“highly significant”

However, a highly significant decrease of the transcript levels of the DA degradation enzyme COMT was observed in both A53T-SNCA overexpressing mouse lines ( Fig. 3 ; PrPmtA: −30%, n = 6, p = 0.0005 and PrPmtB: −26%, n = 7, p = 0.0018).

There are 48 processes that are highly significant based on our data with FDR<0.005 and p < 0.0005 (FDR cut off value, stringently<0.05, normally<0.25), (see Additional file 3 for a complete list).

An initial overall confounder-adjusted MANOVA test for expression in 13 immunity genes revealed a highly significant difference (main effect) between wild and mesocosm fishes ( F 14,256 = 3.72, P <0.0005).

This is statistically highly significant (p < 0.0005) when comparing the group of hospitals with designated baby-friendly status in the past five years with those hospitals that had not been re-assessed for baby-friendliness in the past five years and with those that had never received baby-friendly status.

Student's `t`-test of 2 groups showed the remission period to be statistically highly significant in patients with stainless steel screw obturation, having P -value <0.0005.Obturating the foramen with stainless steel screws can prevent nerve regeneration.

Both the frontal and occipital petalia (see Table 2 ) were highly significant in humans [ t (90) = − 4.94, p < 0.0005 and t (90) = − 7.69, p < 0.0005, respectively], whereas no significant asymmetry was found in either petalia in chimpanzees.

This huge change is both practically important and highly significant statistically ( p < 0.0005 and Cohen's d for the change is 1.07, a large effect size).

The difference was highly significant for the lumbo-sacral segment ( p < 0.0005).

An NSF activity assay based on fluorescence dequenching (see “Methods”) shows a highly significant, ~72% reduction in the rate of SNARE complex disassembly ( p = 0.0005 ; Fig. 8D ).

These correlations, although weak (r– 0.17, r– 0.14 and r– 0.24, respectively), were highly significant (p = 0.0005, p = 0.005 and p<0.0001, respectively), ( Table 3 ).

A highly significant (p < 0.0005) decrease in pain threshold tolerance at the level of tenderness on skin rolling was found in comparison to non-tender control points in the thoracic spine [ 42 ].

A highly significant difference (p≤0.0005) in sialoadhesin mRNA levels was seen in AIDS patients (both AIDS-KS and non-AIDS-KS, median copy numbers per group ranged from 4.83×10 3 –2.35×10 4 /10 4 PBMC), and in HIV-1 infected a-symptomatic patients (median = 2.49×10 3 copies/10 4 PBMC) when compared with non-infected risk-group patients (median = 2.69×10 2 copies/10 4 PBMC) or with patients with exclusively an HHV-8 infection (median = 4.28×10 2 copies/10 4 PBMC).

The cortex comprised of 19 brain areas all showed a decrease in brain volume that was highly significant ( p = 0.0005) with a mean difference of −3.195.

Both the 300IR and 500IR groups had highly significant improvements in Rhinoconjunctivitis Total Symptom Score (RTSS) vs. placebo at the peak pollen season ( P =0.0005 and 0.0014, respectively), which agreed with improvements in RTSS in the primary evaluations.

WDSCC showed greater expression of E-Cadherin than MDSCC while PDSCC showed the least expression and the difference was highly significant ( P = 0.0005).

In addition, the net reclassification improvement and integrated discrimination improvement were highly significant in all multimarker lipid panels alone and when added to the base model in the training set ( P ≤ 0.0005), an observation that was reproduced in the test set using the models that were developed in the training set.

Regarding stage group, our study out of 36 resected cases revealed that combined MSH6 & PMS2 loss prevalent in stage III tumors (54.5%), followed by stage II tumors (45.5%), with a highly significant correlation combined markers loss between and III/II stages (p=0.0005).

A highly significant binomial GLMM (χ 2 ML = 33.24, N obs = 196, P < 0.0005; Table 1 ) revealed that, while controlling for the potentially confounding effects of age, sex, group size, the number of zoos a subject had lived in, and task identity, Sumatran subjects were significantly more likely to solve a task than their Bornean congeners (B = 1.934, SE = 0.74, z = 2.63, P < 0.01, Fig. 1 , Table 1 ).

However, the abandonment rates of den-captured bears were highly significant even when comparing with overall abandonment rates (χ 2 (1, N = 76) = 20.5, p<.0005) or when excluding those occasions where bears moved dens early in the season (χ 2 (1, N = 56) = 45.2, p<.0005).

The Wilcoxon signed ranks test value was negative and highly significant (z = -3.49, p < 0.0005.) Thus, HSAs with pediatric beds tend to have poorer Medicare-pediatric agreement than HSAs without pediatric beds.

In an analysis of variance (ANOVA) of absolute abundance of Faecalibacterium quantified by qPCR, with factors subject, presence/absence of tannins, allele at MEL6A, and all interactions between them, all factors were highly significant ( P -value <0.0005) except the interaction term for tannin and MEL6A allele ( Supplementary Table 8 ).

GSH was proven to enhance the sensitivities of the bare SPCEs towards Cd 2+ statistically at a highly significant level ( p = 0.0005). 33 Intriguingly, however, the sensitivities to Pb 2+ and Cu 2+ did not show any significant difference.

Compared to the baseline, a highly significant reduction of Fat Mass % (FM%) was observed (p-value=0.0005).

Similarly, highly significant correlations were observed for CD3+ T cells ( p = 0.0005), CD4+ T cells ( p = 0.0012) and CD68+ macrophages ( p = 0.0026) between the infiltration densities in the two different regions.

Histology and immunohistochemistry On HE stained sections (sagittal and coronal), treated and untreated cords differed dramatically: vacuolization due to tissue injury (cysts) was minimal in treated cords [ Figure 2 ; a1 and b1], with a highly significant difference with controls, a sign of the neuroprotective effects of PEG [ Figure 3a ; P = 0.0005].