“highly significant”

In total, 2 of 15 transient lineages carry longitudinally persistent and induced prophages, while 9 of 9 persistent lineages carry such prophages, and a Fisher’s exact test indicates a highly significant association between inducible phage and persistence of lineage ( P < .0001).

After one and 2 months treatment, the mean levels of perceived pain intensity were 4.39 and 3.59, respectively, and the mean changes from baseline were both highly significant ( P < 0.0001; Table 4 ).

To statistically assess the overlap between the two gene sets, we performed a Fisher’s Exact test, which demonstrated a highly significant concordance (P < 0.0001, two-sided), indicating that the shared transcriptional response is unlikely to occur by chance (Supplementary Table S1 ).

In contrast, a highly significant difference ( p < 0.0001) was found between groups 1 and 3 as well as between groups 2 and 3 (see Fig. 3 ).

Including genotype in the mixed model had highly significant effects on period ( χ 2 (1 d.f.) = 455.57, p < .0001) and RAE ( χ 2 (1) = 65.97, p < .0001).

All models were highly significant ( p < 0.0001).

The most parsimonious multivariate model is highly significant ( P = 10 –4 ), suggesting that COVID-19 DS4 ( P = 3 × 10 –8 ), presence of DKA/HHS ( P = 0.021), and development of AKI ( P = 0.037) are all independently correlated with death (Fig. 3 ).

For salivary cortisol, male students exhibited a highly significant increase ( p < 0.0001) with a mean difference of 2.602 ng/mL between baseline and follow‐up samples, while female students also showed a significant increase ( p < 0.0001) with a mean difference of 2.950 ng/mL.

The generated Moran's I values (Table 2 ) are highly significant ( p value < 0.0001) and indicate a quite strong degree of positive spatial autocorrelation; regions with similar rates of COVID-19 deaths tend to be located next to each other (i.e. they form spatial clusters).

The values of Shannon and Simpson’s diversity indices were 1.116 and 0.602 for Greenlon’s sample respectively versus 0.613 and 0.335 in the presents sample (Table 2 ), a difference that was highly significant in both cases ( p < 0.0001).

A highly significant knockdown efficiency of murT was found with sgRNA1- murT comparing with WT ATc (53.5-fold; P < 0.0001), PLJR962 ATc (44.6-fold; P < 0.0001) or the respective uninduced mutant (57-fold; P < 0.0001).

A post-hoc analysis revealed a moderate, but highly significant negative correlation between time from disease onset to diagnosis and disease progression rate (Spearman r = − 0.4798; p < 0.0001).

Statistically, two-way ANOVA showed a highly significant interaction of “group X cell cycle phase” between shNXN and scrNXN for G1, G2/M (both increased in shNXN) and >G2 (reduced in shNXN) ( p < 0.0001).

The differences between the diabetes groups and the control group were highly significant with P < 0.0001.

As shown in Additional file 1 : Figure S1, the correlation of eGDR calculated using this formula with glucose disposal rate (GDR) measured with euglycaemic-hyperinsulinemic clamp in 140 T2D patients was highly significant ( r = 0.624; p < 0.0001); moreover, it was higher than that of Homeostasis Model Assessment – Insulin resistance (HOMA-IR) in the 85 patients with calculable values ( r = 0.441; p < 0.0001) and similar to that reported in the validation study in T1D individuals [ 25 ].

MYOCD x CSPG4 correlations were highly significant across the brain regions examined in this analysis (P < 0.0001 throughout).

Correlation analysis There were highly significant negative correlations between anxiety and depression scores and LAC ReHo values in the DON group ( r = -0.9336, P < 0.0001 and r = -0.8453, P < 0.0001, respectively; Figure 5 ).

Eleven of these were within-serogroup switches, representing a highly significant ( p < 0.0001) enrichment based on the observed serotype distribution.

Analysis of variance (ANOVA) demonstrated excellent model fit for the crude enzyme system, with a determination coefficient (R 2 ) of 0.9878, adjusted R 2 of 0.9721, and a highly significant model F-value of 62.93 ( p < 0.0001), as detailed in Table S2 .

The analysis revealed highly significant differences for all three parameters ( p < 0.0001), confirming that the type of plant extract used in FeNP synthesis had a substantial impact on catalytic performance ( Table 6 ).

The two main effects (primer and treatment) and their interaction were all highly significant (P < 0.0001).

When comparing the medians (interquartile ranges) of the 2 GA-T trials performed by the participants, no significant difference was noted, although the time to complete the second trial was shorter [365 (260-545) s vs 360 (250-540) s, P=0.81]; highly significant intraobserver agreement (P<0.0001) was observed between the measurements of the 2 GA-T trials (ICC=0.97 and 95%CI: 0.96-0.99).

2 A ) and a tight linear relationship ( R 2 = 0.9430) with a highly significant correlation ( ρ = 0.9711, p < 0.0001) of the serum antibody inhibition capacity to both RBD variants ( Fig. 2 B ).

We log-transformed circulating DAAM2 mRNA expression, demonstrating a highly significant increase (p < 0.0001) in circulating DAAM2 mRNA in pregnancies complicated by preterm fetal growth restriction (Fig. 1 a) compared to gestation-matched controls.

The point-by-point comparison of Carto-derived and OpenEP-derived interpolated local activation time maps revealed a highly significant correlation between these two metrics ( R 2 = 0.8892, P < 0.0001) ( Figure 6B ).