“highly significant”

Differences were highly significant in the chi-square test (P<0.0001).

Despite the small sample sizes, these combined SNV–CNV subsets demonstrated a highly significant difference in PFS ( p < 0.0001, Fig. 3 ).

These group differences were highly significant ( P < 0.0001).

Kindling also had strong heritability and differences were highly significant ( P < 0.0001) between strains ( Table 1 ).

As shown in Table 4 , all three predictors (entropy, density-TC, density-TN) are highly significant ( p <0.0001, after alpha correction because of multi-comparisons) when modeling the concreteness of a noun.

( 1995 ), where the correlation between sCA and dCA was highly significant ( r = 0.93, P < 0.0001).

There was a highly significant change in ACTH levels observed in the M, ELb, Esch, and ELbEsch groups ( p < 0.0001), and a pronounced difference was seen in the EThy group ( p < 0.001), as shown in Figure 3 c.

The ANOVA results suggested that the model was highly significant ( p < 0.0001).

A one-way ANOVA with the between-subject factor groups (CG, LG, IG, MG) revealed a highly significant effect, F (3, 115) = 30.68, p < .0001, η p 2 = .45.

The differential effect of aza in 4T1 Hif1b -KO versus 4T1 Hif1b -scr grafts was also highly significant in an interaction analysis ( P < 0.0001).

The Kaplan–Meier curve, however, does show a highly significant trend of loss-of-barrier function at higher concentration ( P < 0.0001 for both curve difference and trend significance, derived from log-rank tests) (Fig. 4i ).

Highly significant decreases in an age-dependent manner were observed in the concentrations of T3 and T4 ( p = 0.0001, both). 3.4.

At higher concentrations (12.5–50 μg/mL), the extract exhibited pronounced inhibitory activity, with highly significant reductions in biofilm biomass compared to the control group (*** p < 0.0001).

Statistical analysis using the Mann-Whitney U test confirmed this difference as highly significant ( p < 0.0001).

Accordingly, groups diverged following delivery; day of delivery was a highly significant covariate for the PORCH score (p<0·0001), but not for the SOFA score (p=0·09).

A Kruskal–Wallis rank sum test indicated a highly significant effect of category on daily movement distance (χ2 = 235.91, df = 2, p < 0.0001).

Notably, PBA administration produced a robust and highly significant reduction in seizure events in Slc6a1 +/A288V mice (** p < 0.0001) (Figure 8G ), mirroring the therapeutic efficacy observed in the Slc6a1 +/S295L model. 4 Discussion 4.1 SLC6A1 Variants Cause Loss of Function via ER Retention and Protein Trafficking Deficits SLC6A1 variants lead to profound GABA transporter dysfunction, disrupting inhibitory neurotransmission through a combination of impaired trafficking, altered protein folding, and reduced transporter activity.

† ANOVA results indicated that the model was highly significant, as the F value for the model was 17.58 ( p < 0.0001).

Considering, within-group comparisons, it was observed all experimental groups showed a highly significant difference across the specified time intervals i.e. 6,12 and 24th week ( p = 0.0001) indicating effective intervention.

These differences between habitat types were highly significant (H 5df = 27.91, p < 0.0001). 3.3.

The pattern of trait correlations among pigeons is highly significant when adjusted for repeatability ( r m >1 between rock dove and domestic (p<0.0001); r m =0.798 for the feral-domestic comparison (p<0.0001)) ( Supplementary Tab. 3 ).

CBL was found to cause a highly significant ( P < 0.0001) improvement in the students’ higher levels of cognition, whereas the lower orders of cognition remained unaffected ( P = 0.2048).

Chi-squared tests confirmed that these differences were highly significant in all three years (p < 0.0001).

The smoking status of the patients was available for 54% of patients, and a highly significant correlation in ADA levels was seen between ever smokers ( n = 84) and never smokers ( n = 63) ( p -value = 0.0001) ( Figure 12 ), a pattern that could also be noted over time ( Figure S14 ).

For the remaining data, we observed a highly significant effect of interaural correlation on ITD thresholds ( F (1,19) = 30.25, P < 0.0001).