“highly significant”

Figure 2 shows a highly significant ( p < 0.0006) monotonically increasing frequency trend for APOC-3 CC .

The enrichment was highly significant and robust, and dependent on both the 33 genic and 38 intergenic insertion sites of the three species (1e-05< P <0.0006; Table 1 and Supplementary Data 3 ).

Analysis of the frequency trend with age (in centenarian and control groups combined) for polymorphisms in APOC3 and CETP ( Figure 1 ), revealed a highly significant ( p < 0.0006; β = 1.89 [95% CI, 0.2–3.6]) monotonically increasing frequency trend for homozygosity for the APOC3 −641 C allele (CC)(rs2542052), and near-significance (β = 3.06 [95% CI, 0.33–5.8, p = 0.069]) for homozygosity for the CETP codon 405 valine allele (VV)(rs5882).

The observation of 6 cardio-metabolic disease genes out of 29 represents a highly significant enrichment (Fisher’s Exact Test p -value = 0.0006 [2-tailed], odds ratio = 29).

Molecular analyses showed highly significant down regulation of MUC1 expression in cells exposed to IL-1ß or TNF-α ( p = 0.0006; Fig. 5 ).

Similarly, the Actin signaling pathway achieved a highly significant separation in females ( P = .0006) compared to a weaker association in males.

Pulse rate and envelope type still had highly significant effects [ F (1, 7) = 34.02, P = 0.0006, η 2 = 0.10; and F (5, 35) = 4.8, P = 0.0029, η 2 = 0.23 respectively), as did ITD type [ F (1, 7) = 174.2, P < 10 −5 , η 2 = 0.13).

In the dominant model, carriers the C allele indicates protection to malaria, carriers of the C allele were compared to individuals with the T allele, and the difference is highly significant (OR 0.52 [95% CI 0.37–0.76]; p = 0.0006).

Our study was not designed to detect the correlation between HPDT and areas of secondary hyperalgesia; however, we find a highly significant result (P = 0.0006).

The meta-analysis was still highly significant and showed decreased clearance in the Aqp4 KO mouse lines (−1.92 [-3.02; −0.82]; p = 0.0006) with a lower degree of heterogeneity (I 2 = 64.1%, p = 0.0103).

During this period, we noted a highly significant decrease in the AAT risk in 2013 [ P = 0.0006, Table 1 ].

While variation in hK7 expression levels was highly significant in male patients suffering from asthma either since birth (p = 0.0006) or for the last 1-10 years.

Statistical analysis via one-way ANOVA confirmed a highly significant dose-response relationship (p = 0.0006), and a comparative analysis showed that the 4000 ug/disc concentration was statistically superior to the active control, caspofungin (5 ug/disc; 15.56 mm average, p = 0.0028).

Pre-pronation values of the PaO 2 /FiO 2 ratio were significantly different between groups (group S vs D: 150 ± 56 vs 115 ± 46; p = 0.006), but only pre-pronation FiO 2 remained highly significant at multivariate analysis (0.67 ± 0.16 vs 0.82 ± 0.18; univariate p = 0.0006, multivariate p = 0.001, OR 6.11).

A contingency χ 2 -test revealed highly significant ( p = 0.0006) statistical comparison of the exclusive variants in the patient population to those in the control group.

A comparison of the mEHT-treated and nontreated patients with the same stage brain tumors in the same research group in Italy [ 74 ] showed a highly significant ( p = 0.0006) response rate compared to the conventional control and also for GBM ( p = 0.026).

All success rates were highly significant above chance-level (33.3% on a 3-alternative-forced choice; p < 0.0006 (n = 7) for all comparisons, as assessed by a Wilcoxon rank sum test; importantly, this is the lowest p-value possible in this non-parametric test, given the number of subjects.

Statistical analysis of α-synuclein immunofluorescence in the striatum revealed a highly significant main effect of group (F (2,24) = 10.17, p = 0.0006), whereas neither sex (F (1,24) = 0.621, p = 0.438) nor the group × sex interaction (F (2,24) = 0.094, p = 0.911) showed significant effects.

After 24 h, an average of 930 NSDFs had migrated into the wound gap, compared to only 340 cells for SPDFs, corresponding to a highly significant difference of 2.7-fold ( p = 0.0006).

The first primary outcome variable tested, the difference between groups in TBUT, was in fact, highly significant (p=0.0006), and it is worth noting that the difference between groups for the second primary outcome, OSDI, did not approach statistical significance (p=0.9843).

Results are shown in Figure 2 , highlighting a mild but highly significant correlation with mast cells and erythroblasts ( R =0.25 and R =0.38, p-value = 0.0006 and 0.00000526, respectively), regardless of the hematological disease studied; on the contrary, no correlations were found with B- nor with T-cells.

The difference of resistance against starvation-induced cell death was highly significant with pIGFBP7 transfected Jurkat cells showing 85 % more proliferation measured by WST-1 signal on day four compared to the pCntrl cells ( P -value = 0.0006; Fig. 2b ).

The difference between type A and type D is particularly pronounced, with a highly significant difference of 5.47 ( p = 0.0006), showing that type D has a significantly higher opening distance than type A.

The difference in tumor incidence between MCPyV-Rb WT and MCPyV-Rb ΔL mice was highly significant (p = 0.0006; two-sided Fisher’s Exact Test).

While no such association was observed for older males, a highly significant sex-specific effect was observed when comparing female with male G -allele carriers ( P = 0.0006).