“highly significant”

A Kruskal-Wallis test indicated that the difference in NPRA expression among the seven diagnostic groups was highly significant (p < 0.0001).

At the local scale, analysis revealed a highly significant isolation-by-distance pattern when all areas were tested jointly (r 2 = 0.069; Mantel test p < 0.0001; Figure 5 ).

As expected, highly significant differences were observed between patients and controls in global cognitive status based on the PD-CRS [t(65) = 6.5; p < 0.0001], motor symptom severity based on the UHDRS-TMS [t(65) = 10.9; p < 0.0001], functional status based on the TFC [t(65) = 7.2; p < 0.0001], as well as on NfL plasma levels [t(65) = 10.73; p < 0.0001], all with large effect sizes (d > 0.8). 3.1 Verbal episodic memory performance The three-way mixed-effects ANOVA with recall type (free vs. cued) and time (immediate vs. delayed) as within-subjects factors, and group (HD vs.

albopictus ), with statistical analysis (permutation test in MorphoJ) indicating highly significant differences between most of these species ( p < 0.0001; p < 0.01; and p < 0.05; S2 Table ).

At the Central Sahara scale, a highly significant IBD pattern (both for Ritland and Loiselle kinship coefficients, p -value < 10 −4 ) was observed (R 2 ranging from 0.066 to 0.080; Figure S4 ).

We found a highly significant and marked response of control neurons to 100 nM orexin A, while the Ox1R knockout neurons did not respond (control: p<0.0001, n=71; Ox1R ΔDAT : p=0.5, n=86; one sample t-test for each group) ( Figure 1L ).

A consistent and highly significant reduction of ALP levels was observed following GFT505 treatment in both studies (S1 −16.4% [−∞ to −12.4]; S2 −24.5% [−∞ to −19.1], all P < 0.0001) ( Tables 2 and 3 and Fig. 1 D ).

However, increasing arsenate concentration had a highly significant effect on normalized growth rate ( p < 0.0001; Figure 3 A).

Altered K/Na, Ca/Na and Mg/Na Concentration Ratios Are Strong Indicators of Na-Stress Exposure The ANOVA summary for concentration ratios of K, Ca or Mg with Na in examined test crop tissues showed a highly significant ( p < 0.0001) impact of NaCl salinity, whereas the soil Cd contamination as well as the CdxNaCl interaction were not significant ( Table S3 ).

At 1 mm apical to TP, group differences were highly significant ( p < 0.0001), with no time ( p = 0.93) or interaction effects ( p = 0.70).

= 1, 3; χ 2 = 12.50; p = 0.0058) and a highly significant generation × treatment interaction (GLMM; n = 6; d.f. = 1, 3; χ 2 = 31.75; p < 0.0001), suggesting that the effect of IMI on larval mortality varied across generations ( Figure 6 ).

All associations were highly significant in both sexes, P <0.0001.

The correlations between ALC and a CD4 cell count, and between TLC and a CD4 cell count were highly significant (spearman correlation coefficients of r=0.5604, P <0.0001 and 0.3497, P <0.001 respectively).

Two-way ANOVA of the normalized transcript counts acquired from microglia incubated for 24 h with vehicle ( n = 3), UNMOD myelin ( n = 3), or CIT myelin ( n = 3) revealed a highly significant difference between groups ( F (27,368, 82,110) = 1.775, P < 0.0001).

Results There is a highly significant decrease ( P = 0.0001) in the serum levels of IgG, IgG/IgM ratio, and serum albumin in the patient groups compared with the control group as shown in Table 1 .

These three trend indicators were still highly significant ( p < .0001) when added jointly to the existing model using the following transformations: X 3 + X 3 *log(X) for the absolute change in the risk score from the previous day; X 0.5 + X 0.5 *log(X) for the absolute change in the risk score from the start of the trend; and X -2 + X -2 *log(X) for the number of consecutive days with a trend in the risk score (we first shifted all original values up by the minimum observed value to ensure the values were greater than zero).

Results AMH and OSI show a highly significant negative correlation (r = -0.67; p = 0.0001) that is stronger than the one between AMH and the total number of retrieved oocytes and than the one between AMH and the total FSH dose.

Regarding schistosomiasis, cysteine peptidases, such as papain, Schistosoma mansoni cathepsin B1 (SmCB1) and cathepsin L3 (SmCL3) and Fasciola hepatica cathepsin L1 (FhCL1) do not induce allergic reactions in mice or hamsters and were shown instead to elicit reproducible and highly significant ( P < 0.0001) reduction of 50–65% in challenge S. mansoni and Schistosoma haematobium infection, via generation of polarized (papain, SmCL3, FhCL)- or predominant (SmCB1) type 2 responses involving release of TSLP, IL-4, IL-5, IL-13 and generation of IgG1 antibodies [24] , [25] , [26] , [27] , [28] .

This difference was highly significant (p <0.0001).

The most substantial impact on elastase inhibition, as indicated by the IC 50 value, was attributed to temperature (B), which exhibited a regression coefficient of 12.87 and a highly significant p -value ( p < 0.0001).

This decrease was concomitant with a highly significant increase in the Cho/Cr ratio for the EAE (0.28 ± 0.04) compared with the healthy mice (0.18 ± 0.03, p < 0.0001).

This increase was highly significant (p<0.0001).

The difference in the occurrence of other events in amplified isolates compared with zero in the 240 stressed control samples is highly significant (p = 0.0001; Fisher's exact test).

Similarly, at 3, 4, 5 and 6 h postoperatively, the incidence and severity of CRBD in group B was much lower than in Group A, which was statistically highly significant with a P value < 0.0001 [ Table 2 ].

In terms of soil organic matter content, Wutai County had a significantly higher level (35.25 ± 4.20) compared to Pingshun County (26.65 ± 2.14), and this difference was statistically highly significant ( P < 0.0001).