that the slopes are different between treatments.

Publication bias and sensitivity analysis Initially, the plausible sources of publication bias were visualized through a funnel plot with Egger test, where the publication bias was found to be highly significant ( P < .0001) (Fig. 5 ).

The seminal fluid concentrations of Pb (SfPb) and Cd (SfCd) were measured in 118 of the 149 subjects, and a highly significant (p < 0.0001) correlation was found between BPb and SfPb levels (r = 0.571) and between BCd and SfCd levels (r = 0.490).

A highly significant correlation was found between maximal strength in vertebral bodies and BMD measured either by DXA (r = 0.86) or pQCT (r = 0.85) (both p < 0.0001).