“modest significance”

In our approach, it is based on being unable to reject H 0 at modest significance levels.

A follow-up study in another independent sample of schizophrenia cases and controls from the Ashkenazi Jewish population replicated the women-specific association with schizophrenia of rs7341475, although with very modest significance [27] .

It is possible that the modest significance derived on linear regression with severity is a reflection of such a phenomenon.

On the basis of candidate gene studies or modest significance levels in previous GWASs, researchers have proposed associations for many genes with PD to date.

Since FCRL3 nsSNPs demonstrated modest significance and was later confirmed as a GD susceptibility locus, other borderline signals in this study have since been investigated.

We discovered several other directional effects of modest significance ( Table 2 ), including lagged health on closeness (0.45, 0.09–0.81) and lagged prosocial behavior on closeness (0.46, 0.02–0.91).

The relatively modest significance of T3SS to pathogenicity in pectobacteria is also reflected in the small number of T3 effectors found in these species compared, for example, to the dozens of known effectors of Pseudomonas syringae [60] .

The FAX-1 LBD was most similar to the NR2F2 COUP LBD, albeit with modest significance.

dorsalis within core- Notamacropus rejected only at modest significance levels (P values from 0.079–0.334).

The CLEC16A gene showed modest significance in all approaches, except for the Fp method ( Table 4 ).

The sequence of the spacer appears to be less critical, although it has a modest significance (B mutation in Fig. 4 A,B).

The modest significance value reflects the small overall effect on AO in the HD population, and this is due to the low frequency of the deletion (0.25%) and duplication alleles (1.9%).

The nine DHSs reaching modest significance in the ileum were not near any gene known to be regulated by microbiota (Supplemental Table S7; Rawls et al. 2006 ; Donohoe et al. 2011 ; El Aidy et al. 2012 ; Larsson et al. 2012 ; Pott et al. 2012 ).

Although our analyses identified several AML-related TFs such as PU1, C-Fos, YY1, some of the other AML-related TF regulators such as p300 and C-Myc [48] exhibit either no or rather modest significance (e.g., -statistic 7.58; p-value 0.0059; FDR 0.15 for C-Myc) based on our analysis, which may indicate an over-stringent cutoff (FDR 0.1) used in the feature selection procedure or the intrinsic difference between the mRNA expression and the cognate TF activities.

32 – 33 The variables nominally associated with the MAPK14 variants within the dyslipidemia subgroup need to be interpreted with caution due to the modest significance levels and small number of carriers, but are provided for descriptive purposes.

The modest significance level might be due to the low number of matching groups.

By contrast, 3’SS in general did not appear to play a major role in intronic C/P in the samples analyzed in this study, except for some modest significance for the last introns containing upregulated pAs by siSF3b155 and siU2AF65 ( Fig 3D ).

In addition, the identified pathway and genes showed modest significance when multiple testing is considered, and only one SNP in antigen processing and presentation pathway was significant in NCI samples with moderate p value.

Given the modest significance of our findings, further research is needed to confirm these suggestive associations.

More modest significance levels were seen at 13q32 (rs7982677) in intron 7 of GPC5 and the non-synonymous substitution Ile733Val in NRP1 [ 33 ].

Given the sample size, the relatively modest significance levels are surprising, but may result from the large variance seen both within and across age and diagnostic groups ( Figure 2 ).

Our results suggest also that independent genetic markers need not necessarily be separate genetic variants; those can also be synthetic variables composed from epistatically interacting individual markers that alone do not reach even the modest significance level.

Tumors with loss of the other miRNAs showed a modest significance for this region (hsa-mir-137; Fig. 6 B ) or no significance (hsa-mir-23b; data not shown).

1 ), but the strongest interaction involving this SNP was of modest significance (rs609203 × rs4848623; follow-up interaction p -value: 0.0026; data not shown).

While the current study supports previous suggestions of increased mortality risk and hemolysis parameters with prolonged QTc, it is important to note our findings of association of QTc with mortality are of modest significance and do not imply a causal mechanism for death.