“indeterminate significance”

Furthermore, some authors have indicated that chemotherapy is of indeterminate significance in patients with PCNSL [ 7 ].

In addition, there are several mildly FDG avid mediastinal, left hilar, and upper abdominal nodes seen, which are of indeterminate significance.

USE is unlikely to be useful in terms of altering the clinical decision of whether to perform FNAC for nodules that are already very suspicious for malignancy or completely benign on conventional US. Another potential role for USE is for nodules with non-diagnostic or indeterminate cytological results on FNAC (e.g., cellular atypia of indeterminate significance), which affects approximately 30% of FNACs [ 61 – 63 ].

A computerised tomography (CT) scan of the thorax, abdomen and pelvis was performed demonstrating a cluster of sub-centimetre lymph nodes in the right paracolic gutter of indeterminate significance.

Within the measurement error of mSASSS, that scores of 1 is intermediate, and perhaps of indeterminate significance.

In our patient, a cardiac sarcoma occurred 20 years after she underwent a bilateral mastectomy and two cycles of 50 Gy radiation therapies for each breast, and it should be listed as a potential contributor, yet with indeterminate significance because of the current level of statistical evidence in the particular matter of primary intimal sarcomas at heart.

Imaging also revealed bilateral pulmonary nodules of indeterminate significance that were felt to be unrelated to the migration.

In the abnormal squamous cell category the distribution of lesions was as follows: Atypical squamous cells of indeterminate significance (ASC-US) were 7.1%; atypical squamous cells, cannot exclude high squamous intraepithelial lesion (ASC-H) were 1.08%; low grade squamous intraepithelial lesion (LSIL) including human papillomavirus was 2.2%, high grade squamous intraepithelial lesion (HSIL) was 0.8% and high grade squamous intraepithelial lesion with suspicious invasion was 0.06% smears.

Posttreatment tumour contrast retention often seen on CT immediately post procedure is of indeterminate significance.

In a second case suffering from PPHCD [ 3 ], a standardized SPARK Inherited Retinal Dystrophy (IRD) panel was performed testing several mutations of indeterminate significance across multiple genes, including CCD2D2A, CEP78, NR2E3, PCARE, PEX14, and RPGRIP1.

The significance of these restrictions can be understood by considering clinically-impactful categories of lymph node metastases, including those that are greater than 0.2 cm (significant), micrometastases between 0.02 to 0.2 cm (indeterminate significance), and isolated tumor cells less than 0.02 cm (low significance) 1 , 3 .

Clonal hematopoiesis of indeterminate significance (CHIP) refers to somatic mutations that occur within hematopoietic stem cells and is associated with increased cardiovascular risk, including myocardial infarction, and decreased overall survival. 83 , 84 Interestingly, an increased prevalence of CHIP has been noted in patients who have received pr

Altogether we scored the variant as of Indeterminate significance [ 4 ].

A potential pathogenic connection with the prior viral infection may be suspected, yet of indeterminate significance at this point [ 42 , 43 ].

Lucencies between 1 and 2 mm are generally considered to have indeterminate significance while lucencies < 1 mm are unlikely to be of clinical significance[ 13 ].

(0 and 1 were collapsed since 1 represents signal hyperintensity on T2-weighted images of indeterminate significance.) Subchondral sclerosis was scored at baseline from 0 to 3 for each region of the knee as: 0: none, 1: <25% of the subregion, 2: 25–50% of the subregion, 3: >50% of the subregion.

Atypical cells of indeterminate significance were divided according to their place of origin: glandular or squamous, AGG or ASC, respectively.

Our predictive model based on conventional US features and BRAF V600E shows that combining capsule contact, C-TIRADS, and BRAF V600E mutations can assist in distinguishing the benignity and malignancy of thyroid nodules with indeterminate significance.

This scan was negative for PE but did demonstrate a small focus of peripheral non-specific ground glass opacification in the right lower lobe of indeterminate significance.

Ageing and cancer are both associated with the accumulation of mutations in DNA [ 66 ], and, among other changes, ageing affects the hematopoietic clonal heterogeneity (designated either as ARCH for age‐related clonal haematopoiesis or as CHIP for clonal haematopoiesis of indeterminate significance).

Livers of treated animals showed fibrin around the capsule and extramedullary hematopoiesis (EMH) of indeterminate significance.

However, FNAC is characterized by a grey diagnostic area (Thy3) due to the finding, in about 10% of the specimens, of cellular atypia of indeterminate significance which precludes a distinction between benign and malignant lesions [20] .

A total of 50% of the patients had no indication of colposcopy, that is, normal cytologies, benign changes, ectopia, cervicitis, atypical squamous cells of indeterminate significance (ASC-US) and low-grade intraepithelial lesion (LSIL) without persistence and normal clinical appearance.

Overall, 10-15% of FNAs provide inadequate results, while a diagnosis of follicular/oxyphilic lesions of indeterminate significance is made in 10-20% of FNAs 5 .

Chest X-ray showed mild bronchial wall thickening in the right lower zone with a few ill-defined small opacites of indeterminate significance.