“highly significant”

For the presence-ratings from 1 to 100, the factor “Soundscape” was highly significant, F (1, 35) = 48.95, p < 0.001, with a large effect size (η 2 = 0.583), while the factor “Steps” had no significant effect, F (1, 35) = 0.003, p = 0.96, nor did their interaction, F (1, 35) = 0.531, p = 0.471.

Intraprocedural effects of cryo-PVI on heart rate When comparing heart rate at baseline versus one day after PVI a highly significant rate increase was observed (16.5 ± 1.6%; p < 0.001; n = 91 patients), which corresponded to an absolute acceleration of rate by 9.8 ± 0.9 beats/min.

Joint state was the most highly significant variable when analyzed independently, as well as with every other possible combination of variables included in the model ( P = 0.001).

Data were visualized using GraphPad Prism 7.0 statistical software, with p < 0.05 indicating a statistically significant difference, p < 0.01 indicating a highly significant difference, and p < 0.001 indicating an extremely significant difference.

Similar to our findings with the previous tests, three-way ANOVA showed a highly significant sex dimorphism in favor of female mice (trial: F (8, 171) = 4.617, p < 0.001, sex: F (1, 171) = 24.02, p < 0.001; trial × sex: F (8, 171) = 2.656, p < 0.01; sex X treatment group; F (1, 171) = 4.039, p < 0.05).

A chi-square test confirmed a highly significant association between comorbidities and complication types ( p < 0.001) ( Table 7 ).

In a random population sample comprising more than 2,000 individuals, a highly significant ( P <0.001) association was observed between hypertension and glucose intolerance, independent of the potentially confounding effects of age, sex, obesity, and anti-hypertensive medications.

The koalas’ GI microbiomes both immediately prior to a phase and after a phase were equally highly significant predictors of messmate intake (B:F ratio, before: t = − 4.055, p < 0.001, after: t = − 4.090, p < 0.001; PC1 scores, before: t = − 3.890, p < 0.001, after: t = − 3.884, p < 0.001; delta AIC: B:F ratio = 0.201, PC1 scores= 0.068), while the koala’s GI microbiomes at capture were not (PC1 scores: t = − 0.522, p = 0.618).

On multivariate analysis, previous stroke/transient ischaemic attack/thromboembolism was a predictor of higher risk of stroke, death and the composite of ‘stroke and death’, while VKA treatment was a highly significant predictor of a lower risk for death (adjusted HR 0.46, 95% CI 0.28 to 0.74, p<0.001) and the combined end point of death or stroke (adjusted HR 0.64, 95% CI 0.43 to 0.96, p=0.003).

The correlation between the severity scores generated by the azanitriles against the parasite and their potency of inhibition of SmCB1 was highly significant ( Table S3 , Spearman correlation test with nonzero value coefficients, 20 000 permutations, p < 0.001).

Statistical analysis revealed a highly significant effect of light phase (χ 2 = 56.81, p < 0.001), whereas no significant main effect of treatment was detected (χ 2 = 0.68, p = 0.71), nor was a significant treatment × light interaction observed (χ 2 = 10.25, p = 0.115).

When samples were subdivided into the proposed four groups, F ST values were low but highly significant (p<0.001) and ranging from 0.0015 in the comparison between WMED and AEG to 0.0070 in the comparison between the ION and ATL clusters.

The terms clustered semantically along the X -axis based on the similarity: highly significant terms ( p < 0.001) including “actin cytoskeleton organization” and “fiber polymerization,” clustered on the left, progressed to “response to mechanical stimuli” and terminated on the right with signaling pathways, including G-protein coupled receptors (GPCR), regulation of interleukin-8 (CXCL8) production, and Rho protein signal transduction (Fig. 4e , Supplementary Fig. 3b ).

24 In our study, a statistically highly significant and positive correlation was found between PI and saliva HGF which suggests that an increase in PI leads to an increase in saliva HGF (ρ = +0.390, p < 0.001).

On intergroup comparison, it was statistically highly significant ( P <0.001).

euphratica seedlings showed highly significant positive correlations with vascular bundle structure and midrib thickness (r = 0.63~0.91, p < 0.001), while soluble sugar content exhibited a highly significant negative correlation with vascular bundle structure (r = −0.74~−0.80, p < 0.001).

At an initial 1 μM concentration, the pure CR showed 94.6% cell viability, whereas the CR-MC depicted highly significant ( p < 0.001) cell viability (60.86%).

Teeth wise in cortical bone significant values were found at premolar region ( P = 0.046) and in cancellous bone significant values were found at canine and premolar region ( P = 0.012) and highly significant values were found at molar region ( P = 0.001).

We demonstrated a highly significant decrease of the RLA between fragments with 9, 17, and 24 units compared with the wild-type allele comprising 2 units ( P < 0.001) with a maximum decrease of 52% in the 24 units containing promoter ( Fig. 3 ).

One study showed that the use of the Hepcon device resulted in a highly significant reduction in the total protamine dose compared to ACT-based dosing (mean protamine dose: 14.190 IU vs 24.777 IU; P < 0.001) and total blood loss (mean blood loss: 804 ml vs 1416 ml; P < 0.001) [ 495 ].

One study showed that the use of the Hepcon device resulted in a highly significant reduction in the total protamine dose compared to ACT-based dosing (mean protamine dose: 14.190 IU vs 24.777 IU; P < 0.001) and total blood loss (mean blood loss: 804 ml vs 1416 ml; P < 0.001) [ 495 ].

Cox Proportional Hazard interaction analysis revealed a highly significant statistical interaction for OS between CC score and chemotherapy response, CCscore*chemo response p < 0.001.

Significance was defined as P < 0.05 and “highly significant” as P < 0.001 ( Altman, 1991 ).

Copy number alterations of 52, 35, and 35 genes also showed highly significant correlations ( P < .001) with ER negativity (positive in 14 tumors vs negative in 6 tumors), PgR‐negativity (positive in 11 tumors vs negative in 9 tumors), and higher Ki‐67 labeling indexes (less than 20% in 12 tumors vs 20% or higher in 8 tumors), respectively.

Improvement noticed in QDNOS score was found to be statistically highly significant ( p < 0.001).