Barely Significant
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may be significant

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In the literature

The high GC content may be significant because of two reasons ‐ firstly the higher GC ratio gives a higher chance of complementarities with the coding regions also having a higher GC ratio, secondly since GC pair is bound by 3 hydrogen bonds, these bonds are more stable, so the miRNA binding and degradation of the target genes may be more probable.
Positive hits based on a single read may be significant and should be investigated, depending on the coverage level and other criteria. • Could NGS be used in combination with a previous step of cell culture for enrichment? o Blandine de Saint-Vis indicated that it could be done but it would require a cell sensitive to all viruses and monoclonal antibodies to neutralize the virus from the vaccine, so this is a challenge.
(These restarts did not seem to have an impact in the experiments we performed but may be significant in settings with larger step sizes or other datasets.) Therefore, one has to define a candidate space, a scoring function to evaluate a candidate solution, a neighborhood of a candidate solution, as well as a decision rule for selecting the next candidate out of a neighborhood.