“highly significant”

Our results revealed highly significant synergistic genetic interactions between neb and polo for both symmetric cell divisions and earlier cell divisions ( P = 3.89 × 10 −4 and P = 1.00 × 10 −6 , respectively), but no significant interactions in the case of asymmetric cardiac progenitor cell divisions ( P = 0.117) (Figs. 5 a,d,e, 6 b, Supplementary Table S1 ).

In addition, similar and all highly significant ( p ≤ 3.9 × 10 −4 ) Pearson correlations were found between all three housekeeping genes; GAPDH, HBB, and ACTB, for all collection volumes ( Figure A3 ).

The DRD2 (Dopamine receptor D2)-variant (rs6277) was highly significant where the C-allele displayed a protective effect towards overweight development (OR: 0.79, 95% CI: 0.69–0.90, P = 3.9x10 -4 , adj.

Age had a highly significant association with reported keloid cases per million VMMCs performed, at p = 0.0004, with 1.09 vs 0.05 keloids reported for every million VMMCs performed among clients aged < 15 years and ≥ 15 years respectively.

Indeed, ABA3 expression kinetics obtained after infection by prtE and outC are not significantly or weakly significantly different from that obtained after buffer inoculation ( p -value = 0.0830 and 0.0411, respectively) in contrast to the highly significant differences between the WT strain ( p -value = 0.0004) or the hrcC mutant ( p -value = 0.0006) and the buffer ( Figure 3 and Supplementary Table S2 ).

Specifically, the partitioning around medoids (pam) clustering algorithm [ 29 ] with two centers predicted one cluster with 52 good outcome and 56 poor outcome patients, and another cluster with 56 good outcome and only 19 poor outcome events, which was highly significant under Fisher's exact test ( P = 0.0004; Figure 3c ).

These differences were statistically highly significant (Figure 4 A, t = -3.59, P = 0.0004; Figure 4 B, t = -2.59, P = 0.01; see “seedling survival”).

The conditional sums of squares of E a estimates revealed highly significant interspecific differences in the temperature dependency of both GP max ( F = 4.4; P -value = 0.0004) and NP max ( F = 8.4; P -value < 0.0001).

Indeed, Spearman’s correlation analysis of the OMAP index and pregnenolone production in U87MG cells treated with micromolar concentrations of the compounds revealed a highly significant p value ( p = 0.0004, Figure 3 ).

Kaplan-Meier analysis revealed a highly significant difference in MFS between the two classes ( P = 0.0004).

The fat contents of the studied plant revealed a highly significant variation ( p = 0.0004).

CfMYB2 (Figure 4E ): A significant main effect of both cultivar ( F = 10.04, p = 0.0012) and stage ( F = 5.21, p = 0.0164), as well as a highly significant cultivar × stage interaction ( F = 8.79, p = 0.0004), was observed for CfMYB2 expression.

These groups demonstrated highly significant improvements in OS (Bm2 hi /CCL3 lo HR = 0.14 (95%CI:0.04–0.49) p = 0.0004; Bm2 hi /CCL4 lo HR = 0.21 (95%CI:0.08–0.57), p = 0.001; and Bm2 hi /CXCL8 lo HR = 0.29 (95%CI:0.11–0.76), p = 0.007, Figure 5 ).

The differences of most within-litter variances between these two developmental stages were highly significant in all experimental groups (p<0.0004, Data S1 ).

Dogs receiving polytherapy have a highly significant increase in shaking, shivering, or trembling when left or are about to be left on their own when compared to dogs on monotherapy (question 22, P = 0.0004).

A highly significant difference was found in mean Vitamin D levels between cases and controls ( P = 0.0004).

Combining the results of the two populations, we observed a highly significant difference ( P =0.0004) of genotype and allele frequencies (odds ratio (OR)=1.46; 95% confidence interval (CI) 1.16–1.85; P =0.001) and of the homozygote ratio (OR=3.8; 95% CI 1.73–8.34; P =0.0001).

As shown in Figure 4 B, those patients with score 2 showed a highly significant poorer survival than those patients with score 0 or 1 in the Kaplan–Meier analysis ( p = 0.0004 and p = 0.0040, respectively).

In contrast, when we analyzed the striatum and the ventral forebrain of intraparenchymally grafted animals versus vehicle-injected controls, we observed highly significant 7-fold (p = 0.0004 ) and 35-fold (p = 0.0001 ) reductions in CD68 immunoreactivity, respectively.

Mirtazapine was also a highly significant suppressor of the histamine response when evaluating median wheal size for monotherapy compared to controls ( p = 0.0004) (Table 3 ).

The sexual difference was highly significant (P=0.0004, by one-way ANOVA).

The association was found to be statistically highly significant (p = 0.0004).

This level of overlapping is highly significant ( P = 4E-4, χ 2 test).

This enrichment was highly significant ( p = 0.0004) ( Table 1 ).

Also of note, 20 significant correlations were detected between selected outcomes including a moderate and highly significant correlation ( R = 0.59, p < 0.0004) between axial hypersensitivity and disc nerve sprouting.