Barely Significant
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may be significant

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In the literature

With respect to the effects on long-term plasticity, since LTP reaches normal levels at the later phase, we predict that some tests in Hirano body mice will indicate normal capacity for learning and memory, although deficits related to the impairment of the early phase of LTP may be significant.
In contrast, sargramostim, a recombinant human GM-CSF is under investigation, to improve the immune response by recruiting neutrophils, dendritic cells and macrophages to fight the virus and to repair tissue damage ( Table 1 ), although there may be significant risks including neurotoxicity ( 103 ).
Neutrophils in COVID-19: Not Innocent Bystanders.
Front Immunol · 2022 · PMC9199383
1 Consequences of DDIs may be significant, like increase in toxicity of interacting drugs or morbidity and mortality rate; however, they are predictable and preventable adverse drug events. 2 , 3 Screening patients’ medications to detect DDIs can minimize the harmful consequences of the interactions. 4 Critically ill patients are at an inc
2 Four years later the same group reported the primary structures of PFL and PFL-AE, and noted “a cluster of three cysteines...which may be significant for the putative Fe-binding and redox-functional properties of this enzyme.” 61 This cysteine “cluster” was, of course, the canonical radical SAM superfamily CX 3 CX 2 C motif.
Radical S-adenosylmethionine enzymes.
Chem Rev · 2014 · PMC4002137