“highly significant”

A parallel medium-challenge assay, performed with blood meals containing 0.1 to 0.2% gametocytemia, resulted in highly significant reduced oocyst and sporozoite prevalence ( P < 0.0001 and P = 0.0002, respectively).

There was a highly significant difference between the cerebral malaria and meningitis groups ( Figure 1 ) ( P < 0.0001).

Remarkably, MV2C, the histotype of which is virtually indistinguishable from that of MM2C, showed a large predominance of the 129 M allotype, with resPrP D -129 M accounting for 83 ± 7% of total resPrP D , a difference between populations of resPrP D -129 M and -129 V statistically highly significant ( p < 0.0001).

Similarly, the correlation of the infection neutralization capacity of Omicron BA.1 and NAb was highly significant ( p < 0.0001) and moderately (rho = 0.44) positive.

There was a highly significant change in ACTH levels observed in the M, ELb, Esch, and ELbEsch groups ( p < 0.0001), and a pronounced difference was seen in the EThy group ( p < 0.001), as shown in Figure 3 c.

PERMANOVA confirmed a highly significant effect of time (weeks) on microbial community structure (F = 60.664; P = 0.0001), whereas treatment had no significant standalone effect (F = 0.8889; P = 0.4175; Fig. 6 ).

A 2 × 2 contingency analysis comparing the groups was highly significant (Chi-square = 25.75, df = 1, p < .0001, Phi = .30).

Statistical analysis indicated highly significant differences ( p < 0.0001) between N3 and N3-O formulations, confirming that sonication significantly enhances the antimicrobial activity of Ni2CoS4 HSs across both Gram-positive and Gram-negative pathogens.

As a cross-check, calculated (via DIC and TA) and directly measured pH values were compared and showed a highly significant correlation and no outliers (pH (total scale) = 0.9176 pH (NBS) +0.5453; r 2 = 0.99; p<0.0001).

In the analysis of variation among the frequencies in each ear alone, we noticed that it was highly significant (p<0.0001-t Student test) in all the frequencies for both the right and the left ears.

In sharp contrast to the lack of discernible directional preference in the horizontal chambers, we found that N2 dauer larvae demonstrated an enhanced and highly significant preference for upward migration in the vertical chambers under these conditions (average vertical location = +1.63, n = 4,358 worms, 12 trials; p < 0.0001, all comparisons) ( Figure 2 A and 2B).

Overall, the test for subgroup differences was highly significant ( p < 0.0001), confirming that the type of intervention substantially influences outcomes.

All models were highly significant ( P < 0.0001).

Analysis of FSH and INB levels in the groups we defined, revealed highly significant differences among the 4 groups for both males ( P < 0.0001, ANOVA), and females ( P < 0.0001 and P < 0.001 for FSH and INB respectively) (Figure 1 ), as expected for the study design.

In the adjusted model, frailty was the only variable with an aOR of 3.90 (2.75–5.55), which was highly significant, p < 0.0001.

Although the differences between the two sample groups are small in values for the normalized counts, the differences are statistically highly significant ( P < 0.0001).

However, patients with a high FRET efficiency (Fig 4 B) had considerably better survival (highly significant P < .0001) in first-line treatments compared with low FRET patients (median 50% survival still undefined after 50 months for high FRET v 11 months for low FRET patients).

4 D). Protein and mRNA expression ratios showed a highly significant but weak positive correlation (Pearson's r = 0.405, Spearman's r = 0.378, both P < 0.0001) based on 2456 mRNA–protein pairs (Fig. 4 E).

We observed a highly significant inverse correlation between these parameters with both Pearson’s and Spearman’s tests (r = −0.617 and r = −0.611, respectively; P <0.0001) (Figure 2 ).

The amount of activated microglia (RPT) was decreased in a highly significant manner, from 57.47% to 32.50% (**** P ≤ .0001), after 24-hour incubation at a concentration of 25 μg/mL TPM and to 43.17% (n = 18; ** P < .01) at a concentration of 50 μg/mL TPM.

Results were considered significant when P <0.05 and highly significant when P < 0.0001.

In the HKT group, the following improvements were observed: PH domain: p = 0.0006 (highly significant, Figure 10 ); Pain domain: p < 0.0001 (extremely significant, Figure 11 ); FA domain: p = 0.0428 ( Figure 12 ).

Using RT–qPCR primers that distinguish wild type (WT) and KCNQ2 ∆E5 , we found a highly significant difference, with KCNQ2 ∆E5 detected exclusively in patient samples ( P < 0.0001 adjusting for age, sex and RNA integrity number (RIN); Supplementary Table 2 ), while the levels of WT KCNQ2 transcript were not different ( P = 0.9947 adjusting for age, sex and RIN; Supplementary Table 2 ) (Fig. 2f,g ).

This difference in the pattern of discordant classification in the Joslin and FinnDiane cohorts was highly significant ( P < 0.0001).

When analyzed as a mean of all GLU injections at the same dose, the oxygen increase was highly significant ( F (12,240) = 4.13 and F (12,900) = 5.33 for slow- and rapid time resolutions; p < 0.0001), it appeared with ~40-s latency after injection onset, and peaked 30–40 s after injection offset.