Barely Significant
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markedly significant

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In the literature

This is consistent with BfmR’s characteristics as a transcription factor capable of activating or inhibiting the transcription of diverse genes. Setting Siph-1 as a reference inhibitor for its reported BfmR inhibitory activity and binding pose, we noticed that the conformational dynamics of BfmR were less significant when combined with agonists or modulators, but markedly significant when combined with inhibitors ( Figure 7 ).
Our observation that the adverse joint effect of NAFLD and sarcopenia on mortality remained markedly significant even after adjustment for other metabolic comorbidities and advanced fibrosis emphasizes the need to perform stratified analysis by risk factors when seeking to predict long‐term prognoses in subjects with metabolic derangements.
Moreover, the observed markedly significant reduction in the ratio of Bax/Bcl2 elevated levels in the cells exposed to a DOX challenge and co-treated with Brb-loaded cationic mixed micelle indicates the pivotal role of mitochondrial selectivity in enhancing the mitohormetic effects of Brb to mediate cardiovascular cellular resilience. 4.