“near-significant”

Metadata categories that returned a significant or near-significant result in adonis tests were further investigated using PERMANOVA [ 42 ] and permdisp tests [ 44 ].

When we instead conducted models with potency-weighted sums of bioactive PBDEs based on Tox21 data (which excluded BDE-209), we found significant or near-significant associations with interference of TR β and ER α .

Nonetheless, all these conditions were associated with a statistically significant, or near-significant, reduction in progression-free survival (PFS) compared to the control (unaltered) group (Fig. 5 B).

The near-significant p -value for 3-pts score could warrant further investigation with larger samples or more statistical power. 5.

While statistically significant and near-significant results were reported, the study did not calculate effect sizes.

Notably, nicotine had near-significant interactions with the association between VPBs and both J and S amplitudes (Table 1 ), suggesting nicotine may modify the relationship between VPBs and early repolarization.

Multivariable regression was applied to variables that demonstrated significant or near-significant differences in the univariate analysis.

The closest estimate being comorbid depression at baseline which was found to have a near-significant association with ASRS change, such that depressed participants showed less improvement in self-reported ADHD symptoms over the course of treatment.

No statistically significant differences were found among the subgroups, though there was a near-significant difference in age.

Binary logistic regression analysis was then performed with the significant and near-significant items to adjust for confounding factors.

That is, for non-viewpoint markers, Egocentric Intrusion had a numerically positive, near-significant effect on rereading rate, and this effect was significantly more positive for cognitive viewpoint markers.

The marginal p -value of 0.062 suggests a near-significant upward trend with cumulative usage.

As described in Methods, we were motivated to distinguish migraine-related from non-migraine-related symptoms where potentially relevant to significant or near-significant group differences.

While our study showed a near-significant effectiveness of posterior wall ablation in PersAF patients, this finding is at best hypothesis generating: this near-significant finding was achieved in patients undergoing repeat (not initial) ablation, with difference in subgroups in terms of baseline characteristics, lesion set during initial ablation, and ablation energy used during repeat ablation.

The near-significant effect in heterozygotes may reflect a partial additive influence on thoracic development.

Compared to the alkylating agent alone, we observed significant, or near-significant increases in growth delays for all three alkylating agents when combined with LND.

[ 73 ] on patients affected by diffuse axonal injury (a subset of TBI seen with blunt trauma to the head) [ 186 ] reported a near-significant positive trend in cognitive outcomes in the group randomised to three 360 mg capsules of boswellic acids per day compared to placebo, for whom spontaneous recovery during the study period did not approach statistical significance.

Results indicate that each peak was specific for one trait without overlapping near-significant effects for other traits, possibly implying the absence of interactions between QTL detected.

However, from the regression results on the occupation factor, retirement status demonstrates a near-significant correlation with subway travel.

A large MR study with CHD as its primary endpoint also reported a near-significant effect of a functional variant causing impaired signalling at the IL-6 receptor on lower T2DM risk [ 26 ].

This showed that there was a significant association between these fragile sites and the FANCD2 regions and a near-significant association between these fragile sites and the enriched PEB-BLOC regions.

In addition, the near-significant result in the second cohort warrants further investigation, because it may still hold biological relevance.

For example, the significantly increased proportion of bioirrigators in the Long treatment (and the near-significant increase in the Short treatment) could be discussed in the context of the elevated CO2 and CH4 influxes reported in Douglas et al.

Focal players with a higher skill achieved relative to the experimental player also made more positive comments (β = 0.29, χ 2 = 5.12, p = 0.02); there was a near-significant interaction with manipulation such that the experimental player in the female-voiced treatment received more positive comments when focal players were of a higher skill level, but fewer positive comments when the experimental player was higher in skill ( Fig 2 ).

Nevertheless, we demonstrate that OSM, TGF-β1, and Snail drive a significant change to the Epithelial-Mesenchymal Transition Hallmark gene signature from the Molecular Signatures database, with Zeb1 driving a near-significant alteration (Supplementary Fig. 7 A–D).