“highly significant”

In Model 3 PCT + sCD14, a score of 2 is highly significant (p = 0.0006) and with increased odds (11.67 (2.82–57.08)) in the diagnosis of sepsis compared to a score of 1.

Analysis of the frequency trend with age (in centenarian and control groups combined) for polymorphisms in APOC3 and CETP ( Figure 1 ), revealed a highly significant ( p < 0.0006; β = 1.89 [95% CI, 0.2–3.6]) monotonically increasing frequency trend for homozygosity for the APOC3 −641 C allele (CC)(rs2542052), and near-significance (β = 3.06 [95% CI, 0.33–5.8, p = 0.069]) for homozygosity for the CETP codon 405 valine allele (VV)(rs5882).

5 b, right). Correlation analysis showed a highly significant positive correlation between the proportion of Oil Red O-positive adipocytes and the expression of CD271 in muscle-derived MSCs (Rho = 0.6304, p = 0.0006) (Fig. 5 c, left), whereas bone-derived MSC showed no such correlation (Rho = − 0.03668, p = 0.8649) (Fig. 5 c, right).

We showed a highly significant downregulation of nrf2 ( p = 0.0006, Figure 1A ) and nrf2 -induced genes mRNA levels in patients’ skin fibroblasts, HO-1 ( p = 0.001, Figure 1B ), GCL ( p < 0.0001, Figure 1C ), and TRX ( p < 0.0001, Figure 1D ) compared to healthy individuals.

The induction of CXCL8 and CXCL9 were highly significant in HSM ( p = <0.0001) as well as HSE ( p = 0.0006 and p = <0.0001, respectively) (Fig. 2a–b , Table 2 ), but the CSF-serum gradient was much more pronounced in HSM (factor of 40 and 12, respectively) compared to the HSE patient group (factor of 2.6 and 3.8, respectively) (Table 3 ).

However, the interaction with radiotherapy was highly significant ( p = 0.0006).

Given that these patients exhibited the most pronounced alterations in PCSK9 and sLDLR levels, the correlation of the PCSK9/sLDLR ratio with the presence of ≥ 5-cm metastases was also examined, revealing a highly significant correlation ( r = 0.4527, P = 0.0006), and difference of this ratio between patients without and with ≥ 5-cm metastases (3.21 ± 1.41 vs . 1.68 ± 0.62, P = 0.0006, Fig. 2 D).

Similarly, the Actin signaling pathway achieved a highly significant separation in females ( P = .0006) compared to a weaker association in males.

The pooled estimate remained highly significant (RR = 0.45 [0.29–0.71], p = 0.0006, I 2 = 0%).

However, nonparametric tests using Spearman correlations partially contradicted the significance of these results for Experiment nTP ( p = 0.14), while the effect in Experiment nSP remained highly significant ( p = 0.0006).

However, the ratio between CTX-I and TRAP5b, which is used as an index for resorption per osteoclast 33 , revealed a highly significant decrease in resorption per osteoclast ( P = 0.0006) (Fig. 7j ).

Additionally, these correlation coefficients are highly significant, having p -values < 6 × 10 − 4 .

This effect is statistically highly significant (γ = 95%, p = 0.0006).

Both differences were highly significant ( P = 0.0006 and P < 0.0001, Figure 1 A,B).

3.5 Aggregate statistics across simulations In our simulations, we calculated the SD of elbow angles ( Supplementary Table S5 ) and defined flexibility as SD > 10°, because at the 10° threshold the mutant showed a highly significant shift (two-sided Fisher’s exact test, P = 0.0006; Supplementary Table S6 ).

While Begg’s rank correlation test was borderline ( p = 0.0533), Egger’s linear regression test showed highly significant asymmetry ( p = 0.0006).

Signal correlation with soluble α-syn levels was less for 2D10 but comparable for 2D8 and highly significant for both sdAbs (2D10: r = 0.820, P = 0.0006; 2D8: r = 0.919, P < 0.0001).

A highly significant (P = 0.0006) and tight correlation (r = −0.9936) between increasing concentrations of sucrose and decreasing k cat values for DD-CoA was observed (Table ST2 ).

Following perfusion of the CB1R-specific inverse agonist LY320135 , there was a marked reduction in normalised gamma power to 39.4 ± 10.1% of control, and this was highly significant ( P ≤ .0006, n = 9).

The enrichment was highly significant and robust, and dependent on both the 33 genic and 38 intergenic insertion sites of the three species (1e-05< P <0.0006; Table 1 and Supplementary Data 3 ).

This rate difference was both congruent with the difference in ML estimates of ω [ 2 ] and highly significant ( P = 0.0006 by Student's unpaired t -test).

All success rates were highly significant above chance-level (33.3% on a 3-alternative-forced choice; p < 0.0006 (n = 7) for all comparisons, as assessed by a Wilcoxon rank sum test; importantly, this is the lowest p-value possible in this non-parametric test, given the number of subjects.

Molecular analyses showed highly significant down regulation of MUC1 expression in cells exposed to IL-1ß or TNF-α ( p = 0.0006; Fig. 5 ).

Combining these data with our previously published data revealed a highly significant association with MUTYH ( P =0.0006).

However, in the peritoneal cavity, a major anatomic residence of B-1 cells, neonatal SpA treatment resulted in a highly significant mean 78% reduction ( P = 0.0006) in the frequency of V H T15 transgene–expressing peritoneal B-1 cells (Mac-1 + B220 + ) (7.9 ± 1.1%, n = 7) compared with control treated mice (36.5 ± 3.2%, n = 6) ( Fig. 7 A).