“highly significant”

Although we did not look at the ratio of plasma tryptophan to other large neutral amino acids, the differences between total blood plasma tryptophan levels with (5–8 μmol/L) and without (51–182 μmol/L) ATD were highly significant ( p < 0.0005, Wilcoxon rank-sum test).

In addition, highly significant loci were detected on chromosome 8 of 320-02 at marker P14M37-134 ( P < 0.0005) and on chromosome 9 of 10618-01 at marker E32M48-233 ( P < 0.0001) (Table 2 ).

A highly significant relationship was found between Prm 2 promoter divergence and relative testes size ( r 2 =0.7065, p =0.0005)—independently or normalized in relation to Prm 1 promoter and to the neutral divergence assumed for INT ( figure 3 ; table 2 ).

Using Oneway ANOVA we found a very highly significant effect of treatment (disease) (p<0.0005), and post-hoc comparison of all parasitic diseases compared to the negative controls using Dunnet's test showed that none of these had a significantly greater IgG value than the controls except for fascioliasis using one-tailed test at 0.01% level.

All p -values are two-sided; p < 0.05 is considered significant, p < 0.005 highly significant, and p < 0.0005 very highly significant.

Changes of ESAS were highly significant, as well as the use of opioids and breakthrough pain medications (p <0.0005).

Non-parametric Kruskal–Wallis test shows a highly significant difference between the groups for all of the continuous outcome variables ( p <0.0005).

For this group, Bartlett’s test indicated the adequacy of the data to apply FA with a p -value highly significant ( p < 0.0005), leading to the rejection of the null hypothesis H0: The correlation matrix is equal to the identity matrix.

These differences across the genotypes (SI/SI and SC/SC) for number of days to germinate and percent germination were highly significant (Kruskal–Wallis, P ≤ 0.0005 for both).

An initial overall confounder-adjusted MANOVA test for expression in 13 immunity genes revealed a highly significant difference (main effect) between wild and mesocosm fishes ( F 14,256 = 3.72, P <0.0005).

Faroese smokers tended to have higher T than non-smokers (p=0.7, adjusted for BMI effect), whereas the effect on the Danish men were highly significant (p<0.0005).

The difference in level of relatedness between breeding pairs and random pairs was estimated at 0.07 and was highly significant (10,000 simulations, one-sided p -value = 0.0005).

All ICC values between CS and LG volumes were > 0.97 and were highly significant at p < 0.0005 ( Supplemental Table 2 ).

As shown, the msRT for the familiar face was ~60 ms longer than for each of the other faces, with a highly significant group average effect of 73 ms when comparing the familiar face to the average of all non-familiar faces (Fig. 3a , left panel, p = 0.0005 in a non-parametric permutation test, see Methods).

Differences in the LARS score among QoL categories were highly significant ( p < 0.0005) ( Figure 2 ).

Further ANCOVAs exploring the effects of group and hemisphere for each tract showed a highly significant effect of group for the UF, F(1,23) = 20.03, P<0.0005, and no corresponding effect for the IFOF, F(1,23) = 0.16, P>0.6.

However, a highly significant decrease of the transcript levels of the DA degradation enzyme COMT was observed in both A53T-SNCA overexpressing mouse lines ( Fig. 3 ; PrPmtA: −30%, n = 6, p = 0.0005 and PrPmtB: −26%, n = 7, p = 0.0018).

The results of this comparison, shown in Figure 3 , indicate a highly significant correlation (lesions per base: model = 0.9006 × [ΔΔ C t ] + 0.73; r = 0.89, P < 0.0005).

Tetramers with RNAmotifs Fisher’s p-values ≤ 0.05 (or the 1 st percentile of the p-value distribution in case of highly significant results) and empirical p-values ≤ 0.0005 were considered as enriched and retained for further analysis ( Table S5 ).

Serum MDA levels were found to be higher (6.846 ± 1.5) than controls (4.588 ± 1.17) while SOD levels were found to be lower in women with miscarriage (2.26 ± 0.66) than that of control group (3.16 ± 1.13) and difference were found to be highly significant ( P = 0.0005, <0.0001), respectively.

Poorer sleeping conditions also proved a highly significant predictor of poor net condition, i.e., having a pHI ≥ 175 had an odds ratio of 3.10 ( P < 0.0005).

In addition, the net reclassification improvement and integrated discrimination improvement were highly significant in all multimarker lipid panels alone and when added to the base model in the training set ( P ≤ 0.0005), an observation that was reproduced in the test set using the models that were developed in the training set.

However, the abandonment rates of den-captured bears were highly significant even when comparing with overall abandonment rates (χ 2 (1, N = 76) = 20.5, p<.0005) or when excluding those occasions where bears moved dens early in the season (χ 2 (1, N = 56) = 45.2, p<.0005).

The results revealed that the relative levels of EGFP protein expression in cells harbouring the pSSB vector were significantly lower than those in cells transfected with the pSB vector, with the difference being highly significant ( p < 0.0005).

The cortex comprised of 19 brain areas all showed a decrease in brain volume that was highly significant ( p = 0.0005) with a mean difference of −3.195.