“highly significant”

The enrichment for Cys-proximal N-linked glycosylation at the bases of the hyper-variable loops is highly significant (6/8 vs 0/16, p = 0.0002).

All the correlations were highly significant ( p = 0.0002, p < 0.0001, and p < 0.0001, respectively).

The Ctn reference ranges determined in this way for patients with nodular thyroid findings (90% confidence intervals) were <3.0 to 9.1 pg/mL for women and <3.0 to 14.1 pg/mL for men, i.e., very similar to the reference ranges specified by the manufacturer and with a highly significant sex difference ( p < 0.0002).

The difference in visual grading was also statistically highly significant for the three groups in post stress ( p = 0.0002), and a similar difference was noted at rest ( p = 0.004) ( Table 4 ).

Analyzing the data by geographic region, we see that the results are highly significant for America–Asia–Australasia (χ 2 = 12.22, P = 0.0002; Fisher's P = 0.0003) and Africa–Asia–Australasia (χ 2 = 9.71, P = 0.0009; Fisher's P = 0.0021), and still significant although not as highly so if one only considers Asia–Australasia (χ 2 = 3.178, P = 0.0373; Fisher's P = 0.1558).

A highly significant association was observed between IDH 1 status with respect to OG (p = 0.0002) and astrocytoma (p = 0.005).

However, a highly significant group-by-sex interaction was detected for both genes ( p = 0.00020–0.00080).

The differences between the populations are highly significant for both Cmax values, as determined by 3-group permutation ANOVA (p < 0.0002 for both) and pairwise Wilcoxon test for sparse vs dense (p = 2e-18 and p = 9e-14 for Cmax = 90 nM and 900 nM, respectively).

One is that advanced stages (RAEB and RAEB-t) had a highly significant association with the frequency of abnormal karyotypes ( P < 0,0002), evolution of disease ( P < 0,0001), and mortality ( P < 0,0005).

The results shown in Figure 3 , demonstrate a highly significant improvement in the survival time in Aldoxo-treated mice as compared with control or Doxo-treated mice ( P = 0.0002 for each comparison).

Although observing two siRNA sharing a hexamer seed sequence is not significant at the 5% level, observing two or more such seeds is significant (P = 0.013), while finding four siRNAs sharing a seed sequence is highly significant (P < 0.0002).

Results All studies showed a positive correlation between carotenoids and retinol, which was overall highly significant ( r = 0.50, P = 0.0002; Fig. 2 ; without apparent publication bias: rank test, P = 0.36 and funnel plot inspection).

For instance, the genus Clostridium exhibited the highest mean relative abundance in the high Ca treatment (V), with highly significant differences ( p = 0.0002) compared to the control (K) and most other treatments.

There was a highly significant difference of the mean internal carpal tunnel ratio between male patients and controls (male patients: 0.42 ± 0.05; male controls: 0.34 ± 0.04, P = 0.0002) as well as between female patients and controls (female patients: 0.39 ± 0.06; female controls: 0.35 ± 0.04, P = 0.034). 3.1.2.

This was a highly significant difference ( p = 0.0002).

Interestingly, our data revealed that a highly significant increase in myocilin expression (11.8-fold) was observed in TM region of the responder eyes compared to vehicle-treated eyes ( p = 0.0002); and there was a fourfold increase in myocilin expression in GC responder eyes ( p = 0.0004) compared with GC non-responder eyes.

Notably, the lowest tested concentration of HYAL (0.015 U/ml) demonstrated a highly significant induction of HAS2 expression compared to medium control (Fig. 2 b, p = 0.0002).

7 Here, at 13 months posttreatment, BST-CarGel treatment resulted in a highly significant improvement ( P = 0.0002) compared with MFx alone in the total macroscopic score, which encompasses the assessment of lesion fill, integration to native cartilage, and surface quality of the repair tissue.

There was highly significant difference on RI value at day 14 in dogs graded on day 1 of the trial as nonambulatory paraparetic versus paraplegic ( P = .0002), but treatment group remained not significant because of equal distribution of these grades between groups ( P = .73). 3.2.

This analysis revealed highly significant dependencies between FAA and the six EDA features (all p < 0.0002 ), indicating robust non-linear relationships.

With the exception of the consumer price index, all the nominally significant variables displayed in Text S1 (Table A) remained highly significant (P<0.0002 or lower) after Bonferroni correction for multiple testing.

Biological process annotations of these genes showed highly significant enrichment for lipid metabolism genes (P = 0.0002).

The effect of manufacturer on overall (global) taxonomic abundance was highly significant (p<0.0002).

Indeed there is a highly significant correlation between urinary glucose and the glucose tolerance test area under the curve (r=0.623, p=0.0002), a measure of insulin resistance not directly influenced by food intake.

There were pathogenic deletion variants in 5.26% of females and 3.69% of males, and this difference was highly significant (P < 0.0002) ( Fig. 2B ).